PTBP1 Facilitates Lymphatic Metastasis and Proliferation of Bladder Cancer Via Alternative Splicing of MEIS2 and PKM

2018 ◽  
Author(s):  
Ruihui Xie ◽  
Xu Chen ◽  
Ziyue Chen ◽  
Ming Huang ◽  
Wen Dong ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Alternative Splicing ◽  
Lymphatic Metastasis

scholarly journals NONO Inhibits Lymphatic Metastasis of Bladder Cancer via Alternative Splicing of SETMAR

2020 ◽  
Author(s):  
Ruihui Xie ◽  
Xu Chen ◽  
Liang Cheng ◽  
Ming Huang ◽  
Qianghua Zhou ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Alternative Splicing ◽  
Lymphatic Metastasis

scholarly journals RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing

Oncogene ◽  
2021 ◽  
Author(s):  
Qiuxia Yan ◽  
Peng Zeng ◽  
Xiuqin Zhou ◽  
Xiaoying Zhao ◽  
Runqiang Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Alternative Splicing ◽  
Rna Binding ◽  
Aerobic Glycolysis ◽  
Histological Grade ◽  
Migration And Invasion ◽  
Binding Motif ◽  
Hnrnp A1

AbstractThe prognosis for patients with metastatic bladder cancer (BCa) is poor, and it is not improved by current treatments. RNA-binding motif protein X-linked (RBMX) are involved in the regulation of the malignant progression of various tumors. However, the role of RBMX in BCa tumorigenicity and progression remains unclear. In this study, we found that RBMX was significantly downregulated in BCa tissues, especially in muscle-invasive BCa tissues. RBMX expression was negatively correlated with tumor stage, histological grade and poor patient prognosis. Functional assays demonstrated that RBMX inhibited BCa cell proliferation, colony formation, migration, and invasion in vitro and suppressed tumor growth and metastasis in vivo. Mechanistic investigations revealed that hnRNP A1 was an RBMX-binding protein. RBMX competitively inhibited the combination of the RGG motif in hnRNP A1 and the sequences flanking PKM exon 9, leading to the formation of lower PKM2 and higher PKM1 levels, which attenuated the tumorigenicity and progression of BCa. Moreover, RBMX inhibited aerobic glycolysis through hnRNP A1-dependent PKM alternative splicing and counteracted the PKM2 overexpression-induced aggressive phenotype of the BCa cells. In conclusion, our findings indicate that RBMX suppresses BCa tumorigenicity and progression via an hnRNP A1-mediated PKM alternative splicing mechanism. RBMX may serve as a novel prognostic biomarker for clinical intervention in BCa.

scholarly journals Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Marta Dueñas ◽  
Andrés Pérez-Figueroa ◽  
Carla Oliveira ◽  
Cristian Suárez-Cabrera ◽  
Abel Sousa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Alternative Splicing ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Gene Expression Analyses ◽  
Muscle Invasive ◽  
Tp53 Status

Alternative splicing related genetic variants contribute to bladder cancer risk

2020 ◽  
Vol 59 (8) ◽  
pp. 923-929 ◽  
Author(s):  
Zheng Guo ◽  
Huanhuan Zhu ◽  
Weidong Xu ◽  
Xi Wang ◽  
Hanting Liu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Alternative Splicing ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Bladder Cancer Risk

Modification of alternative splicing of Bcl-x pre-mRNA in bladder cancer cells

2006 ◽  
Vol 26 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Zhu Zhaohui ◽  
Xing Shian ◽  
Cheng Ping ◽  
Zeng Fuqing ◽  
Lu Gongcheng
Keyword(s):  
Bladder Cancer ◽  
Alternative Splicing ◽  
Cancer Cells ◽  
Bladder Cancer Cells

scholarly journals Epigenetic interplay between methylation and miRNA in bladder cancer: focus on isoform expression

BMC Genomics ◽  
2021 ◽  
Vol 22 (S3) ◽  
Author(s):  
Manu Shivakumar ◽  
Seonggyun Han ◽  
Younghee Lee ◽  
Dokyoon Kim
Keyword(s):  
Dna Methylation ◽  
Bladder Cancer ◽  
Alternative Splicing ◽  
Mrna Level ◽  
Genetic Regulation ◽  
Interaction Patterns ◽  
Epigenetic Factors ◽  
Regulatory Relationship ◽  
Integrative Framework ◽  
Epigenetic Regulators

Abstract Background Various epigenetic factors are responsible for the non-genetic regulation on gene expression. The epigenetically dysregulated oncogenes or tumor suppressors by miRNA and/or DNA methylation are often observed in cancer cells. Each of these epigenetic regulators has been studied well in cancer progressions; however, their mutual regulatory relationship in cancer still remains unclear. In this study, we propose an integrative framework to systematically investigate epigenetic interactions between miRNA and methylation at the alternatively spliced mRNA level in bladder cancer. Each of these epigenetic regulators has been studied well in cancer progressions; however, their mutual regulatory relationship in cancer still remains unclear. Results The integrative analyses yielded 136 significant combinations (methylation, miRNA and isoform). Further, overall survival analysis on the 136 combinations based on methylation and miRNA, high and low expression groups resulted in 13 combinations associated with survival. Additionally, different interaction patterns were examined. Conclusions Our study provides a higher resolution of molecular insight into the crosstalk between two epigenetic factors, DNA methylation and miRNA. Given the importance of epigenetic interactions and alternative splicing in cancer, it is timely to identify and understand the underlying mechanisms based on epigenetic markers and their interactions in cancer, leading to alternative splicing with primary functional impact.

scholarly journals Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

2018 ◽  
Vol 128 (2) ◽  
pp. 861-875 ◽  
Author(s):  
Wang He ◽  
Guangzheng Zhong ◽  
Ning Jiang ◽  
Bo Wang ◽  
Xinxiang Fan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymphatic Metastasis ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

2019 ◽  
Vol 130 (1) ◽  
pp. 404-421 ◽  
Author(s):  
Changhao Chen ◽  
Yuming Luo ◽  
Wang He ◽  
Yue Zhao ◽  
Yao Kong ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymphatic Metastasis ◽  
Long Noncoding Rna ◽  
Noncoding Rna
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