Role of GPRC6A in Regulating Hepatic Energy Metabolism

2019 ◽  
Author(s):  
Min Pi ◽  
Fuyi Xu ◽  
Ruisong Ye ◽  
Satoru K. Nishimoto ◽  
Robert A. Kesterson ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Hepatic Energy Metabolism

scholarly journals Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Min Pi ◽  
Fuyi Xu ◽  
Ruisong Ye ◽  
Satoru K. Nishimoto ◽  
Robert W. Williams ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Hepatic Energy Metabolism

scholarly journals Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

2000 ◽  
Vol 20 (17) ◽  
pp. 6508-6517 ◽  
Author(s):  
Pengxiang She ◽  
Masakazu Shiota ◽  
Kathy D. Shelton ◽  
Roger Chalkley ◽  
Catherine Postic ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Intermediary Metabolites ◽  
Hepatic Energy Metabolism ◽  
Genes Encoding ◽  
Plasma Hormone ◽  
Hepatic Genes ◽  
Targeting Strategy ◽  
Global Reduction

ABSTRACT We used an allelogenic Cre/loxP gene targeting strategy in mice to determine the role of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) in hepatic energy metabolism. Mice that lack this enzyme die within 3 days of birth, while mice with at least a 90% global reduction of PEPCK, or a liver-specific knockout of PEPCK, are viable. Surprisingly, in both cases these animals remain euglycemic after a 24-h fast. However, mice without hepatic PEPCK develop hepatic steatosis after fasting despite up-regulation of a variety of genes encoding free fatty acid-oxidizing enzymes. Also, marked alterations in the expression of hepatic genes involved in energy metabolism occur in the absence of any changes in plasma hormone concentrations. Given that a ninefold elevation of the hepatic malate concentration occurs in the liver-specific PEPCK knockout mice, we suggest that one or more intermediary metabolites may directly regulate expression of the affected genes. Thus, hepatic PEPCK may function more as an integrator of hepatic energy metabolism than as a determinant of gluconeogenesis.

scholarly journals Mechanism of ATGL mediated changes in hepatic energy metabolism: role of LFABP

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Kuok Teong Ong ◽  
Mara T. Mashek ◽  
Nicholas O. Davidson ◽  
Douglas G. Mashek
Keyword(s):  
Energy Metabolism ◽  
Hepatic Energy Metabolism

Effect of Methylprednisolone and Reduced Glutathione on Survival in Mice and Hepatic Energy Metabolism in Rats with Endotoxin Shock

1985 ◽  
Vol 1 (3) ◽  
pp. 249-251
Author(s):  
I. Kosugi ◽  
K. Tajimi ◽  
K. Okada
Keyword(s):  
Energy Metabolism ◽  
Sodium Succinate ◽  
Endotoxin Shock ◽  
Free Radical Scavenger ◽  
The Body ◽  
Radical Scavenger ◽  
Beneficial Effects ◽  
Methylprednisolone Sodium Succinate ◽  
Hepatic Energy Metabolism

Reduced glytathione (GSH) is the tripeptide of glycine, cysteine and glutamic acid and is widely distributed in the body. FSH has been reported to comprise at least 90% of the nonprotein sulfhydryl (NPSH). Although the role of GSH in the tissue has not been clearly established, it is known to be a cofactor for enzymes, a substrate in detoxifications, and a free radical scavenger.Several investigators have reported that the level of NPSH, mainly GSH, in the tissue was decreased in several types of shock and that exogenous administration of GSH has beneficial effects on shock (1,2). This study was designed to evaluate the effects of GSH on the survival rate in mice and the hepatic energy metabolism in rats after administration of endotoxin. These results were compared with those of methylprednisolone sodium succinate (MP), since many investigators have reported that the large doses of glucocorticoid have beneficial effects in several types of shock in experimental animals and in man (3,4).

scholarly journals Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish

2020 ◽  
Vol 21 (4) ◽  
pp. 1533
Author(s):  
Suzan Attia Mawed ◽  
Yan He ◽  
Jin Zhang ◽  
Jie Mei
Keyword(s):  
Energy Metabolism ◽  
Fish Species ◽  
Cellular Proliferation ◽  
Hepatocyte Proliferation ◽  
Nutrient Metabolism ◽  
Metabolic Defects ◽  
Hepatic Energy Metabolism ◽  
Hepatic Glucose ◽  
Inflammatory Phenotypes

Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. Accordingly, mutant zebrafish lines of autophagy-related genes beclin1 and atg7 were generated by CRISPR/Cas9 gene-editing technology. Interestingly, unlike atg7+/−, male beclin1+/− zebrafish displayed liver defects in the morphology and histology, including abnormal hepatocyte proliferation, hemorrhagic and inflammatory phenotypes. A significant decrease in hepatocyte glycogen and an increase in hepatocyte lipids were detected in the histological assay that coincidence with the hepatic gene expression. Meanwhile, loss of heterozygosity for beclin1 creates a suitable microenvironment for hepatic tumorigenesis via phosphorylation of Akt kinase, which in turn affects liver autophagy. The reduction in autophagy activity in male beclin1+/− liver leads to a disturbance in the glucose/lipid metabolism and negatively regulates apoptosis accompanied by the induction of cellular proliferation and acute inflammatory response. Our findings highlight an important role of beclin1 in zebrafish liver development and energy metabolism, suggesting the crucial role of autophagy in maintaining homeostasis of the nutrient metabolism in fish species.

The role of lipophagy in hepatic energy metabolism

2017 ◽  
Vol 263 ◽  
pp. e13-e14
Author(s):  
Christina Leopold ◽  
Douglas Mashek ◽  
Dagmar Kratky
Keyword(s):  
Energy Metabolism ◽  
Hepatic Energy Metabolism

Mitochondrial matrix calcium ions regulate energy production in myocardium: A cytochemical study

1990 ◽  
Vol 48 (2) ◽  
pp. 166-167
Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet
Keyword(s):  
Energy Metabolism ◽  
Calcium Ions ◽  
Energy Production ◽  
Regulation Of Respiration ◽  
Free Calcium ◽  
Mitochondrial Matrix ◽  
Cytochemical Study ◽  
Nmr Techniques

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.

scholarly journals Role of Natural Antioxidants on Neuroprotection and Neuroinflammation

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 608
Author(s):  
Domenico Nuzzo
Keyword(s):  
Reactive Oxygen Species ◽  
Energy Metabolism ◽  
Respiratory Chain ◽  
Reactive Oxygen ◽  
Natural Antioxidants ◽  
Oxygen Species

All cells continuously generate reactive oxygen species (ROS) through the respiratory chain during the energy metabolism process [...]

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