Hydrogen Gas Inhalation Alleviates Radiation-Induced Bone Marrow Damage in Cancer Patients

2019 ◽  
Author(s):  
Shin-ichi Hirano ◽  
Yukimasa Aoki ◽  
Ryosuke Kurokawa ◽  
Xiao-Kang Li ◽  
Naotsugu Ichimaru ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cancer Patients ◽  
Hydrogen Gas ◽  
Bone Marrow Damage ◽  
Radiation Induced ◽  
Gas Inhalation ◽  
Hydrogen Gas Inhalation

scholarly journals Protective effect of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study

2020 ◽  
Author(s):  
Shin-ichi Hirano ◽  
Yukimasa Aoki ◽  
Ryosuke Kurokawa ◽  
Xiao-Kang Li ◽  
Naotsugu Ichimaru ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Observational Study ◽  
Cancer Patients ◽  
Blood Cells ◽  
Inhalation Therapy ◽  
Control Group ◽  
Gas Treatment ◽  
Bone Marrow Damage ◽  
Radiation Induced ◽  
Gas Inhalation

Abstract Background: Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, but reducing bone marrow damage is limited in the patients with multiple tumor lesions and large irradiation volume. Thus, novel technology is needed to mitigate further IMRT-induced bone marrow damage. Molecular hydrogen (H2) was recently reported as a preventive and therapeutic antioxidant that selectively scavenges hydroxyl radical (·OH) and peroxynitrite (ONOO-). This observational study aims to examine whether H2 gas treatment improves IMRT-induced bone marrow damage in cancer patients. Methods: The patients with end stage of cancer were received IMRT once per day for 1 to 4 weeks except Saturday and Sunday. After each course of IMRT, the patients of control group (n = 7) were housed in health care chamber (HCC, mild hyperbaric oxygen chamber) for 30 minutes, and the patients of H2 group (n = 16) were also housed in HCC and received 5% H2 gas for 30 minutes once per day. Radiation-induced bone marrow damage was evaluated by hematological examination of peripheral blood obtained before and after IMRT, and the data was expressed the ratio of after treatment to before treatment.Results: The total number of radiation courses and total exposure doses of radiation were similar between the control and H2 groups. IMRT with HCC therapy significantly reduced white blood cells (WBC) and platelets (PLT), but not red blood cells (RBC), hemoglobin (HGB) and hematocrit (HT). In contrast, H2 gas treatment significantly alleviates reducing effects of WBC and PLT (p=0.0011 and p=0.0275, respectively). Bone marrow damage index calculated by total exposure dose and WBC ratio also demonstrated the radioprotective effects of H2 gas (p=0.0231). Tumor responses to IMRT were similar between the two groups, and 4 of 7 (57%) patients in the control group and 7 of 16 (44%) patients in the H2 group achieved a complete response (CR) or partial response (PR). In addition, 3 of 16 (19%) patients in the H2 group achieved stable disease (SD).Conclusion: The results obtained demonstrated that H2 gas inhalation therapy alleviated IMRT-induced bone marrow damage without compromising the anti-tumor effects of IMRT. The present study suggests that this novel approach of H2 gas inhalation therapy may be applicable to IMRT-induced bone marrow damage in cancer patients.

Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model

2019 ◽  
Vol 74 ◽  
pp. 105646 ◽  
Author(s):  
Peikai Huang ◽  
Shushan Wei ◽  
Weihua Huang ◽  
Penghui Wu ◽  
Shuyu Chen ◽  
...  
Keyword(s):  
Alveolar Macrophage ◽  
Hydrogen Gas ◽  
Asthma Model ◽  
Macrophage Phagocytosis ◽  
Gas Inhalation ◽  
Hydrogen Gas Inhalation

scholarly journals COMP-Ang1, Angiopoietin-1 Variant Protects Radiation-Induced Bone Marrow Damage in C57BL/6 Mice

2008 ◽  
Vol 49 (3) ◽  
pp. 313-320 ◽  
Author(s):  
Hae June LEE ◽  
Sang Woo BAE ◽  
Gou Young KOH ◽  
Yun Sil LEE
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Damage ◽  
Radiation Induced ◽  
Angiopoietin 1

scholarly journals Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice

2018 ◽  
Vol 10 (6) ◽  
pp. 3232-3243 ◽  
Author(s):  
Wenju Lu ◽  
Defu Li ◽  
Jieying Hu ◽  
Huijun Mei ◽  
Jiaze Shu ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Hydrogen Gas ◽  
Gas Inhalation ◽  
Hydrogen Gas Inhalation

Effects of Hydrogen Gas Inhalation on Endometriosis in Rats

2016 ◽  
Vol 24 (2) ◽  
pp. 324-331 ◽  
Author(s):  
Y. He ◽  
J. Z. Shi ◽  
R. J. Zhang ◽  
D. X. Zhai ◽  
D. Zhang ◽  
...  
Keyword(s):  
Hydrogen Gas ◽  
Gas Inhalation ◽  
Hydrogen Gas Inhalation
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