Exosomes from Mesenchymal Stromal Cells Reduce Murine Colonic Inflammation via a Macrophage-Dependent Mechanism

2019 ◽  
Author(s):  
Huashan Liu ◽  
Zhenxing Liang ◽  
Fengwei Wang ◽  
Chi Zhou ◽  
Xiaobin Zheng ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Colonic Inflammation ◽  
Dependent Mechanism

scholarly journals Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism

JCI Insight ◽  
2019 ◽  
Vol 4 (24) ◽  
Author(s):  
Huashan Liu ◽  
Zhenxing Liang ◽  
Fengwei Wang ◽  
Chi Zhou ◽  
Xiaobin Zheng ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Colonic Inflammation ◽  
Dependent Mechanism

scholarly journals P064 Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S166-S166
Author(s):  
X R Wu ◽  
P Lan ◽  
X J Wu ◽  
X Gao
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Inflammatory Responses ◽  
Intestinal Barrier ◽  
Experimental Colitis ◽  
Protective Effects ◽  
Trinitrobenzenesulfonic Acid ◽  
Macrophage Depletion ◽  
Inflammatory Bowel ◽  
Dependent Mechanism

Abstract Background Conventional treatments for inflammatory bowel disease (IBD) have multiple potential side effects. Therefore, alternative treatments are desperately needed. Exosomes from mesenchymal stromal cells (MSC-Exos) show potent immunomodulatory activities and protective effects in several diseases. Methods MSC-Exos were isolated from human bone marrow-derived mesenchymal stromal cells. Experimental colitis was induced by administration of dextran sulphate sodium (DSS) in C57BL/6 mice (male, 6–8 weeks), or 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) in Balb/c mice (male, 7–9 weeks). Macrophage depletion was performed via intraperitoneal injection of clodronate liposomes. Colitic mice were treated intravenously with MSC-Exos or saline, and mortality and diverse disease signs were tracked. Results Systemic administration of MSC-Exos significantly mitigated colitis in mice. MSC-Exos treatment downregulated inflammatory responses, maintained intestinal barrier integrity and polarised M2 macrophages. Infused MSC-Exos mainly acted on colonic macrophages and their beneficial effect was blocked by macrophage depletion. Particularly, MSC-Exos were enriched in proteins involved in regulating multiple biological processes associated with the anti-colitic benefit of MSC-Exos. Conclusion MSC-Exos are critical regulators of immune/inflammatory responses and may be promising candidates for IBD treatment

scholarly journals The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism

Stem Cells ◽  
2016 ◽  
Vol 34 (12) ◽  
pp. 2916-2929 ◽  
Author(s):  
Joseph B. Moore ◽  
John Zhao ◽  
Matthew C. L. Keith ◽  
Alok R. Amraotkar ◽  
Marcin Wysoczynski ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Epigenetic Regulator ◽  
Dependent Mechanism
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