The Depression GWAS Risk Allele Predicts Smaller Cerebellar Gray Matter Volume and Reduced SIRT1 mRNA Expression in Chinese Population

2019 ◽  
Author(s):  
Weipeng Liu ◽  
Hao Yan ◽  
Danyang Zhou ◽  
Xin Cai ◽  
Yuyanan Zhang ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Gray Matter ◽  
Chinese Population ◽  
Risk Allele ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Cerebellar Gray Matter

scholarly journals The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Weipeng Liu ◽  
Hao Yan ◽  
Danyang Zhou ◽  
Xin Cai ◽  
Yuyanan Zhang ◽  
...  
Keyword(s):  
Gray Matter ◽  
Genome Wide Association Study ◽  
Risk Allele ◽  
Gray Matter Volume ◽  
Postmortem Brain ◽  
Mrna Levels ◽  
Chinese Sample ◽  
Matter Volume ◽  
Genome Wide ◽  
Cerebellar Gray Matter

AbstractMajor depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivotal roles in MDD pathogenesis, the genetic and phenotypic heterogeneity of the illness has hampered the discovery of its genetic determinants. In this study, in an independent Han Chinese sample (1824 MDD cases and 3031 controls), we conducted replication analyses of two genetic loci highlighted in a previous Chinese MDD genome-wide association study (GWAS), and confirmed the significant association of a single nucleotide polymorphism (SNP) rs12415800 near SIRT1. Subsequently, using hypothesis-free whole-brain analysis in two independent Han Chinese imaging samples, we found that individuals carrying the MDD risk allele of rs12415800 exhibited aberrant gray matter volume in the left posterior cerebellar lobe compared with those carrying the non-risk allele. Besides, in independent Han Chinese postmortem brain and peripheral blood samples, the MDD risk allele of rs12415800 predicted lower SIRT1 mRNA levels, which was consistent with the reduced expression of this gene in MDD patients compared with healthy subjects. These results provide further evidence for the involvement of SIRT1 in MDD, and suggest that this gene might participate in the illness via affecting the development of cerebellum, a brain region that is potentially underestimated in previous MDD studies.

123. Cerebellar gray matter volume deficits in schizophrenia and alcoholism

2000 ◽  
Vol 47 (8) ◽  
pp. S37
Author(s):  
E.V. Sullivan ◽  
A. Deshmukh ◽  
J.E. Desmond ◽  
D.H. Mathalon ◽  
M.J. Rosenbloom ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Cerebellar Gray Matter

P 3 Cerebellar gray matter volume decrease is associated with epileptic seizures in multiple sclerosis

2017 ◽  
Vol 128 (10) ◽  
pp. e327
Author(s):  
M. Grothe ◽  
M. Süße ◽  
F. von Podewils ◽  
S. Langner ◽  
M. Lotze ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Epileptic Seizures ◽  
Matter Volume ◽  
Cerebellar Gray Matter ◽  
Volume Decrease

scholarly journals Increased cerebellar gray matter volume in head chefs

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171457 ◽  
Author(s):  
Antonio Cerasa ◽  
Alessia Sarica ◽  
Iolanda Martino ◽  
Carmelo Fabbricatore ◽  
Francesco Tomaiuolo ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Cerebellar Gray Matter

The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population

2016 ◽  
Vol 171 (3) ◽  
pp. 396-401 ◽  
Author(s):  
Liang Huang ◽  
Yin Mo ◽  
Xuejin Sun ◽  
Hualin Yu ◽  
Hao Li ◽  
...  
Keyword(s):  
Gray Matter ◽  
Chinese Population ◽  
Allelic Variation ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
The Impact

Effects of the CACNA1C Risk Allele for Bipolar Disorder on Cerebral Gray Matter Volume in Healthy Individuals

2009 ◽  
Vol 166 (12) ◽  
pp. 1413-1414 ◽  
Author(s):  
MATTHEW J KEMPTON ◽  
GAIA RUBERTO ◽  
EVANGELOS VASSOS ◽  
ROBERTO TATARELLI ◽  
PAOLO GIRARDI ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Risk Allele ◽  
Gray Matter Volume ◽  
Healthy Individuals ◽  
Matter Volume

scholarly journals Maternal cerebellar gray matter volume is associated with daughters’ psychotic experience

2020 ◽  
Vol 74 (7) ◽  
pp. 392-397
Author(s):  
Naoki Hashimoto ◽  
Timothy I. Michaels ◽  
Roeland Hancock ◽  
Ichiro Kusumi ◽  
Fumiko Hoeft
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Psychotic Experience ◽  
Matter Volume ◽  
Cerebellar Gray Matter

scholarly journals ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia

NeuroImage ◽  
2011 ◽  
Vol 54 (3) ◽  
pp. 2132-2137 ◽  
Author(s):  
Gary Donohoe ◽  
Emma Rose ◽  
Thomas Frodl ◽  
Derek Morris ◽  
Ilaria Spoletini ◽  
...  
Keyword(s):  
Gray Matter ◽  
Risk Allele ◽  
Gray Matter Volume ◽  
Matter Volume

scholarly journals Cerebellar Gray Matter Volume, Executive Function, and Insomnia: Gender Differences in Adolescents

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kyu-In Jung ◽  
Min-Hyeon Park ◽  
Bumhee Park ◽  
Shin-Young Kim ◽  
Yae On Kim ◽  
...  
Keyword(s):  
Gender Differences ◽  
Executive Function ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Cerebellar Gray Matter
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