Potential of Serum Gastrokine 1 (GKN1) Protein for the Early Detection of Gastric Cancer

2018 ◽  
Author(s):  
JungHwan Yoon ◽  
Suk Woo Nam ◽  
Won Sang Park
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Gastrokine 1

Effect of periodic endoscopy for gastric cancer on early detection and improving survival

2001 ◽  
Vol 120 (5) ◽  
pp. A606-A606
Author(s):  
Y MORII ◽  
T YOSHIDA ◽  
T MATSUMATA ◽  
T ARITA ◽  
K SHIMODA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection

scholarly journals Early Detection is Important to Reduce the Economic Burden of Gastric Cancer

2018 ◽  
Vol 18 (1) ◽  
pp. 82 ◽  
Author(s):  
Jie-Hyun Kim ◽  
Sung Soo Kim ◽  
Jeong Hoon Lee ◽  
Da Hyun Jung ◽  
Dae Young Cheung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Economic Burden

Ectopic expression of gastrokine 1 in gastric cancer cells up-regulates tight and adherens junction proteins network

2015 ◽  
Vol 211 (8) ◽  
pp. 577-583 ◽  
Author(s):  
Emilia Rippa ◽  
Filomena Altieri ◽  
Chiara Stella Di Stadio ◽  
Giuseppina Miselli ◽  
Annalisa Lamberti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Ectopic Expression ◽  
Adherens Junction ◽  
Gastric Cancer Cells ◽  
Gastrokine 1 ◽  
Adherens Junction Proteins ◽  
Junction Proteins

Tu1308 Methylation Analysis of Gastric Juice-derived Exosomal DNA is Useful for Early Detection of Gastric Cancer

2016 ◽  
Vol 150 (4) ◽  
pp. S871
Author(s):  
Hiroyuki Yamamoto ◽  
Yoshihito Yoshida ◽  
Ryo Morita ◽  
Ritsuko Oikawa ◽  
Tadateru Maehata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Gastric Juice ◽  
Methylation Analysis

scholarly journals Identification of Early Diagnostic and Prognostic Biomarkers via WGCNA in Stomach Adenocarcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Ruoyue Tan ◽  
Guanghui Zhang ◽  
Ruochen Liu ◽  
Jianbing Hou ◽  
Zhen Dong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Extracellular Matrix ◽  
Early Detection ◽  
Early Stage ◽  
Gene Set Enrichment Analysis ◽  
Stage I ◽  
Tyrosine Kinase Receptor ◽  
Stomach Adenocarcinoma ◽  
Early Diagnostic ◽  
Potential Biomarkers

Stomach adenocarcinoma (STAD) is a leading cause of cancer deaths, and the outcome of the patients remains dismal for the lack of effective biomarkers of early detection. Recent studies have elucidated the landscape of genomic alterations of gastric cancer and reveal some biomarkers of advanced-stage gastric cancer, however, information about early-stage biomarkers is limited. Here, we adopt Weighted Gene Co-expression Network Analysis (WGCNA) to screen potential biomarkers for early-stage STAD using RNA-Seq and clinical data from TCGA database. We find six gene clusters (or modules) are significantly correlated with the stage-I STADs. Among these, five hub genes, i.e., MS4A1, THBS2, VCAN, PDGFRB, and KCNA3 are identified and significantly de-regulated in the stage-I STADs compared with the normal stomach gland tissues, which suggests they can serve as potential early diagnostic biomarkers. Moreover, we show that high expression of VCAN and PDGFRB is associated with poor prognosis of STAD. VCAN encodes a large chondroitin sulfate proteoglycan that is the main component of the extracellular matrix, and PDGFRB encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. Consistently, Gene Ontology (GO) analysis of differentially expressed genes in the STADs indicates terms associated with extracellular matrix and receptor ligand activity are significantly enriched. Protein-protein network interaction analysis (PPI) and Gene Set Enrichment Analysis (GSEA) further support the core role of VCAN and PDGFRB in the tumorigenesis. Collectively, our study identifies the potential biomarkers for early detection and prognosis of STAD.

scholarly journals Intestinal Metaplasia Related to Gastric Cancer: An Outcome Analysis of Biomarkers for Early Detection

10.5772/52958 ◽  
2013 ◽  
Author(s):  
Jiro Watari ◽  
Kentaro Moriichi ◽  
Hiroki Tanabe ◽  
Mikihiro Fujiya ◽  
Hiroto Miwa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Detection ◽  
Intestinal Metaplasia ◽  
Outcome Analysis
Sign in / Sign up

Export Citation Format

Share Document