Type 2 Diabetes Complications and Comorbidity in Sub-Saharan Africans

2019 ◽  
Author(s):  
Kenneth Ekoru ◽  
Ayo Doumatey ◽  
Amy R. Bentley ◽  
Guanjie Chen ◽  
Jie Zhou ◽  
...  
2019 ◽  
Author(s):  
Kenneth Ekoru ◽  
Ayo Doumatey ◽  
Amy R. Bentley ◽  
Guanjie Chen ◽  
Jie Zhou ◽  
...  

2019 ◽  
Vol 16 ◽  
pp. 30-41 ◽  
Author(s):  
Kenneth Ekoru ◽  
Ayo Doumatey ◽  
Amy R. Bentley ◽  
Guanjie Chen ◽  
Jie Zhou ◽  
...  

2017 ◽  
Vol 11 ◽  
pp. S1047-S1051 ◽  
Author(s):  
Heitham Awadalla ◽  
Sufian K. Noor ◽  
Wadie M. Elmadhoun ◽  
Ahmed O. Almobarak ◽  
Nehad E. Elmak ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Youssra Dakroury ◽  
Stephen L. Atkin ◽  
Soha R. Dargham ◽  
Amal Robay ◽  
Juan Rodriguez-Flores ◽  
...  

Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry. Conclusion. These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2223-PUB
Author(s):  
STEPHEN ATKIN ◽  
ALEXANDRA E. BUTLER

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 689
Author(s):  
Chika Horikawa ◽  
Rei Aida ◽  
Shiro Tanaka ◽  
Chiemi Kamada ◽  
Sachiko Tanaka ◽  
...  

This study investigates the associations between sodium intake and diabetes complications in a nationwide cohort of elderly Japanese patients with type 2 diabetes aged 65–85. Data from 912 individuals regarding their dietary intake at baseline is analyzed and assessed by the Food Frequency Questionnaire based on food groups. Primary outcomes are times to diabetic retinopathy, overt nephropathy, cardiovascular disease (CVD), and all-cause mortality during six years. We find that mean sodium intake in quartiles ranges from 2.5 g to 5.9 g/day. After adjustment for confounders, no significant associations are observed between sodium intake quartiles and incidence of diabetes complications and mortality, except for a significant trend for an increased risk of diabetic retinopathy (p = 0.039). Among patients whose vegetable intake was less than the average of 268.7 g, hazard ratios (HRs) for diabetic retinopathy in patients in the second, third, and fourth quartiles of sodium intake compared with the first quartile were 0.87 (95% CI, 0.31–2.41), 2.61 (1.00–6.83), and 3.70 (1.37–10.02), respectively. Findings indicate that high sodium intake under conditions of low vegetable intake is associated with an elevated incidence of diabetic retinopathy in elderly patients with type 2 diabetes.


BMC Medicine ◽  
2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Charles Agyemang ◽  
Karlijn Meeks ◽  
Erik Beune ◽  
Ellis Owusu-Dabo ◽  
Frank P. Mockenhaupt ◽  
...  

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