Effective Capture of Circulating Tumor Cells Using Electrically Charged Magnetic Nanoparticles

2018 ◽  
Author(s):  
Zhiming Li ◽  
Jun Ruan ◽  
Xuan Zhuang
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Electrically Charged

Multifunctional luminescent immuno-magnetic nanoparticles: toward fast, efficient, cell-friendly capture and recovery of circulating tumor cells

2019 ◽  
Vol 7 (3) ◽  
pp. 393-400 ◽  
Author(s):  
Xiaoxi Zhou ◽  
Bin Luo ◽  
Ke Kang ◽  
Shaohua Ma ◽  
Xiaohui Sun ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Circulating Tumor Cells

A multifunctional luminescent immuno-magnetic nanoplatform has achieved fast, efficient, cell-friendly capture and recovery of circulating tumor cells.

Simple and rapid colorimetric detection of melanoma circulating tumor cells using bifunctional magnetic nanoparticles

The Analyst ◽  
2017 ◽  
Vol 142 (24) ◽  
pp. 4788-4793 ◽  
Author(s):  
Junrong Li ◽  
Jing Wang ◽  
Yuling Wang ◽  
Matt Trau
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Colorimetric Detection ◽  
Sensitive Detection ◽  
Separation Property

The rapid and sensitive detection of melanoma circulating tumor cells was achieved utilizing the nanozyme activity and separation property of magnetic nanoparticles.

Positively Charged Magnetic Nanoparticles for Capture of Circulating Tumor Cells from Clinical Blood Samples

Nano LIFE ◽  
2020 ◽  
Vol 10 (03) ◽  
pp. 1971001 ◽  
Author(s):  
Shengming Wu ◽  
Yilong Wang ◽  
Donglu Shi
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Cell ◽  
Detection Sensitivity ◽  
Blood Samples ◽  
Charged Nanoparticles ◽  
Positively Charged

Isolation of circulating tumor cells (CTCs) from cancer patients is of high value for disease monitoring and metastasis diagnosis. Although many new detection methods have emerged in recent years, the detection of CTCs is a current challenge due to lack of specific and sensitive markers. In our previous work, cancer cell surfaces, from over 20 cancer cell lines, have been shown to be negatively-charged regardless of their phenotype by using electrically-charged nanoparticles as a probe. The strong electrostatic interaction between the negative cancer cells and positively charged nanoparticles can well remain in a physiological liquid environment in the presence of serum proteins, enabling effective binding between them. As a result, the cancer cells can be magnetically separated by employing an external magnet. In this technical report, we present preliminary results on the investigation of CTC isolation from both mimetic and clinical blood samples. We show high CTC detection sensitivity by the positively-charged magnetic nanoparticles (PMNs) even at the original concentration of 10 cells per mL mimetic blood sample. The CTCs in the peripheral blood of colorectal cancer patients were isolated and identified by cellular morphology and immunofluorescence staining.

Peptide-based isolation of circulating tumor cells by magnetic nanoparticles

2014 ◽  
Vol 2 (26) ◽  
pp. 4080-4088 ◽  
Author(s):  
Linling Bai ◽  
Yimeng Du ◽  
Jiaxi Peng ◽  
Yi Liu ◽  
Yanmei Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
High Efficiency ◽  
Isolation Method ◽  
Functionalized Magnetic Nanoparticles

A new CTC isolation method with high efficiency by using EpCAM recognition peptide functionalized magnetic nanoparticles was developed.

scholarly journals Magnetic Particles for CTC Enrichment

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3525
Author(s):  
Peng Liu ◽  
Pascal Jonkheijm ◽  
Leon W. M. M. Terstappen ◽  
Michiel Stevens
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Magnetic Separation ◽  
Circulating Tumor Cells ◽  
Magnetic Particles ◽  
Separation Techniques ◽  
Specific Antibodies ◽  
Immunomagnetic Enrichment ◽  
Different Characteristics

Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.

Antifouling hydrogel-coated magnetic nanoparticles for selective isolation and recovery of circulating tumor cells

2021 ◽  
Author(s):  
Zhili Wang ◽  
Zeen Wu ◽  
Na Sun ◽  
Yi Cao ◽  
Xue Cai ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Selective Isolation

The antifouling hydrogel-coated magnetic nanoparticles were developed to realize the cell-friendly and efficient CTC capture and recovery.

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