FOX-A1 Contributes to Acquisition of Chemoresistance in Human Lung Adenocarcinoma via Transactivation of SOX5

2019 ◽  
Author(s):  
Dongqin Chen ◽  
Rui Wang ◽  
Chen Yu ◽  
Fei Cao ◽  
Xuefeng Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Lung Adenocarcinoma

scholarly journals Antimigratory Effects of the Methanol Extract fromMomordica charantiaon Human Lung Adenocarcinoma CL1 Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Hsue-Yin Hsu ◽  
Jung-Hsuan Lin ◽  
Chia-Jung Li ◽  
Shih-Fang Tsang ◽  
Chun-Hao Tsai ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Human Lung ◽  
Human Cancer ◽  
Momordica Charantia ◽  
Invasive Ability ◽  
Human Cancer Cells ◽  
Human Lung Adenocarcinoma ◽  
Significant Difference

Momordica charantiahas been found to exhibit anticancer activity, in addition to its well-known therapeutic functions. We have demonstrated that the leaf extract ofMomordica charantia(MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells. MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt,β-catenin, and MMPs.

Direct activation of procaspase-3 inhibits human lung adenocarcinoma in a murine model

2010 ◽  
Vol 211 (3) ◽  
pp. S36 ◽  
Author(s):  
Syed Shahzad Razi ◽  
Gary Schwartz ◽  
Xiaogui Li ◽  
Deva Boone ◽  
Scott Belsley ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Murine Model ◽  
Human Lung ◽  
Human Lung Adenocarcinoma ◽  
Direct Activation
Sign in / Sign up

Export Citation Format

Share Document