Active Factor Completion Strategies

2019 ◽  
Author(s):  
Hubert Dichtl ◽  
Wolfgang Drobetz ◽  
Harald Lohre ◽  
Carsten Rother
Keyword(s):  
Active Factor

Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives

2004 ◽  
Vol 12 (20) ◽  
pp. 5415-5426 ◽  
Author(s):  
Hiroyuki Koshio ◽  
Fukushi Hirayama ◽  
Tsukasa Ishihara ◽  
Hiroyuki Kaizawa ◽  
Takeshi Shigenaga ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitor ◽  
Active Factor ◽  
Orally Active

The Imaginal Ecdysis of Blowflies. The Control of Cuticuar Hardening and Darkening

1962 ◽  
Vol 39 (3) ◽  
pp. 395-412
Author(s):  
C. B. COTTRELL
Keyword(s):  
Blood Transfusion ◽  
Critical Period ◽  
Body Wall ◽  
The Body ◽  
Internal Organs ◽  
Active Factor

1. Blood transfusion experiments show that normal hardening and darkening at the imaginal ecdysis of CaUiphora erythrocephala (Meigen) is brought about by the release into the blood of an active factor. Introduction of this factor into a newly emerged fly some 35 min. prior to the time at which it would normally be released is sufficient to prevent expansion. 2. The factor is normally released some 45 min. before the appearance of the first signs of darkening and between 3 and 15 min. after the fly has reached conditions suitable for expansion, that is at about the time of initiation of air-pumping. 3. Decapitation at emergence will prevent the initiation of normal hardening and darkening but not of secondary darkening. Evidently the head is concerned in the release or the control of the release of the blood-borne darkening factor. 4. The critical period for the prevention of normal hardening and darkening by decapitation lies between 3 and 15 min. after the fly has reached conditions suitable for expansion. 5. Isolated abdomina behave in a manner similar to decapitated flies but their reactions are complicated by secondary darkening associated with damage. 6. Flies deprived of their abdomina will expand at least partially but the rate of their hardening and darkening is reduced. 7. Damage reactions resembling secondary darkening in digging flies are more extensive after damage to internal organs such as the gut than to superficial organs such as the body wall. 8. Allowing for the effects of secondary darkening it is possible to demonstrate the occurrence of the blood-borne darkening factor by means of ligatures placed at emergence between the thorax and the abdomen. Under these conditions only the head and thorax exhibit normal darkening.

scholarly journals Isolation of a carbohydrate-rich immunologically active factor from cultures ofLeishmania tropica

FEBS Letters ◽  
1977 ◽  
Vol 80 (2) ◽  
pp. 401-404 ◽  
Author(s):  
Gerald M. Slutzky ◽  
Charles L. Greenblatt
Keyword(s):  
Active Factor

Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors

2008 ◽  
Vol 16 (5) ◽  
pp. 2243-2260 ◽  
Author(s):  
Yasuhiro Imaeda ◽  
Toshio Miyawaki ◽  
Hiroki Sakamoto ◽  
Fumio Itoh ◽  
Noriko Konishi ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Active Factor ◽  
New Class ◽  
Orally Active

scholarly journals THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE

1915 ◽  
Vol 22 (6) ◽  
pp. 675-681 ◽  
Author(s):  
J. Harold Austin ◽  
O. H. Perry Pepper
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
General Circulation ◽  
Portal System ◽  
Bile Pigment ◽  
Portal Circulation ◽  
Active Factor ◽  
Mechanical Influence ◽  
Number Of Cells

These experiments indicate, therefore, that when hemoglobin is set free in the portal circulation a larger amount is held by the liver and converted rapidly into bile pigment than is the case when it is set free in the general circulation, and that, under the former condition, over-loading of the liver with bile pigment more readily occurs and jaundice is more apt to develop. This mechanical influence must, therefore, be a factor in the lessened tendency after splenctomy to the jaundice which follows blood destruction due to hemolytic agents, for whether the spleen be an active factor in destroying the erythrocytes or whether it plays merely a passive part as a place for the deposition of the disintegrating cells, there can be no question that in this organ, when it is present, a large number of cells undergo their final disintegration after the action of hemolytic poisons, and that the hemoglobin there liberated passes by the portal system directly to the liver. When the spleen is removed, this disintegration occurs in other organs, notably in the lymph nodes and bone marrow, and the hemoglobin from these organs passes not into the portal but into the general circulation, from which it reaches the liver more gradually and in a more dilute form.

Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors

2008 ◽  
Vol 16 (6) ◽  
pp. 3125-3140 ◽  
Author(s):  
Yasuhiro Imaeda ◽  
Tetsuji Kawamoto ◽  
Mamoru Tobisu ◽  
Noriko Konishi ◽  
Katsuhiko Hiroe ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Active Factor ◽  
Orally Active
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