Relationship between DNA Methylation in Long Non-Coding RNA ANRIL and Coronary Artery Disease

2018 ◽  
Author(s):  
Chen-Hui Zhao ◽  
Jing Zhang ◽  
Qiao-Wei Jia ◽  
Feng-Hui An ◽  
Zhao-Hong Chen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Dna Methylation ◽  
Coronary Artery ◽  
Non Coding Rna ◽  
Artery Disease ◽  
Long Non Coding Rna

scholarly journals Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Bayi Xu ◽  
Zhixia Xu ◽  
Yequn Chen ◽  
Nan Lu ◽  
Zhouwu Shu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Dna Methylation ◽  
Coronary Artery ◽  
Gene Dosage ◽  
Density Lipoprotein ◽  
Nucleotide Polymorphisms ◽  
Coronary Syndrome ◽  
Non Coding Rna ◽  
Artery Disease

Abstract Background Both DNA genotype and methylation of antisense non-coding RNA in the INK4 locus (ANRIL) have been robustly associated with coronary artery disease (CAD), but the interdependent mechanisms of genotype and methylation remain unclear. Methods Eighteen tag single nucleotide polymorphisms (SNPs) of ANRIL were genotyped in a matched case–control study (cases 503 and controls 503). DNA methylation of ANRIL and the INK4/ARF locus (p14ARF, p15INK4b and p16INK4a) was measured using pyrosequencing in the same set of samples (cases 100 and controls 100). Results Polymorphisms of ANRIL (rs1004638, rs1333048 and rs1333050) were significantly associated with CAD (p < 0.05). The incidence of CAD, multi-vessel disease, and modified Gensini scores demonstrated a strong, direct association with ANRIL gene dosage (p < 0.05). There was no significant association between ANRIL polymorphisms and myocardial infarction/acute coronary syndrome (MI/ACS) (p > 0.05). Methylation levels of ANRIL were similar between the two studied groups (p > 0.05), but were different in the rs1004638 genotype, with AA and AT genotype having a higher level of ANRIL methylation (pos4, p = 0.006; pos8, p = 0.019). Further Spearman analyses indicated that methylation levels of ANRIL were positively associated with systolic blood pressure (pos6, r = 0.248, p = 0.013), diastolic blood pressure (pos3, r = 0.213, p = 0.034; pos6, r = 0.220, p = 0.028), and triglyceride (pos4, r = 0.253, p = 0.013), and negatively associated with high-density lipoprotein cholesterol (pos2, r = − 0.243, p = 0.017). Additionally, we identified 12 transcription factor binding sites (TFBS) within the methylated ANRIL region, and functional annotation indicated these TFBS were associated with basal transcription. Methylation at the INK4/ARF locus was not associated with ANRIL genotype. Conclusions These results indicate that ANRIL genotype (tag SNPs rs1004638, rs1333048 and rs1333050) mainly affects coronary atherosclerosis, but not MI/ACS. There may be allele-related DNA methylation and allele-related binding of transcription factors within the ANRIL promoter.

scholarly journals Identification of a peripheral blood long non-coding RNA (Upperhand) as a potential diagnostic marker of coronary artery disease

2018 ◽  
Vol 25 (3) ◽  
pp. 393-402 ◽  
Author(s):  
Xuejie Li ◽  
Zhenzhou Zhao ◽  
Chuanyu Gao ◽  
Lixin Rao ◽  
Peiyuan Hao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Blood ◽  
Diagnostic Marker ◽  
Non Coding Rna ◽  
Artery Disease ◽  
Long Non Coding Rna

scholarly journals Relationship between long non-coding RNA polymorphism and the risk of coronary artery disease

Medicine ◽  
2021 ◽  
Vol 100 (12) ◽  
pp. e25146
Author(s):  
Bolin Wang ◽  
Zhihui Su ◽  
Lijun Wan ◽  
Tao He
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Non Coding Rna ◽  
Artery Disease ◽  
Long Non Coding Rna

The role of lnc-DC long non-coding RNA and SOCS1 in the regulation of STAT3 in coronary artery disease and type 2 diabetes mellitus

2018 ◽  
Vol 32 (3) ◽  
pp. 258-265 ◽  
Author(s):  
Asieh Alikhah ◽  
Majid Pahlevan Kakhki ◽  
Amirhossain Ahmadi ◽  
Reyhaneh Dehghanzad ◽  
Mohammad Ali Boroumand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Type 2 Diabetes Mellitus ◽  
Coronary Artery ◽  
Non Coding Rna ◽  
Artery Disease ◽  
Long Non Coding Rna

Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease

2015 ◽  
Vol 129 (8) ◽  
pp. 675-685 ◽  
Author(s):  
Yujia Yang ◽  
Yue Cai ◽  
Gengze Wu ◽  
Xinjian Chen ◽  
Yukai Liu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Non Coding Rna ◽  
Artery Disease ◽  
Long Non Coding Rna

In this paper we conclude that CoroMarker is a stable, sensitive and specific biomarker for CAD.

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