Long-Term Exposure to Elevated Lipoprotein(A) Levels Influences Human Longevity

2019 ◽  
Author(s):  
Benoit Arsenault ◽  
William Pelletier ◽  
Yannick Kaiser ◽  
Nicolas Perrot ◽  
Christian Couture ◽  
...  
Keyword(s):  
Human Longevity ◽  
Lipoprotein A

scholarly journals Long-Term Exposure to Elevated Lipoprotein(a) Levels, Parental Lifespan and Risk of Mortality

2019 ◽  
Author(s):  
Benoit J. Arsenault ◽  
William Pelletier ◽  
Yannick Kaiser ◽  
Nicolas Perrot ◽  
Christian Couture ◽  
...  
Keyword(s):  
Cardiovascular Mortality ◽  
Event Rate ◽  
Human Longevity ◽  
Uk Biobank ◽  
Lipoprotein A ◽  
The Uk ◽  
Genetically Determined ◽  
The Impact ◽  
Age Of Death

ABSTRACTBackgroundElevated Lipoprotein(a) (Lp[a]) levels are associated with a broad range of atherosclerotic cardiovascular diseases (CVD). The impact of high Lp(a) levels on human longevity is however controversial. Our objectives were to determine whether genetically-determined Lp(a) levels are associated with parental lifespan and to assess the association between measured and genetically-determined Lp(a) levels and long-term all-cause and cardiovascular mortality.MethodsWe determined the association between a genetic risk score of 26 single nucleotide polymorphisms weighted for their impact on Lp(a) levels (wGRS) and parental lifespan (at least one long-lived parent; father still alive and older than 90 or father’s age of death ≥90 or mother still alive and older than 93 or mother’s age of death ≥93) in 139,362 participants from the UK Biobank. A total of 17,686 participants were considered as having high parental lifespan. We also investigated the association between Lp(a) levels and all-cause and cardiovascular mortality in 18,720 participants from the EPIC-Norfolk study.ResultsIn the UK Biobank, increases in the wGRS (weighted for a 50 mg/dL increase in Lp(a) levels) were inversely associated with a high parental lifespan (odds ratio=0.92, 95% confidence interval [CI]=0.89-0.94, p=2.7×10−8). During the 20-year follow-up of the EPIC-Norfolk study, 5686 participants died (2412 from CVD-related causes). Compared to participants with Lp(a) levels <50 mg/dL, those with Lp(a) levels ≥50 mg/dL had an increased hazard ratio (HR) for all-cause (HR=1.17, 95% CI=1.08-1.27) and cardiovascular (HR=1.54, 95% CI=1.37-1.72) mortality. Compared to individuals with Lp(a) levels below the 50th percentile of the Lp(a) distribution (in whom event rates were 29.8% and 11.3%, respectively for all-cause and cardiovascular mortality), those with Lp(a) levels equal or above the 95th percentile of the population distribution (≥70 mg/dL) had HRs of 1.22 (95% CI=1.09-1.37, event rate 37.5%) and 1.71 (95% CI=1.46-2.00, event rate 20.0%), for all-cause mortality and cardiovascular mortality, respectively.ConclusionsResults of this study suggest a potentially causal effect of Lp(a) on human longevity, support the use of parental lifespan as a tool to study the genetic determinants of human longevity, and provide a rationale for a trial of Lp(a)-lowering therapy in individuals with high Lp(a) levels.

Long-term effects of niceritrol on serum lipoprotein(a) and lipids in patients with high levels of lipoprotein(a)

1995 ◽  
Vol 17 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Kazunobu Yamauchi ◽  
Yoshifumi Tanahashi ◽  
Mitsuhiro Okada ◽  
Jitsuki Tsuzuki ◽  
Akihiko Sato ◽  
...  
Keyword(s):  
Serum Lipoprotein ◽  
Long Term Effects ◽  
Lipoprotein A

Long-term treatment effect of lipoprotein apheresis in patients with isolated lipoprotein(a) elevation

2020 ◽  
Vol 315 ◽  
pp. e145
Author(s):  
F. Schumann ◽  
L. Haberbosch ◽  
A. Rosada ◽  
E. Steinhagen-Thiessen ◽  
U. Kassner
Keyword(s):  
Treatment Effect ◽  
Term Treatment ◽  
Lipoprotein A ◽  
Lipoprotein Apheresis ◽  
Long Term Treatment

scholarly journals FOXO Transcriptional Factors and Long-Term Living

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ghulam Murtaza ◽  
Abida Kalsoom Khan ◽  
Rehana Rashid ◽  
Saiqa Muneer ◽  
Syed Muhammad Farid Hasan ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Healthy Aging ◽  
Growth Stress ◽  
Human Longevity ◽  
Growth Factor Signaling ◽  
Forkhead Box ◽  
Foxo Transcription Factors ◽  
Genetic And Environmental Factors

Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.

scholarly journals Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy

2010 ◽  
Vol 51 (10) ◽  
pp. 3055-3061 ◽  
Author(s):  
Stephen J. Nicholls ◽  
W. H. Wilson Tang ◽  
Heather Scoffone ◽  
Danielle M. Brennan ◽  
Jaana Hartiala ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Statin Therapy ◽  
Lipoprotein A
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