Local Integrin Activation in Pancreatic Cells Targets Insulin Secretion to the Vasculature

2018 ◽  
Author(s):  
WannJun Gan ◽  
OanhhHoang Do ◽  
Louise Cottle ◽  
Elena Kosobrodova ◽  
Justin CooperrWhite ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Integrin Activation ◽  
Pancreatic Cells

scholarly journals Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic  -Cells

Diabetes ◽  
2005 ◽  
Vol 55 (1) ◽  
pp. 193-201 ◽  
Author(s):  
J. Yang ◽  
R. K. Wong ◽  
M. Park ◽  
J. Wu ◽  
J. R. Cook ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Atp Synthase ◽  
Pancreatic Cells

scholarly journals Fatty Acid Translocase (FAT/CD36) Is Localized on Insulin-Containing Granules in Human Pancreatic  -Cells and Mediates Fatty Acid Effects on Insulin Secretion

Diabetes ◽  
2005 ◽  
Vol 54 (2) ◽  
pp. 472-481 ◽  
Author(s):  
H. Noushmehr ◽  
E. D'Amico ◽  
L. Farilla ◽  
H. Hui ◽  
K. A. Wawrowsky ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Fatty Acid ◽  
Fatty Acid Translocase ◽  
Pancreatic Cells

scholarly journals Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

Diabetes ◽  
2008 ◽  
Vol 57 (6) ◽  
pp. 1618-1628 ◽  
Author(s):  
M. Braun ◽  
R. Ramracheya ◽  
M. Bengtsson ◽  
Q. Zhang ◽  
J. Karanauskaite ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Ion Channels ◽  
Voltage Gated ◽  
Pancreatic Cells ◽  
Electrophysiological Characterization ◽  
Voltage Gated Ion Channels ◽  
Gated Ion Channels

scholarly journals Long Term Sustained Growth of Insulin Producing Cells Using Agarose-Chitosan Coated Silver Nanocomposites

2021 ◽  
Vol 3 (1) ◽  
pp. 1-13
Author(s):  
Anasuya Ganguly ◽  
Keyword(s):  
Tissue Engineering ◽  
Insulin Secretion ◽  
Western Blotting ◽  
Extended Period ◽  
Transcript Level ◽  
Pancreatic Tissue ◽  
Isolated Population ◽  
Sustained Growth ◽  
Pancreatic Cells

Diabetes is a group of diseases characterized by high levels of blood sugar for an extended period. Despite newer and effective therapy, current treatment is riddled with fundamental challenges. To overcome the adverse effects of existing drugs, regenerative medicine has emerged as an essential treatment, for which tissue engineering may serve as a foundation for the repair of pancreatic cells secreting insulin. Different polymeric scaffolds have been explored for pancreatic tissue engineering. In the current study, a continuation of our preceding work we attempt to test the role of previously synthesized agarose-chitosan coated silver nanocomposite scaffold (AG-CHNp) for the long-term growth of pancreatic cells. Pancreatic cells were isolated from BALB/c mice and were characterized by dithizone (DTZ) staining, real time polymerase chain reaction (RT-PCR), western blotting, and flow cytometry for characteristic pancreatic markers. The isolated population of cells was grown on scaffolds and its effectiveness towards insulin secretion was studied. The isolated population was found to be positive for glucagon, PDX-1 and Pax-4, while a 200-fold change transcript level of insulin was observed. The cells upon seeding on the scaffolds exhibited sustained growth and insulin secretion as confirmed by western blotting. Overall, the study demonstrates the suitability and application of AG-CHNp for pancreatic tissue engineering.

Studies on insulin secretion by monolayer cultures of normal and tumorous human pancreatic cells. Effects of glucose, somatostatin and SMS 201–995

1987 ◽  
Vol 10 (6) ◽  
pp. 547-552 ◽  
Author(s):  
R. Oosterom ◽  
T. Verleun ◽  
P. Uitterlinden ◽  
H. A. Brunning ◽  
G. J. Bruining ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Cells ◽  
Monolayer Cultures

scholarly journals  -Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic   cells

2008 ◽  
Vol 105 (18) ◽  
pp. 6614-6619 ◽  
Author(s):  
N. Sonoda ◽  
T. Imamura ◽  
T. Yoshizaki ◽  
J. L. Babendure ◽  
J.-C. Lu ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Cells ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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