PGAM1 Modulates Paclitaxel-Resistance in Ovarian Cancer Cells Through Controlling Pyruvic Acid Production in Glycolysis

2019 ◽  
Author(s):  
Yan Feng ◽  
Xu Zhang ◽  
Songfa Zhang ◽  
Shanshan Xu ◽  
Xiaojing Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Pyruvic Acid ◽  
Acid Production ◽  
Ovarian Cancer Cells ◽  
Paclitaxel Resistance

scholarly journals Mitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells

2019 ◽  
Vol Volume 12 ◽  
pp. 3881-3891 ◽  
Author(s):  
Weina Guo ◽  
Weihong Dong ◽  
Min Li ◽  
Yi Shen
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Paclitaxel Resistance ◽  
P Glycoprotein

Abstract 3436: MiR-194 modulates paclitaxel resistance in ovarian cancer cells through the regulation of MDM-2 expression

2017 ◽  
Author(s):  
Koji Nakamura ◽  
Kenjiro Sawada ◽  
Akihiko Yoshimura ◽  
Erica Nakatsuka ◽  
Yasuto Kinose ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Paclitaxel Resistance

scholarly journals CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2

2021 ◽  
Vol 11 ◽  
Author(s):  
Yaqing Zhang ◽  
Hongyun Gan ◽  
Fei Zhao ◽  
Xiaomei Ma ◽  
Xiaofeng Xie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Rna Binding ◽  
Ovarian Cancer Cells ◽  
Drug Resistant ◽  
Paclitaxel Resistance ◽  
Cytoplasmic Polyadenylation

Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important role. The cytoplasmic polyadenylation element binding protein 4 (CPEB4) is an RNA binding protein that controls mRNA cytoplasmic polyadenylation and translation.Methods: The expression of CPEB4 in paclitaxel-resistant ovarian cancer cell lines and recurrent ovarian tumors relative to counterparts was determined by qRT-PCR, Western blotting and immunohistochemistry. The response to paclitaxel treatment was evaluated by cellular viability test and colony formation assay. RNA immunoprecipitation and poly(A) tail test were applied to examine the levels of RNA binding and cytoplasmic polyadenylation.Results: CPEB4 is elevated in paclitaxel-resistant ovarian cancer cells and recurrent ovarian tumors treated with paclitaxel-based chemotherapy. In addition, CPEB4 overexpression promotes paclitaxel resistance in ovarian cancer cells in vitro, and vice versa, CPEB4 knockdown restores paclitaxel sensitivity, indicating that CPEB4 confers paclitaxel resistance in ovarian cancer cells. Mechanistically, CPEB4 binds with the taxol (paclitaxel)-resistance-associated gene-3 (TRAG-3/CSAG2) mRNAs and induces its expression at a translational level. Moreover, CSAG2 expression is upregulated in paclitaxel-resistant ovarian carcinoma and cancer cell lines, and more importantly, siRNA-mediated CSAG2 knockdown overtly attenuates CPEB4-mediated paclitaxel resistance.Conclusion: This study suggests that the drug-resistant protein CSAG2 is translationally induced by CPEB4, which underlies CPEB4-promoted paclitaxel resistance in ovarian cancer in vitro. Thus, interfering CPEB4/CSAG2 axis might be of benefit to overcome paclitaxel-resistant ovarian cancer.

scholarly journals CRM197 reverses paclitaxel resistance by inhibiting the NAC‐1/Gadd45 pathway in paclitaxel‐resistant ovarian cancer cells

2019 ◽  
Vol 8 (14) ◽  
pp. 6426-6436
Author(s):  
Xiao‐han Tang ◽  
Hui Li ◽  
Xiu‐shuang Zheng ◽  
Mei‐song Lu ◽  
Yuan An ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Paclitaxel Resistance

scholarly journals Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells

2016 ◽  
Vol 67 ◽  
pp. 152-163 ◽  
Author(s):  
Kuan-Chun Huang ◽  
Junzheng Yang ◽  
Michelle C. Ng ◽  
Shu-Kay Ng ◽  
William R. Welch ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Paclitaxel Resistance ◽  
Cyclin A1

scholarly journals Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Chi Lam Au Yeung ◽  
Ngai-Na Co ◽  
Tetsushi Tsuruga ◽  
Tsz-Lun Yeung ◽  
Suet-Ying Kwan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Paclitaxel Resistance
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