HSF1 is a Direct, Master AMPK Antagonist to Control Protein Cholesteroylation

2018 ◽  
Author(s):  
Kuo-Hui Su ◽  
Siyuan Dai ◽  
Zijian Tang ◽  
Chengkai Dai
Keyword(s):  
Control Protein

scholarly journals Disabling complement regulatory activities of vaccinia virus complement control protein reduces vaccinia virus pathogenicity

Vaccine ◽  
2011 ◽  
Vol 29 (43) ◽  
pp. 7435-7443 ◽  
Author(s):  
John Bernet ◽  
Muzammil Ahmad ◽  
Jayati Mullick ◽  
Yogesh Panse ◽  
Akhilesh K. Singh ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Complement Control Protein ◽  
Control Protein

Control of the glycolytic gapA operon by the catabolite control protein A in Bacillus subtilis: a novel mechanism of CcpA-mediated regulation

2002 ◽  
Vol 45 (2) ◽  
pp. 543-553 ◽  
Author(s):  
Holger Ludwig ◽  
Nicole Rebhan ◽  
Hans-Matti Blencke ◽  
Matthias Merzbacher ◽  
Jorg Stulke
Keyword(s):  
Bacillus Subtilis ◽  
Protein A ◽  
Catabolite Control Protein A ◽  
Control Protein ◽  
Catabolite Control

Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion

2012 ◽  
Vol 12 (7) ◽  
pp. 926-936 ◽  
Author(s):  
Ning Zhang ◽  
Tilo Pompe ◽  
Ihsan Amin ◽  
Robert Luxenhofer ◽  
Carsten Werner ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Protein Adsorption ◽  
Polymer Brushes ◽  
Control Protein

scholarly journals Genetic and Biochemical Evaluation of the Importance of Cdc6 in Regulating Mitotic Exit

2003 ◽  
Vol 14 (11) ◽  
pp. 4592-4604 ◽  
Author(s):  
Vincent Archambault ◽  
Caihong X. Li ◽  
Alan J. Tackett ◽  
Ralph Wäsch ◽  
Brian T. Chait ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Mitotic Exit ◽  
Terminal Region ◽  
Cyclin Dependent Kinase ◽  
Replication Control ◽  
Mitotic Cyclin ◽  
Biochemical Evaluation ◽  
Inhibitory Domain ◽  
Late Mitosis ◽  
Control Protein

We evaluated the hypothesis that the N-terminal region of the replication control protein Cdc6 acts as an inhibitor of cyclin-dependent kinase (Cdk) activity, promoting mitotic exit. Cdc6 accumulation is restricted to the period from mid-cell cycle until the succeeding G1, due to proteolytic control that requires the Cdc6 N-terminal region. During late mitosis, Cdc6 is present at levels comparable with Sic1 and binds specifically to the mitotic cyclin Clb2. Moderate overexpression of Cdc6 promotes viability of CLB2Δdb strains, which otherwise arrest at mitotic exit, and rescue is dependent on the N-terminal putative Cdk-inhibitory domain. These observations support the potential for Cdc6 to inhibit Clb2-Cdk, thus promoting mitotic exit. Consistent with this idea, we observed a cytokinesis defect in cdh1Δ sic1Δ cdc6Δ2–49 triple mutants. However, we were able to construct viable strains, in three different backgrounds, containing neither SIC1 nor the Cdc6 Cdk-inhibitory domain, in contradiction to previous work. We conclude, therefore, that although both Cdc6 and Sic1 have the potential to facilitate mitotic exit by inhibiting Clb2-Cdk, mitotic exit nevertheless does not require any identified stoichiometric inhibitor of Cdk activity.

Optobiochemistry: Genetically Encoded Control of Protein Activity by Light

2021 ◽  
Vol 90 (1) ◽  
Author(s):  
Jihye Seong ◽  
Michael Z. Lin
Keyword(s):  
Protein Function ◽  
Living Cells ◽  
Optical Methods ◽  
Annual Review ◽  
Publication Date ◽  
Protein Activity ◽  
Spatiotemporal Resolution ◽  
Protein Functions ◽  
Protein Classes ◽  
Control Protein

Optobiochemical control of protein activities allows the investigation of protein functions in living cells with high spatiotemporal resolution. Over the last two decades, numerous natural photosensory domains have been characterized and synthetic domains engineered and assembled into photoregulatory systems to control protein function with light.Here, we review the field of optobiochemistry, categorizing photosensory domains by chromophore, describing photoregulatory systems by mechanism of action, and discussing protein classes frequently investigated using optical methods. We also present examples of how spatial or temporal control of proteins in living cells has provided new insights not possible with traditional biochemical or cell biological techniques. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Effect of mineral protein suplements on live weight gain of grazing cattle

2009 ◽  
Vol 33 (6) ◽  
pp. 1643-1648
Author(s):  
Lucas Alberto Teixeira de Rezende ◽  
Júlio César Teixeira ◽  
Antônio Ricardo Evangelista ◽  
Juan Ramón Olalquiaga Pérez ◽  
Joel Augusto Muniz ◽  
...  
Keyword(s):  
Weight Gain ◽  
Live Weight ◽  
Mineral Salt ◽  
Daily Weight Gain ◽  
Average Weight ◽  
Protein Supplement ◽  
Protein Nitrogen ◽  
Live Weight Gain ◽  
Grazing Cattle ◽  
Control Protein

This work was carried out to evaluate the effect of supplements based on non-protein nitrogen (NPN) as: urea, amirea and multinutritional block, on live weight gain and cost analysis for cattle kept in pastures. During a period of 104 days(April to July 2004), 40 crossbreed bulls, uncastrated and initial average weight of 379kg, were allocated into 4 paddocks with Brachiaria brizantha cv. Marandu, in continuous pasture system receiving, in troughs, the following treatments: mineral salt (control), protein supplement containing amirea, protein supplement containing urea and multinutritional block. The experimental design used was randomized blocks with repetition within the block. Results of availability bromatological composition of pasture, supplement consumption and daily weight gain of animals were evaluated in two experimental sub-periods: 0 to 45 and 45 to 90 days. In the first sub-period, there was no effect of treatments (P>0.05) on daily weight gain but in the second sub-period, the multinutritional block showed smaller (P<0.05) weight gain than the ones which were similar among themselves, being: 0.60; 0.59; 0.61 and 0.22kg/animal/day, respectively, for the treatments with mineral salt, amirea, urea and multinutritional block. Before these edafoclimatic conditions, the period and duration of the experiment, the supplementation with mineral salt provided the higher profit.

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