Molecular Landscapes of Embryonic and Post-Embryonic Neurogenesis in the Vertebrate Retina

2018 ◽  
Author(s):  
Baijie Xu ◽  
Xia Tang ◽  
Mengmeng Jin ◽  
Hui Zhang ◽  
Lei Du ◽  
...  
Keyword(s):  
Vertebrate Retina ◽  
Embryonic Neurogenesis

scholarly journals Adenylate Cyclase in Vertebrate Retina

1974 ◽  
Vol 249 (14) ◽  
pp. 4608-4613
Author(s):  
Marston Manthorpe ◽  
David G. McConnell
Keyword(s):  
Adenylate Cyclase ◽  
Vertebrate Retina

scholarly journals dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila

2003 ◽  
Vol 374 (2) ◽  
pp. 381-391 ◽  
Author(s):  
Pamela A. LOCHHEAD ◽  
Gary SIBBET ◽  
Ross KINSTRIE ◽  
Tava CLEGHON ◽  
Margie RYLATT ◽  
...  
Keyword(s):  
Tyrosine Phosphorylation ◽  
Protein Kinases ◽  
Mutational Analysis ◽  
Kinase Domain ◽  
Activation Loop ◽  
Embryonic Neurogenesis ◽  
Founding Family ◽  
Dual Specificity ◽  
Eukaryotic Organisms

Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs) are an emerging family of protein kinases that have been identified in all eukaryotic organisms examined to date. DYRK family members are involved in regulating key developmental and cellular processes such as neurogenesis, cell proliferation, cytokinesis and cellular differentiation. Two distinct subgroups exist, nuclear and cytosolic. In Drosophila, the founding family member minibrain, whose human orthologue maps to the Down syndrome critical region, belongs to the nuclear subclass and affects post-embryonic neurogenesis. In the present paper, we report the isolation of dDYRK2, a cytosolic DYRK and the putative product of the smell-impaired smi35A gene. This is the second such kinase described in Drosophila, but the first to be characterized at the molecular and biochemical level. dDYRK2 is an 81 kDa dual-specificity kinase that autophosphorylates on tyrosine and serine/threonine residues, but appears to phosphorylate exogenous substrates only on serine/threonine residues. It contains a YXY motif in the activation loop of the kinase domain in the same location as the TXY motif in mitogenactivated protein kinases. dDYRK2 is tyrosine-phosphorylated in vivo, and mutational analysis reveals that the activation loop tyrosines are phosphorylated and are essential for kinase activity. Finally, dDYRK2 is active at all stages of fly development, with elevated levels observed during embryogenesis and pupation.

scholarly journals Hemichannel-Mediated and pH-Based Feedback from Horizontal Cells to Cones in the Vertebrate Retina

PLoS ONE ◽  
2009 ◽  
Vol 4 (6) ◽  
pp. e6090 ◽  
Author(s):  
Iris Fahrenfort ◽  
Marvin Steijaert ◽  
Trijntje Sjoerdsma ◽  
Evan Vickers ◽  
Harris Ripps ◽  
...  
Keyword(s):  
Horizontal Cells ◽  
Vertebrate Retina

scholarly journals Muller cells are living optical fibers in the vertebrate retina

2007 ◽  
Vol 104 (20) ◽  
pp. 8287-8292 ◽  
Author(s):  
K. Franze ◽  
J. Grosche ◽  
S. N. Skatchkov ◽  
S. Schinkinger ◽  
C. Foja ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Müller Cells ◽  
Muller Cells ◽  
Vertebrate Retina
Sign in / Sign up

Export Citation Format

Share Document