Transcriptome Profiling of Hepatocellular Carcinoma Uncovers Multi-Types of Dysregulated ncRNAs

2018 ◽  
Author(s):  
Li Zhang ◽  
Chunmei Wang ◽  
Chenkai Lv ◽  
Xiaojie Lu ◽  
Xiao Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcriptome Profiling

scholarly journals Transcriptome profiling identifies a recurrent CRYL1-IFT88 chimeric transcript in hepatocellular carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 40693-40704 ◽  
Author(s):  
Yi Huang ◽  
Jiaying Zheng ◽  
Dunyan Chen ◽  
Feng Li ◽  
Wenbing Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcriptome Profiling ◽  
Chimeric Transcript

scholarly journals Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176562 ◽  
Author(s):  
Eric C. Sorenson ◽  
Raya Khanin ◽  
Zubin M. Bamboat ◽  
Michael J. Cavnar ◽  
Teresa S. Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcriptome Profiling ◽  
Fibrolamellar Hepatocellular Carcinoma

scholarly journals Immune Cell Composition of Liver Hepatocellular Carcinoma and its clinical relevance: A research based on TCGA database

2019 ◽  
Author(s):  
Yucheng Ji ◽  
Guang-xiang Gu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cells ◽  
Survival Time ◽  
Clinical Data ◽  
Immune Cells ◽  
Immune Cell ◽  
Transcriptome Profiling ◽  
Statistical Analyses ◽  
Lower Amount ◽  
Liver Hepatocellular Carcinoma

Abstract Background Liver hepatocellular carcinoma (LIHC), as the main type of liver cancer, has become a main health issue as the third-most common cause of mortality in cancer patients. However, conventional chemo- or radio- therapies shows little improvement in survival, which calls for novel therapies. Because of the immunotolerance mechanism existing naturally in liver, immunotherapy provides significant effect in treatment of LIHC patients. Up to now, various immunotherapies have been proposed, but due to the complex pathways from which LIHC cancerous cell escape immunosurveillance, combined therapies are often needed, which are still under development. Methods In the current study, with data downloaded from TCGA database, CIBERSORT was performed for identifying the composition of infiltrating immune cells and further statistical analyses using R 3.5.3 were carried out, aiming at connecting specific immune cells with clinical survival. Results With data of immune and stromal scores downloaded from the website of MD Anderson Cancer Centre, both showed significance in survival time. Further analyses based on the result of CIBERSORT demonstrated that the number of macrophages M0 and T cells CD8 infiltration between para-carcinoma and tumour tissues are markedly different. With combination of clinical data, we were able to identify that a higher amount of activated NK cells (p=0.008) and a lower amount of resting NK cells (p=0.047) presented a longer survival time. Conclusion With the help of the TCGA database and multiple techniques, statistical analyses of transcriptome profiling data and clinical data were successfully carried out. The results in this study may pave the way for a new therapeutic strategy which could be combined with current treatments to further improve the clinical outcome of LIHC patients. Further and deeper investigation of other available data, however, were needed in order to verify the results of current study.

scholarly journals Genomic and transcriptome profiling identified both human and HBV genetic variations and their interactions in Chinese hepatocellular carcinoma

Genomics Data ◽  
2015 ◽  
Vol 6 ◽  
pp. 1-3 ◽  
Author(s):  
Hua Dong ◽  
Ziliang Qian ◽  
Lan Zhang ◽  
Yunqin Chen ◽  
Zhenggang Ren ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcriptome Profiling ◽  
Genetic Variations

Multimodality treatment of hepatocellular carcinoma

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S315-S319 ◽  
Author(s):  
ZHAO-YOU TANG ◽  
XIN-DA ZHOU ◽  
ZENG-CHEN MA ◽  
ZHI-QUAN WU ◽  
JIA FAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multimodality Treatment

Hepatocellular carcinoma

1982 ◽  
Vol 118 (1) ◽  
pp. 69-70 ◽  
Author(s):  
A. J. Bennett
Keyword(s):  
Hepatocellular Carcinoma

Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplanation

2001 ◽  
Vol 120 (5) ◽  
pp. A90-A90
Author(s):  
N ESNAOLA ◽  
G LAUWERS ◽  
N MIRZA ◽  
D NAGORNEY ◽  
D DOHERTY ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion
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