Macromolecular Connectivity Landscape of Mammalian Brain

2018 ◽  
Author(s):  
Reza Pourhaghighi ◽  
Peter E. A. Ash ◽  
Sadhna Phanse ◽  
Florian Goebels ◽  
Edyta Malolepsza ◽  
...  
Keyword(s):  
Mammalian Brain

Opiate-Inhibited Adenylate Cyclase in Mammalian Brain Membranes

1986 ◽  
Author(s):  
Steven R. Childers ◽  
Peter Nijssen ◽  
Pauline Nadeau ◽  
Page Buckhannan ◽  
Phi-Van Le ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Mammalian Brain ◽  
Brain Membranes

Importance of Zebrafish as an efficient research model for the screening of novel therapeutics in neurological disorders

2020 ◽  
Vol 19 ◽  
Author(s):  
Diksha Saluja ◽  
Rishabh Jhanji ◽  
Swati Kaushal ◽  
Bharti Verma ◽  
Neelam Sharma ◽  
...  
Keyword(s):  
Animal Model ◽  
Neurological Disorders ◽  
Tropical Fish ◽  
Mammalian Brain ◽  
Behavioral Repertoire ◽  
Experimental Procedure ◽  
Novel Drugs ◽  
Associated Functions ◽  
Pharmacology And Toxicology ◽  
Rats And Mice

Abstract:: In the previous years of research, the use of animal model becomes very common for the screening of novel drugs. Animal model represents the complex problems of humans into simplest forms which can be extended further to include the experimental procedure. The most successful models in neuroscience, rats and mice, undoubtedly considered as one of the best models to understand the psychology of mammalian brain and its associated functions involved in various behavioral repertoire. Moreover, recently researchers in behavioral neuroscience are focusing more on the use of aquatic animals especially fish as model species due to their simplicity, and cost effectiveness. Zebrafish (Danio rerio) is a tropical fish from minnow family a genetic structure surprisingly 84 % similar to humans. It is gaining popularity as a model to study the mechanism in behavioral neuropharmacology. Moreover, Zebrafish is having numerous advantages over other rodent models like ease in maintenance due to their small size; breeding power is more, transparency of embryos, overall reduced cost of experimentation and many more. Nowadays, it is considered as an ideal model to study the neurobehavioral aspects with relevance to humans. It is also used in varieties of scientific studies like genetics, neuroscience, pharmacology, and toxicology. In this manuscript, we have described the feasibility and importance of Zebrafish as a model for the screening of novel drugs for different neurological disorders.

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