Upregulation of Long Noncoding RNA Meg3 Induced by DNA Hypomethylation Maintains Stemness and Pluripotency of Mouse Embryonic Stem Cells in Folate Supplementation via Stabilization of LYAR

2019 ◽  
Author(s):  
Hui Miao ◽  
Yin-Ling Zhang ◽  
Cheng-Yang Liu ◽  
Shu-Han Luo ◽  
Jing-Cheng Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Dna Hypomethylation ◽  
Folate Supplementation

scholarly journals Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells

2007 ◽  
Vol 12 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Kohta Ikegami ◽  
Misa Iwatani ◽  
Masako Suzuki ◽  
Makoto Tachibana ◽  
Yoichi Shinkai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Deficient Mouse ◽  
Dna Hypomethylation ◽  
Genome Wide

scholarly journals Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells

2013 ◽  
Vol 110 (8) ◽  
pp. 2876-2881 ◽  
Author(s):  
A. A. Sigova ◽  
A. C. Mullen ◽  
B. Molinie ◽  
S. Gupta ◽  
D. A. Orlando ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Gene Pairs ◽  
Mrna Gene ◽  
Divergent Transcription

scholarly journals The long noncoding RNA lncR492 inhibits neural differentiation of murine embryonic stem cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191682 ◽  
Author(s):  
Maria Winzi ◽  
Nuria Casas Vila ◽  
Maciej Paszkowski-Rogacz ◽  
Li Ding ◽  
Svenja Noack ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Noncoding Rna ◽  
Neural Differentiation ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells

scholarly journals Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Marie MacLennan ◽  
Marta García-Cañadas ◽  
Judith Reichmann ◽  
Elena Khazina ◽  
Gabriele Wagner ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Translational Regulation ◽  
Genome Stability ◽  
De Novo ◽  
Genetic Disorders ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Dna Hypomethylation ◽  
Genomic Locations

Mobilization of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders. In humans, retrotransposon mobilization is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilize in pluripotent cells early in development. Here we show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the L1-encoded protein L1-ORF1p, stimulate its polyubiquitylation and degradation, and restrict L1 mobilization. We also show that TEX19.1 likely acts, at least in part, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p. Moreover, loss of Tex19.1 increases L1-ORF1p levels and L1 mobilization in pluripotent mouse embryonic stem cells, implying that Tex19.1 prevents de novo retrotransposition in the pluripotent phase of the germline cycle. These data show that post-translational regulation of L1 retrotransposons plays a key role in maintaining trans-generational genome stability in mammals.

scholarly journals Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells

2017 ◽  
Vol 9 (1) ◽  
pp. 108-121 ◽  
Author(s):  
Keriayn N. Smith ◽  
Joshua Starmer ◽  
Sarah C. Miller ◽  
Praveen Sethupathy ◽  
Terry Magnuson
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Self Renewal

scholarly journals Tex19.1 Restricts LINE-1 Mobilisation in Mouse Embryonic Stem Cells

2017 ◽  
Author(s):  
Marie MacLennan ◽  
Marta García-Cañadas ◽  
Judith Reichmann ◽  
Elena Khazina ◽  
Carmen Salvador-Palomeque ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Ubiquitin Ligase ◽  
Translational Regulation ◽  
Genome Stability ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Dna Hypomethylation ◽  
Pluripotent Cells ◽  
Genomic Locations

AbstractMobilisation of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution. In humans, retrotransposon mobilisation is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilise in pluripotent cells early in development. Here we show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the L1-encoded protein L1-ORF1p, stimulate its polyubiquitylation and degradation, and restrict L1 mobilisation. We also show that TEX19.1 likely acts, at least in part, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p. Moreover, we show that loss of Tex19.1 increases L1-ORF1p levels and mobilisation of L1 reporters in pluripotent mouse embryonic stem cells implying that Tex19.1 prevents new retrotransposition-mediated mutations from arising in the germline genome. These data show that post-translational regulation of L1 retrotransposons plays a key role in maintaining trans-generational genome stability in the epigenetically dynamic developing mammalian germline.

scholarly journals DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

Cell Reports ◽  
2016 ◽  
Vol 17 (2) ◽  
pp. 353-365 ◽  
Author(s):  
Kaveh Daneshvar ◽  
Joshua V. Pondick ◽  
Byeong-Moo Kim ◽  
Chan Zhou ◽  
Samuel R. York ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Definitive Endoderm ◽  
Endoderm Differentiation

scholarly journals A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Ya-Pu Li ◽  
Fei-Fei Duan ◽  
Yu-Ting Zhao ◽  
Kai-Li Gu ◽  
Le-Qi Liao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Erk Signaling
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