Association between Parkinson's Disease and Risk of Cancer: A Nationwide, Population-Based Cohort Study

2019 ◽  
Author(s):  
Joo-Hyun Park ◽  
Do-Hoon Kim ◽  
Yong-Gyu Park ◽  
Do-Young Kwon ◽  
Moonyoung Choi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Population Based ◽  
Risk Of Cancer

Parkinson’s disease and skin cancer risk: a nationwide population‐based cohort study in Korea

2020 ◽  
Vol 34 (12) ◽  
pp. 2775-2780 ◽  
Author(s):  
H.J. Ryu ◽  
J.‐H. Park ◽  
M. Choi ◽  
J.‐H. Jung ◽  
K. Han ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Skin Cancer ◽  
Cancer Risk ◽  
Population Based ◽  
Skin Cancer Risk

scholarly journals Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hsuan-Te Chu ◽  
Chih‐Sung Liang ◽  
Ta-Chuan Yeh ◽  
Li-Yu Hu ◽  
Albert C. Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Population Based

scholarly journals Tonsillectomy and risk of Parkinson's disease: A danish nationwide population-based cohort study

2017 ◽  
Vol 33 (2) ◽  
pp. 321-324 ◽  
Author(s):  
Elisabeth Svensson ◽  
Victor W. Henderson ◽  
Szimonetta Szépligeti ◽  
Morten Gersel Stokholm ◽  
Tejs Ehlers Klug ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Population Based

P3-055: Incidence of dementia in elderly Parkinson's disease: A 15-year population-based cohort study

2010 ◽  
Vol 6 ◽  
pp. S465-S465
Author(s):  
François Tison ◽  
Catherine Helmer ◽  
Florian Perez ◽  
Sophie Auriacombe ◽  
Jean-François Dartigues
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Population Based ◽  
Incidence Of Dementia

scholarly journals Risk of dementia and Parkinson’s disease in patients treated with androgen deprivation therapy using gonadotropin-releasing hormone agonist for prostate cancer: A nationwide population-based cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244660
Author(s):  
Myungsun Shim ◽  
Woo Jin Bang ◽  
Cheol Young Oh ◽  
Yong Seong Lee ◽  
Seong Soo Jeon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Propensity Score ◽  
Androgen Deprivation Therapy ◽  
Validation Cohort ◽  
Population Based ◽  
Gonadotropin Releasing Hormone ◽  
Gonadotropin Releasing Hormone Agonist

Recent studies reported conflicting results on the association of androgen deprivation therapy (ADT) with dementia and Parkinson’s disease in patients with prostate cancer (Pca). Therefore, this study aimed to investigate whether use of gonadotropin-releasing hormone agonist (GnRHa) increases the risk of both diseases. A nationwide population cohort study was conducted involving newly diagnosed patients with Pca %who started ADT with GnRHa (GnRHa users, n = 3,201) and control (nonusers, n = 4,123) between January 1, 2012, and December 31, 2016, using data from the National Health Insurance Service. To validate the result, a hospital cohort of patients with Pca consisting of GnRHa users (n = 205) and nonusers (n = 479) in a tertiary referral center from January 1, 2006 to December 31, 2016, were also analyzed. Traditional and propensity score-matched Cox proportional hazards models were used to estimate the effects of ADT on the risk of dementia and Parkinson’s disease. In univariable analysis, risk of dementia was associated with GnRHa use in both nationwide and hospital validation cohort (hazard ratio [HR], 1.696; 95% CI, 1.425–2.019, and HR, 1.352; 95% CI, 1.089–1.987, respectively). In a nationwide cohort, ADT was not associated with dementia in both traditional and propensity score-matched multivariable analysis, whereas in a hospital validation cohort, ADT was associated with dementia only in unmatched analysis (HR, 1.203; 95% CI, 1.021–1.859) but not in propensity score-matched analysis. ADT was not associated with Parkinson’s disease in either nationwide and validation cohorts. This population-based study suggests that the association between GnRHa use as ADT and increased risk of dementia or Parkinson’s disease is not clear, which was also verified in a hospital validation cohort.

scholarly journals Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study

2020 ◽  
Vol 8 (3) ◽  
pp. e000390
Author(s):  
Marc P Morissette ◽  
Heather J Prior ◽  
Robert B Tate ◽  
John Wade ◽  
Jeff R S Leiter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Study ◽  
Proportional Hazards ◽  
Geographical Location ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Control Group ◽  
Increased Risk

ObjectiveTo investigate associations between concussion and the risk of follow-up diagnoses of attention-deficit hyperactivity disorder (ADHD), mood and anxiety disorders (MADs), dementia and Parkinson’s disease.DesignA retrospective population-based cohort study.SettingAdministrative health data for the Province of Manitoba between 1990–1991 and 2014–2015.ParticipantsA total of 47 483 individuals were diagnosed with a concussion using International Classification of Diseases (ICD) codes (ICD-9-CM: 850; ICD-10-CA: S06.0). All concussed subjects were matched with healthy controls at a 3:1 ratio based on age, sex and geographical location. Associations between concussion and conditions of interest diagnosed later in life were assessed using a stratified Cox proportional hazards regression model, with adjustments for socioeconomic status and pre-existing medical conditions.Results28 021 men (mean age ±SD, 25±18 years) and 19 462 women (30±21 years) were included in the concussion group, while 81 871 men (25±18 years) and 57 159 women (30±21 years) were included in the matched control group. Concussion was associated with adjusted hazard ratios of 1.39 (95% CI 1.32 to 1.46, p<0.001) for ADHD, 1.72 (95% CI 1.69 to 1.76; p<0.001) for MADs, 1.72 (95% CI 1.61 to 1.84; p<0.001) for dementia and 1.57 (95% CI 1.41 to 1.75; p<0.001) for Parkinson’s disease.ConclusionConcussion was associated with an increased risk of diagnosis for all four conditions of interest later in life.

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