Engineered Nail Grafts Induce Nail Plate Regeneration Ectopically

2018 ◽  
Author(s):  
Yaling Yu ◽  
Haomin Cui ◽  
Tianyi Wu ◽  
Ruoyu Wu ◽  
Wei Chen ◽  
...  
Keyword(s):  
Nail Plate

New Topical Antifungal Penetrates Nail Plate

2006 ◽  
Vol 37 (7) ◽  
pp. 8
Author(s):  
ERIK GOLDMAN
Keyword(s):  
Nail Plate

scholarly journals A Review of Nail Changes in Acrokeratosis Paraneoplastica (Bazex Syndrome)

2021 ◽  
pp. 1-10
Author(s):  
Bipasha Roy ◽  
Shari R. Lipner
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
Nail Plate ◽  
Squamous Cell Carcinomas ◽  
Morbidity And Mortality ◽  
Cutaneous Manifestations ◽  
Nail Changes ◽  
Paraneoplastic Dermatosis ◽  
Acrokeratosis Paraneoplastica Bazex

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic dermatosis associated with internal malignancies. Clinical presentation is characterized by erythematous or violaceous scaly plaques involving the digits, nose, ears, palms, and soles. Nail changes commonly present concurrently with cutaneous manifestations. In this review, we characterize nail changes associated with acrokeratosis paraneoplastica. A total of 48 cases were analyzed. Nail findings were nonspecific, with the most common being nail plate thickening, onycholysis, subungual hyperkeratosis, longitudinal ridging, discoloration, and nail plate loss. In most patients, nail changes involved the majority of fingernails and toenails and most often appeared prior to the diagnosis of malignancy. The most common associated underlying malignancies were squamous cell carcinomas of the head and neck. A diagnosis of acrokeratosis paraneoplastica should be considered in patients with onychodystrophy involving multiple nails with accompanying atypical psoriasiform dermatoses. Screening for internal malignancies may significantly decrease morbidity and mortality for these patients.

scholarly journals The Potential of Nail Mini-Organ Stem Cells in Skin, Nail and Digit Tips Regeneration

2021 ◽  
Vol 22 (6) ◽  
pp. 2864
Author(s):  
Anna Pulawska-Czub ◽  
Tomasz D. Pieczonka ◽  
Paula Mazurek ◽  
Krzysztof Kobielak
Keyword(s):  
Stem Cells ◽  
Critical Role ◽  
Nail Plate ◽  
Molecular Characteristics ◽  
Continuous Growth ◽  
Physiological Conditions ◽  
Morphogenetic Protein ◽  
Slow Cycling ◽  
Bifunctional Properties

Nails are highly keratinized skin appendages that exhibit continuous growth under physiological conditions and full regeneration upon removal. These mini-organs are maintained by two autonomous populations of skin stem cells. The fast-cycling, highly proliferative stem cells of the nail matrix (nail stem cells (NSCs)) predominantly replenish the nail plate. Furthermore, the slow-cycling population of the nail proximal fold (nail proximal fold stem cells (NPFSCs)) displays bifunctional properties by contributing to the peri-nail epidermis under the normal homeostasis and the nail structure upon injury. Here, we discuss nail mini-organ stem cells’ location and their role in skin and nail homeostasis and regeneration, emphasizing their importance to orchestrate the whole digit tip regeneration. Such endogenous regeneration capabilities are observed in rodents and primates. However, they are limited to the region adjacent to the nail’s proximal area, indicating the crucial role of nail mini-organ stem cells in digit restoration. Further, we explore the molecular characteristics of nail mini-organ stem cells and the critical role of the bone morphogenetic protein (BMP) and Wnt signaling pathways in homeostatic nail growth and digit restoration. Finally, we investigate the latest accomplishments in stimulating regenerative responses in regeneration-incompetent injuries. These pioneer results might open up new opportunities to overcome amputated mammalian digits and limbs’ regenerative failures in the future.

scholarly journals Ultrasound Evaluation of the Effectiveness of the Use of Acitretin in the Treatment of Nail Psoriasis

2021 ◽  
Vol 10 (10) ◽  
pp. 2122
Author(s):  
Magdalena Krajewska-Włodarczyk ◽  
Zbigniew Żuber ◽  
Agnieszka Owczarczyk-Saczonek
Keyword(s):  
Morphological Changes ◽  
Nail Plate ◽  
Clinical Signs ◽  
Extensor Tendon ◽  
Control Group ◽  
Nail Bed ◽  
Nail Psoriasis ◽  
Ultrasound Evaluation ◽  
Tendon Thickness ◽  
Retinoid Treatment

The study aimed to evaluate the effect of retinoid treatment on the morphological changes in the nail apparatus in patients with nail psoriasis. Material and methods: 41 patients aged 32 to 64 with nail psoriasis, without clinical signs of psoriatic arthritis, started on acitretin 0.6 to 0.8 mg kg b.w./d, for six months and 28 people in the control group were included in the study. Both groups had ultrasound examination of fingernails and digital extensor tendon in the distal interphalangeal joints. In psoriatic patients, US examination was conducted before starting the treatment and after six months. A total of 685 nails were examined. Results: After six months of treatment, there was a reduction in the thickness of the nail bed and nail matrix (p = 0.046 and p = 0.031, respectively). The thickness of the nail plates decreased, although it was statistically insignificant (p = 0.059) and it was higher than in the control group (p = 0.034). The reduced severity of clinical nail changes after six months of retinoid treatment did not correlate with the reduction in extensor tendon thickness in any group of patients. Conclusions: In patients with nail psoriasis, acitretin treatment resulted in a rapid decrease in the thickness of the nail bed and matrix, but it did not affect the thickness of the nail plate after six months. There was no effect of acitretin on the digital extensor tendon thickness or the increased blood supply to the tendon area. The results of the study may indicate the usefulness of ultrasound nail examinations in patients with nail psoriasis not only to assess the advancement of morphological changes and response to treatment, but also to choose the potential treatment.

Individualised Homoeopathy in the Treatment of Onycholysis: An Evidence-Based Clinical Case Report

2021 ◽  
Vol 34 (03) ◽  
pp. 227-234
Author(s):  
Dhiraj Debnath ◽  
Abhiram Banerjee ◽  
Md Mostafijur Rahaman ◽  
Gurudev Choubey
Keyword(s):  
Case Report ◽  
Clinical Case ◽  
Outcome Measurement ◽  
Nail Plate ◽  
Life Quality ◽  
Well Being ◽  
Middle Finger ◽  
Final Visit ◽  
Measurement Scales ◽  
Main Complaint

Abstract Introduction Onycholysis is a chronic nail disorder characterised by the progressive separation of the nail plate from the underlying nail bed. Apart from causing pain and discomfort, it affects the quality of life of an individual due to its visualised cosmetic appearance. Case Summary A 45-year-old female presented with complete loss of nail plate of the left middle finger for 1 month. At the first visit, homoeopathic medicine Tuberculinum bovinum was prescribed and the patient was followed up periodically for 4 months. A series of photographs captured at the first visit and in subsequent visits objectively document the gradual regrowth of her nail plate. Various aspects of her subjective improvement were documented by three validated outcome measurement scales. The patient herself assessed that, after 4 months of follow-up, she is ‘back to normal’ for her main complaint as well as for the overall well-being, which is documented as a +4 score in ‘Outcome in Relation to Impact on Daily Living’ (ORIDL) scale. The Dermatology Life Quality Index (DLQI) score was reduced from 20 at the first visit to 1 after 4 months of treatment. Modified Naranjo Criteria for Homeopathy (MONARCH) score recorded at the final visit (+8 in ‘-6 to +13’ scale) is suggestive of a high likelihood that the improvement in the patient can be attributed to the homoeopathic treatment provided. Conclusion This clinical case report is presented here to critically document the effect of individualised homoeopathic treatment in onycholysis within a plausible timeframe.

Proximal nail plate destruction in subungual melanoma could be a possible predictor of invasiveness thicker than 1.25 mm

2017 ◽  
Vol 45 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Jun Young Kim ◽  
Moon-Bum Kim ◽  
Byung Cheol Park ◽  
Kee Yang Chung ◽  
You Chan Kim ◽  
...  
Keyword(s):  
Nail Plate ◽  
Subungual Melanoma

Reconstruction of Fingertip Amputations by Partial Composite Toe Transfer with Short Vascular Pedicle

1998 ◽  
Vol 23 (4) ◽  
pp. 457-464 ◽  
Author(s):  
G. DAUTEL ◽  
D. CORCELLA ◽  
M. MERLE
Keyword(s):  
Nail Plate ◽  
Surgical Reconstruction ◽  
Vascular Pedicle ◽  
Recipient Site ◽  
Fingertip Amputation ◽  
Custom Made ◽  
Initial Injury ◽  
Toe Transfer ◽  
Second Toe ◽  
Exact Amount

Five patients under 15 years-of-age, with a fingertip amputation through the nail plate, were treated with a custom-made partial toe transfer. Two of the patients hid had previous attempts at surgical reconstruction using either a local flap or replantation. Delay between initial injury and reconstruction ranged from 2 to 60 days. In all cases the flap was harvested from the second toe. This “custom-made” compound transfer included the exact amount of pulp, nail bed and bone required for reconstruction. All flaps were harvested on a short vascular pedicle, with anastomoses performed at a digital level on the recipient site. Good to excellent cosmetic results were obtained in all cases, with a nearly normal-looking fingertip. Duration of hospital stay ranged from 4 to 7 days. We recommend this technique for treatment of distal amputation close to the proximal nail fold, in young individuals.

scholarly journals Perception of brittle nails in dermatologic patients: a cross-sectional study

2013 ◽  
Vol 88 (6) ◽  
pp. 1022-1025 ◽  
Author(s):  
Giulio Cesar Gequelim ◽  
Cynthia Yone Kubota ◽  
Sarah Sanches ◽  
Daniela Dranka ◽  
Marcelo Murilo Mejia ◽  
...  
Keyword(s):  
Depressed Mood ◽  
Nail Plate ◽  
Mixed Race ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Water Contact ◽  
Cross Sectional

Brittle Nails Syndrome is characterized by fragility of the nail plate, affecting 27% of women. We evaluated dermatology patients in a cross-sectional study about perception of nail fragility. One hundred and thirtyeight women were included, with median age of 36.5 years. Nail examination showed changes in 57% and 49% reported nail fragility. The first three fingernails were the most affected. Onychoschizia was related to onychophagia (OR = 3.29), housework (OR = 2.95) and water contact (OR = 2.44). Onychorrhexis had the strongest association with nail fragility perception (OR = 17.89). The fragility was more perceived by those who were black, of mixed race and atopic, and was associated with depressed mood.

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