Hepatocyte Growth Factor Regulates Macrophage Transition to the M2 Phenotype and Promotes Murine Skeletal Muscle Regeneration

2018 ◽  
Author(s):  
Wooshik Choi ◽  
Jaeman Lee ◽  
Junghun Lee ◽  
Sang Hwan Lee ◽  
Sunyoung Kim
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Murine Skeletal Muscle ◽  
Hepatocyte Growth ◽  
M2 Phenotype

scholarly journals Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration

Blood ◽  
2009 ◽  
Vol 114 (24) ◽  
pp. 5052-5061 ◽  
Author(s):  
Thomas H. Sisson ◽  
Mai-Huong Nguyen ◽  
Bi Yu ◽  
Margaret L. Novak ◽  
Richard H. Simon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Muscle Regeneration ◽  
Wild Type ◽  
Blocking Antibody ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Hepatocyte Growth ◽  
Pai 1

Abstract The plasminogen system plays a crucial role in the repair of a variety of tissues, including skeletal muscle. We hypothesized that urokinase-type plasminogen activator (uPA) promotes muscle regeneration by activating hepatocyte growth factor (HGF), which, in turn, stimulates proliferation of myoblasts required for regeneration. In our studies, levels of active HGF and phosphorylation of the HGF receptor c-met were increased after muscle injury in wild-type mice. Compared with wild-type animals, mice deficient in uPA (uPA−/−) had markedly reduced HGF levels and c-met activation after muscle damage. This reduced HGF activity in uPA−/− animals was associated with decreased cell proliferation, myoblast accumulation, and new muscle fiber formation. On the other hand, HGF activity was enhanced at early time points in PAI-1−/− mice compared with wild-type mice and the PAI-1−/− animals exhibited accelerated muscle fiber regeneration. Furthermore, administration of exogenous uPA rescued HGF levels and muscle regeneration in uPA−/− mice, and an HGF-blocking antibody reduced HGF activity and muscle regeneration in wild-type mice. We also found that uPA promotes myoblast proliferation in vitro through its proteolytic activity, and this process was inhibited by an HGF-blocking antibody. Together, our findings demonstrate that uPA promotes muscle regeneration through HGF activation and subsequent myoblast proliferation.

scholarly journals Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration

Immunity ◽  
2016 ◽  
Vol 45 (5) ◽  
pp. 1038-1051 ◽  
Author(s):  
Tamas Varga ◽  
Rémi Mounier ◽  
Andreas Patsalos ◽  
Péter Gogolák ◽  
Matthew Peloquin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Transcription Factor ◽  
Growth Factor ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

scholarly journals Expression of Hepatocyte Growth Factor in Rat Skeletal Muscle

2005 ◽  
Vol 17 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Shoji Tanaka ◽  
Junji Tanaka ◽  
Ei Kawahara ◽  
Hiroshi Funakoshi ◽  
Toshikazu Nakamura ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Rat Skeletal Muscle ◽  
Hepatocyte Growth

Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro

1995 ◽  
Vol 165 (2) ◽  
pp. 307-312 ◽  
Author(s):  
Ronald E. Allen ◽  
Shannon M. Sheehan ◽  
Richard G. Taylor ◽  
Teresa L. Kendall ◽  
Glenna M. Rice
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Satellite Cells ◽  
Muscle Satellite Cells ◽  
Skeletal Muscle Satellite Cells ◽  
Hepatocyte Growth

scholarly journals Vascular endothelial growth factor stimulates skeletal muscle regeneration in Vivo

2004 ◽  
Vol 10 (5) ◽  
pp. 844-854 ◽  
Author(s):  
Nikola Arsic ◽  
Serena Zacchigna ◽  
Lorena Zentilin ◽  
Genaro Ramirez-Correa ◽  
Lucia Pattarini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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