Comparative Efficacy and Safety of Antiulcer Drugs for Stress Ulcer Prophylaxis (SUP) in Critically Ill Patients: A Systematic Review and Network Meta-Analysis

2018 ◽  
Author(s):  
Pulin Yu ◽  
Hongliang Wang ◽  
Haitao Liu ◽  
Miao Liu ◽  
Guiyue Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Meta Analysis ◽  
Stress Ulcer Prophylaxis ◽  
Efficacy And Safety ◽  
Comparative Efficacy ◽  
Antiulcer Drugs ◽  
Ulcer Prophylaxis

scholarly journals Correction to: Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials

2017 ◽  
Vol 44 (2) ◽  
pp. 277-278 ◽  
Author(s):  
Waleed Alhazzani ◽  
Fayez Alshamsi ◽  
Emilie Belley-Cote ◽  
Diane Heels-Ansdell ◽  
Romina Brignardello-Petersen ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Randomized Trials ◽  
Stress Ulcer ◽  
Meta Analysis ◽  
Stress Ulcer Prophylaxis ◽  
Efficacy And Safety ◽  
Ulcer Prophylaxis

scholarly journals Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials

2017 ◽  
Vol 44 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Waleed Alhazzani ◽  
Fayez Alshamsi ◽  
Emilie Belley-Cote ◽  
Diane Heels-Ansdell ◽  
Romina Brignardello-Petersen ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Randomized Trials ◽  
Stress Ulcer ◽  
Meta Analysis ◽  
Stress Ulcer Prophylaxis ◽  
Efficacy And Safety ◽  
Ulcer Prophylaxis

Stress ulcer prophylaxis in the critically ill patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Saeed Mohamed Ibrahim ◽  
Sameh Salem Hefni Taha ◽  
Samuel Habachi Daniel ◽  
Emil Noshy Aziz Salh
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Meta Analysis ◽  
Stress Ulcer Prophylaxis ◽  
P Value ◽  
Gi Bleeding ◽  
Clinically Significant ◽  
Ulcer Prophylaxis

Abstract Background Sfress Ulceration was an important cause of morbidity and mortality in critically ill patients. Early active treatment reduces the risk of clinically significant bleeding, ulcer prophylaxis therefore became a standard of care in all critically ill patients. Objective The overall aims of the Stress ulcer prophylaxis in the critically ill patients is to determine the benefits and risks of stress ulcer prophylaxis stress ulcer prophylaxis (SUP) in intensive care unit Materials and Methods We performed this systematic review and meta-analysis according to the recommendations of the Meta-analysis of Observational Studies in Epidemiology (MOOSE) statement and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In the our systematic review and meta-analysis, we searched Medline via PubMed, CENTRAL, Web of Science, SCOPUS, and Google Scholar from March 1977 till August 2019. The search retrieved 2289 unique records. We then obtained 237 final results for full-text screening. At last, 28 recorded studies were involved in our in the present study. Results 23 included studies reported the rates of clinically important GI bleeding. The overall effect estimates favored SUP over control for decreasing the hazards of clinically significant GI hemorrhage (P value <0.001, OR— 0.55, CI of 95%[0.35 0.86]). The overall effect estimates did not favor SUP over control for reducing the rate of death (P value =0.24, OR 1.21, 95% CI [0.87 — 1.69]). 23 studies reported the rates of pneumonia. The overall effect estimates showed that the SUP was not related to elevated hazards of nosocomial pneumonia over control (P value —0.15, OR —1.5, CI of 95% [0.83 3.02]). The analysis showed that only Cimetidine 900 mg was effective in reducing the incidence of clinically important GI bleeding (OR 0.45 [0.24, 0.82], p *0.009). In contrary, none of the included PPIs (pantoprazole, lansoprazole, omeprazole), ranitidine, or sucralfate were effective in reducing the incidence of clinically important GI bleeding. Conclusion SUP is associated with lower risk of GI bleeding in critically ill patients; however, the current published literature shows significant inconsistency. Our analysis showed that, no significant difference between H2RA and PPI in term of incidence of clinically important GI bleeding, H2RAs (mainly cimetidine) more effective than other classes of SUP which significantly reduced the risk of overt GI hemorrhage, and none of the drug classes was effective in reducing the mortality rates.

Effect of Stress Ulcer Prophylaxis on Outcomes in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A345
Author(s):  
Diwas Shahi ◽  
Ajai Rajabalan ◽  
Jonathan Barrera-Calix ◽  
Sunil Paudel ◽  
Tamer Said Ahmed ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Meta Analysis ◽  
Stress Ulcer Prophylaxis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Ulcer Prophylaxis
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