scholarly journals Notch2 Signaling Regulates Id4 and Cell Cycle Genes to Maintain Neural Stem Cell Quiescence in the Adult Hippocampus

2018 ◽  
Author(s):  
Runrui Zhang ◽  
Marcelo Boareto ◽  
Anna Engler ◽  
Angeliki Louvi ◽  
Claudio Giachino ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Cycle Genes ◽  
Stem Cell Quiescence ◽  
Cell Quiescence ◽  
Adult Hippocampus

scholarly journals Notch2 signaling regulates Id4 and cell cycle genes to maintain neural stem cell quiescence in the adult hippocampus

2018 ◽  
Author(s):  
Runrui Zhang ◽  
Marcelo Boareto ◽  
Anna Engler ◽  
Angeliki Louvi ◽  
Claudio Giachino ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Stem Cell ◽  
Hippocampal Dentate Gyrus ◽  
Cell Cycle Genes ◽  
Stem Cell Quiescence ◽  
Activated State ◽  
Cell Quiescence ◽  
Age Dependent ◽  
Adult Hippocampus

SummaryNeural stem cells (NSCs) in the adult hippocampal dentate gyrus (DG) can be quiescent or proliferative, but how they are maintained is largely unknown. With age DG NSCs become increasingly dormant, which impinges on neuron generation. We addressed how NSC activity is controlled and found that Notch2 promotes quiescence by regulating their transition to the activated state. Notch2-ablation induces cell cycle genes and markers of active NSCs. Conversely, quiescent NSC-associated genes, including Id4, are down regulated after Notch2 deletion. We found that Notch2 binds the Id4 promoter and positively regulates transcription. Similar to Notch2, Id4 overexpression promotes DG NSC quiescence and Id4 knockdown rescues proliferation, even when Notch2 signaling is activated. We show that Notch2 regulates age-dependent DG NSC dormancy and Notch2 inhibition rejuvenates neurogenesis in the DG of aged mice. Our data indicate that a Notch2-Id4 axis promotes adult DG NSC quiescence and dormancy.

scholarly journals Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus

Cell Reports ◽  
2019 ◽  
Vol 28 (6) ◽  
pp. 1485-1498.e6 ◽  
Author(s):  
Runrui Zhang ◽  
Marcelo Boareto ◽  
Anna Engler ◽  
Angeliki Louvi ◽  
Claudio Giachino ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Quiescence ◽  
Cell Quiescence ◽  
Adult Hippocampus

scholarly journals CHD7 Maintains Neural Stem Cell Quiescence and Prevents Premature Stem Cell Depletion in the Adult Hippocampus

Stem Cells ◽  
2014 ◽  
Vol 33 (1) ◽  
pp. 196-210 ◽  
Author(s):  
Kieran M. Jones ◽  
Nemanja Sarić ◽  
John P. Russell ◽  
Cynthia L. Andoniadou ◽  
Peter J. Scambler ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Depletion ◽  
Stem Cell Quiescence ◽  
Cell Quiescence ◽  
Adult Hippocampus

scholarly journals Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

2020 ◽  
Vol 26 (4) ◽  
pp. 558-568.e9 ◽  
Author(s):  
Christopher S. Morrow ◽  
Tiaira J. Porter ◽  
Nan Xu ◽  
Zachary P. Arndt ◽  
Kayla Ako-Asare ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Protein Turnover ◽  
Stem Cell Quiescence ◽  
Cell Quiescence

scholarly journals Hippo pathway regulates neural stem cell quiescence

Cell Cycle ◽  
2016 ◽  
Vol 15 (12) ◽  
pp. 1525-1526 ◽  
Author(s):  
Rouven Ding ◽  
Christian Berger
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Hippo Pathway ◽  
Stem Cell Quiescence ◽  
Cell Quiescence

scholarly journals Protein S Regulates Neural Stem Cell Quiescence and Neurogenesis

Stem Cells ◽  
2016 ◽  
Vol 35 (3) ◽  
pp. 679-693 ◽  
Author(s):  
Katya Zelentsova ◽  
Ziv Talmi ◽  
Ghada Abboud-Jarrous ◽  
Tamar Sapir ◽  
Tal Capucha ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Protein S ◽  
Stem Cell Quiescence ◽  
Cell Quiescence

scholarly journals p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis

2013 ◽  
Vol 32 (7) ◽  
pp. 970-981 ◽  
Author(s):  
Shohei Furutachi ◽  
Akinobu Matsumoto ◽  
Keiichi I Nakayama ◽  
Yukiko Gotoh
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Adult Neural Stem Cell ◽  
Stem Cell Quiescence ◽  
Cell Quiescence

scholarly journals Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence

2013 ◽  
Vol 27 (16) ◽  
pp. 1769-1786 ◽  
Author(s):  
B. Martynoga ◽  
J. L. Mateo ◽  
B. Zhou ◽  
J. Andersen ◽  
A. Achimastou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Quiescence ◽  
Cell Quiescence
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