The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

2019 ◽  
Author(s):  
Xingting Guo ◽  
Chang Yin ◽  
Fu Yang ◽  
Yongchao Zhang ◽  
Huanwei Huang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Enteroendocrine Cells ◽  
Factor Code

scholarly journals The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

Cell Reports ◽  
2019 ◽  
Vol 29 (12) ◽  
pp. 4172-4185.e5 ◽  
Author(s):  
Xingting Guo ◽  
Chang Yin ◽  
Fu Yang ◽  
Yongchao Zhang ◽  
Huanwei Huang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Enteroendocrine Cells ◽  
Factor Code

scholarly journals The transcription factor code in iPSC reprogramming

2021 ◽  
Vol 70 ◽  
pp. 89-96
Author(s):  
Weixian Deng ◽  
Elsie C Jacobson ◽  
Amanda J Collier ◽  
Kathrin Plath
Keyword(s):  
Transcription Factor ◽  
Factor Code

scholarly journals Specification of Neuropeptide Cell Identity by the Integration of Retrograde BMP Signaling and a Combinatorial Transcription Factor Code

Cell ◽  
2003 ◽  
Vol 113 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Douglas W. Allan ◽  
Susan E.St. Pierre ◽  
Irene Miguel-Aliaga ◽  
Stefan Thor
Keyword(s):  
Transcription Factor ◽  
Bmp Signaling ◽  
Cell Identity ◽  
Factor Code

scholarly journals Expression of Hey marks a subset of enteroendocrine cells in the Drosophila embryonic and larval midgut

2021 ◽  
Author(s):  
Emilia Skafida ◽  
Christos Delidakis ◽  
Maria Monastirioti
Keyword(s):  
Nervous System ◽  
Transcription Factor ◽  
Notch Signaling ◽  
Asymmetric Division ◽  
Enteroendocrine Cells ◽  
Larval Midgut ◽  
Mammalian Genomes ◽  
Low Levels ◽  
Newborn Neurons ◽  
Mother Cells

Hey is a conserved transcription factor of the bHLH-Orange family and it participates in the response to Notch signaling in certain tissues. Whereas three Hey paralogues exist in mammalian genomes, Drosophila possesses a single Hey gene. Fly Hey is expressed in the subset of newborn neurons that receive a Notch signal to differentiate them from their sibling cells after the asymmetric division of precursors called ganglion-mother-cells. We used a polyclonal anti-Hey serum and a GFP-tagged transgenic duplication of the Hey locus to examine its expression in tissues outside the nervous system in embryos and larvae. We detected robust Hey expression in the embryonic midgut primordium at the time of birth of enteroendocrine cells, identified by expression of Prospero. About half of the Pros-positive cells were also Hey positive at mid-embryogenesis. By the end of embryogenesis, most enteroendocrine cells had downregulated Hey expression, although it was still detectable at low levels after hatching. Low levels of Hey were also detected in subsets of the epithelial enterocytes at different times. Embryo enteroendocrine Hey expression was found to be Notch dependent. In late third-instar larvae, when few new enteroendocrine cells are born, novel Hey expression was detected in one cell of each sibling pair. In conclusion, Hey is strongly expressed in one of each pair of newly-born enteroendocrine cells. This is consistent with a hypothesis that embryonic enteroendocrine cells are born by an asymmetric division of a precursor, where Notch/Hey probably distinguish between the subtypes of these cells upon their differentiation.

scholarly journals Crosstalk between C/EBPβ phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code

2010 ◽  
Vol 29 (6) ◽  
pp. 1105-1115 ◽  
Author(s):  
Elisabeth Kowenz-Leutz ◽  
Ole Pless ◽  
Gunnar Dittmar ◽  
Maria Knoblich ◽  
Achim Leutz
Keyword(s):  
Transcription Factor ◽  
Arginine Methylation ◽  
Factor Code
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