FDG-PET/CT for Detecting an Infection Focus in Patients with a Bloodstream Infection: Factors Affecting Diagnostic Yield

2018 ◽  
Author(s):  
Jordy Pijl ◽  
Andor Glaudemans ◽  
Riemer Slart ◽  
Derya Yakar ◽  
Marjan Wouthuyzen-Bakker ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Fdg Pet ◽  
Diagnostic Yield ◽  
Factors Affecting ◽  
Pet Ct ◽  
Infection Focus ◽  
Fdg Pet Ct

scholarly journals FDG-PET/CT in intensive care patients with bloodstream infection

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Jordy P. Pijl ◽  
Mark Londema ◽  
Thomas C. Kwee ◽  
Maarten W. N. Nijsten ◽  
Riemer H. J. A. Slart ◽  
...  
Keyword(s):  
Intensive Care ◽  
Image Quality ◽  
Fdg Pet ◽  
Diagnostic Yield ◽  
Unknown Origin ◽  
Intensive Care Patients ◽  
Pet Ct ◽  
Infection Focus ◽  
Focus Of Infection ◽  
Fdg Pet Ct

Abstract Background 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI. Methods In this retrospective cohort study, all intensive care patients from our Dutch university medical center who had culture-proven BSI between 2010 and 2020 and underwent FDG-PET/CT to find the focus of infection were included. Diagnostic performance was calculated and logistic regression analysis was performed to evaluate the association between FDG-PET/CT outcome and C-reactive protein level (CRP), leukocyte count, duration of antibiotic treatment, duration of ICU stay, quality of FDG-PET/CT, and dependency on mechanical ventilation. In addition, the impact of FDG-PET/CT on clinical treatment was evaluated. Results 30 intensive care patients with BSI were included. In 21 patients, an infection focus was found on FDG-PET/CT which led to changes in clinical management in 14 patients. FDG-PET/CT achieved a sensitivity of 90.9% and specificity of 87.5% for identifying the focus of infection. Poor quality of the FDG-PET images significantly decreased the likelihood of finding an infection focus as compared to reasonable or good image quality (OR 0.16, P = 0.034). No other variables were significantly associated with FDG-PET/CT outcome. No adverse events during the FDG-PET/CT procedure were reported. Conclusion FDG-PET/CT has a high diagnostic yield for detecting the infection focus in patients with BSI admitted to intensive care. Poor PET image quality was significantly associated with a decreased likelihood of finding the infection focus in patients with BSI. This could be improved by adequate dietary preparation and cessation of intravenous glucose and glucose-regulating drugs. Recent advances in PET/CT technology enable higher image quality with shorter imaging time and may contribute to routinely performing FDG-PET/CT in intensive care patients with BSI of unknown origin.

FDG-PET/CT for Detecting an Infection Focus in Patients With Bloodstream Infection

2019 ◽  
Vol 44 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Jordy P. Pijl ◽  
Andor W. J. M. Glaudemans ◽  
Riemer H. J. A. Slart ◽  
Derya Yakar ◽  
Marjan Wouthuyzen-Bakker ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Fdg Pet ◽  
Pet Ct ◽  
Infection Focus ◽  
Fdg Pet Ct

scholarly journals Prognostic value of metabolic parameters on 18F-fluorodeoxyglucose positron tomography/computed tomography in classical rectal adenocarcinoma

2021 ◽  
Author(s):  
Byung Wook Choi ◽  
Sungmin Kang ◽  
Sung Uk Bae ◽  
Woon Kyung Jeong ◽  
Seong Kyu Baek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Prognostic Factors ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Univariate Analysis ◽  
Rectal Adenocarcinoma ◽  
Metabolic Parameters ◽  
Factors Affecting ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract We aimed to investigate the prognostic value of the metabolic parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in classical rectal adenocarcinoma (CRAC). We retrospectively reviewed 149 patients with CRAC who underwent preoperative 18F-FDG PET/CT at initial diagnosis followed by curative surgical resection. 18F-FDG PET/CT metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) for disease-free survival (DFS) and overall survival (OS) were evaluated for prognostic significance by univariate and multivariate analyses, along with conventional risk factors including pathologic T (pT) stage, lymph node (LN) metastasis, lymphovascular invasion (LVI), perineural invasion (PNI), and preoperative carcinoembryonic antigen (CEA) level. On univariate analysis, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG were significant prognostic factors affecting DFS (all P < 0.05), while CEA level, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG affected OS (all P < 0.05). On multivariate analysis, positive LN metastasis, LVI, MTV, and TLG were independent prognostic factors affecting DFS (all P < 0.05), while CEA level, positive LN metastasis, and MTV affected OS (all P < 0.05). Thus, MTV and TLG are independent prognostic factors for DFS and OS in CRAC patients.

Diagnostic yield of 18 F‐FDG PET/CT imaging and urinary CXCL9/creatinine levels in kidney allograft subclinical rejection

2020 ◽  
Vol 20 (5) ◽  
pp. 1402-1409 ◽  
Author(s):  
Oriane Hanssen ◽  
Laurent Weekers ◽  
Pierre Lovinfosse ◽  
Alexandre Jadoul ◽  
Catherine Bonvoisin ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Diagnostic Yield ◽  
Ct Imaging ◽  
Kidney Allograft ◽  
Pet Ct ◽  
Subclinical Rejection ◽  
Fdg Pet Ct

Diagnostic yield of FDG-PET/CT in fever of unknown origin: a systematic review, meta-analysis, and Delphi exercise

2018 ◽  
Vol 73 (6) ◽  
pp. 588-589 ◽  
Author(s):  
I.J.E. Kouijzer ◽  
J.W.M. van der Meer ◽  
W.J.G. Oyen ◽  
C.P. Bleeker-Rovers
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Diagnostic Yield ◽  
Meta Analysis ◽  
Unknown Origin ◽  
Pet Ct ◽  
Delphi Exercise ◽  
Fdg Pet Ct

scholarly journals Metastatic bone tumors: Analysis of factors affecting prognosis and efficacy of CT and 18F-FDG PET-CT in identifying primary lesions

2014 ◽  
Vol 2 (5) ◽  
pp. 875-881 ◽  
Author(s):  
HIROFUMI SHIMADA ◽  
TAKAO SETOGUCHI ◽  
MASAHIRO YOKOUCHI ◽  
HIROMI SASAKI ◽  
YASUHIRO ISHIDOU ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Bone Tumors ◽  
Factors Affecting ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic yield of 18F-FDG PET/CT in suspected diagnosis of vascular graft infection: A prospective cohort study

2018 ◽  
Vol 27 (1) ◽  
pp. 294-302 ◽  
Author(s):  
Hans Bowles ◽  
◽  
Juan Ambrosioni ◽  
Gaspar Mestres ◽  
Marta Hernández-Meneses ◽  
...  
Keyword(s):  
Cohort Study ◽  
Fdg Pet ◽  
Vascular Graft ◽  
Diagnostic Yield ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Suspected Diagnosis

scholarly journals The role of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in the differential diagnosis of pericardial disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Cheol Won Hyeon ◽  
Hyun Kyung Yi ◽  
Eun Kyoung Kim ◽  
Sung-Ji Park ◽  
Sang-Chol Lee ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Fdg Pet ◽  
Diagnostic Yield ◽  
Emission Tomography ◽  
Pericardial Disease ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Pet Ct ◽  
Fdg Pet Ct

AbstractThis study aimed to assess the role of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18FDG-PET/CT) in the differential diagnosis of pericardial disease. The diagnosis is often troublesome because pericardial fluid analysis or biopsy does not always provide answers. 18FDG-PET/CT can visualize both inflammation and malignancy and offers a whole-body assessment. Patients who visited the Pericardial Disease Clinic of Samsung Medical Center with an 18FDG-PET/CT order code were extracted. Exclusion criteria were as follows: (1) the purpose of the differential diagnosis was not pericardial disease; (2) the patient had a known advanced-stage malignancy; (3) the patient already have confirmative diagnosis using a serology, pericardial effusion analysis or biopsy. The analysis included 107 patients. The most common final diagnosis was idiopathic (n = 46, 43.0%), followed by tuberculosis (n = 30, 28.0%) and neoplastic (n = 11, 10.3%). A maximum standardized uptake value (SUVmax) ≥ 5 typically indicates tuberculosis or neoplastic pericarditis except in just one case of autoimmune pericarditis); especially all of the SUVmax scores ≥ 10 had tuberculosis. The diagnostic yield of pericardial biopsy was very low (10.2%). Interestingly, all of the pericardium with an SUVmax < 4.4 had nondiagnostic results. In contrast, targeted biopsies based on 18FDG uptake demonstrated a higher diagnostic yield (38.7%) than pericardium. The sensitivity of 18FDG-PET/CT was 63.6%. The specificity was 71.9%. The positive predictive value was 20.6%. The negative predictive value 94.5%, and the accuracy was 71.0% for excluding malignancy based upon the FDG uptake patterns. It is possible to explore the differential diagnosis in some patients with difficult pericardiocentesis or pericardial biopsy in a noninvasive manner using on the SUVmax or uptake patterns. In addition, the biopsy strategy depending on 18FDG uptake is helpful to achieve biopsy more safely and with a higher yield. 18FDG-PET may enhance the diagnostic efficacy in patients with pericardial disease.

scholarly journals Series of myocardial FDG uptake requiring considerations of myocardial abnormalities in FDG-PET/CT

2021 ◽  
Author(s):  
Ryogo Minamimoto
Keyword(s):  
Fdg Pet ◽  
Patient Management ◽  
Underlying Disease ◽  
Cardiac Pet ◽  
Factors Affecting ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Fdg Pet Ct

AbstractDistinct from cardiac PET performed with preparation to control physiological FDG uptake in the myocardium, standard FDG-PET/CT performed with 4–6 h of fasting will show variation in myocardial FDG uptake. For this reason, important signs of myocardial and pericardial abnormality revealed by myocardial FDG uptake tend to be overlooked. However, recognition of possible underlying disease will support further patient management to avoid complications due to the disease. This review demonstrates the mechanism of FDG uptake in the myocardium, discusses the factors affecting uptake, and provides notable image findings that may suggest underlying disease.

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