How Translational Medicine Is Progressively Redefining Healthcare: From Bench to Bedside, the Patient Is the Bedrock of Translational Research

2017 ◽  
Author(s):  
Fritz Dufour
Keyword(s):  
Translational Research ◽  
Translational Medicine

A decade of Science Translational Medicine

2019 ◽  
Vol 11 (489) ◽  
pp. eaax4327 ◽  
Author(s):  
Elazer R. Edelman ◽  
Garret A. FitzGerald
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Challenges And Opportunities

In this Editorial, co-Chief Scientific Advisors of Science Translational Medicine, Elazer Edelman and Garret FitzGerald, discuss challenges and opportunities for the next decade of translational research.

scholarly journals Establishment of research-oriented hospital: an important way for translational medicine development in China

2015 ◽  
Vol 87 (2) ◽  
pp. 1027-1032 ◽  
Author(s):  
MEINA LI ◽  
LULU ZHANG
Keyword(s):  
Translational Research ◽  
Development Strategy ◽  
Translational Medicine ◽  
Clinical Teaching ◽  
Core Competencies ◽  
Theoretical Research ◽  
Scientific Development ◽  
Medicine Development ◽  
Academic Exchange ◽  
The Times

Globally, one of the major trends is the development of translational medicine. The traditional hospital structure could not meet the demands of translational medicine development any longer and to explore a novel hospital structure is imperative. Following the times, China proposed and implemented a development strategy for a first-class modern research-oriented hospital. To establish a research-oriented hospital has become an important strategy to guide the scientific development of high-quality medical institutions and to advance translational medicine development. To facilitate translational medicine by developing research-oriented hospital, the Chinese Research Hospital Association (CRHA) has been established, which provides service of medicine, talents cultivation, scientific research and clinical teaching and covers areas of theoretical research, academic exchange, translational medicine, talents training and practice guiding. On the whole, research-oriented hospital facilitated translational medicine by developing interdisciplinary platform, training core competencies in clinical and translational research, providing financial support of translational research, and hosting journals on translational medicine, etc.

scholarly journals Artificial Intelligence in Translational Medicine

2021 ◽  
Vol 1 (3) ◽  
pp. 223-285
Author(s):  
Simone Brogi ◽  
Vincenzo Calderone
Keyword(s):  
Artificial Intelligence ◽  
Translational Research ◽  
Translational Medicine ◽  
Clinical Investigation ◽  
Scientific Data ◽  
Review Article ◽  
Computational Techniques ◽  
Computer Based ◽  
Gain Access ◽  
Applications Of Ai

The huge advancement in Internet web facilities as well as the progress in computing and algorithm development, along with current innovations regarding high-throughput techniques, enable the scientific community to gain access to biological datasets, clinical data and several databases containing billions of pieces of information concerning scientific knowledge. Consequently, during the last decade the system for managing, analyzing, processing and extrapolating information from scientific data has been considerably modified in several fields, including the medical one. As a consequence of the mentioned scenario, scientific vocabulary was enriched by novel lexicons such as machine learning (ML)/deep learning (DL) and overall artificial intelligence (AI). Beyond the terminology, these computational techniques are revolutionizing the scientific research in drug discovery pitch, from the preclinical studies to clinical investigation. Interestingly, between preclinical and clinical research, translational research is benefitting from computer-based approaches, transforming the design and execution of translational research, resulting in breakthroughs for advancing human health. Accordingly, in this review article, we analyze the most advanced applications of AI in translational medicine, providing an up-to-date outlook regarding this emerging field.

scholarly journals Artificial Intelligence in Translational Medicine

2021 ◽  
Author(s):  
Simone Brogi ◽  
Vincenzo Calderone
Keyword(s):  
Artificial Intelligence ◽  
Translational Research ◽  
Translational Medicine ◽  
Clinical Investigation ◽  
Scientific Data ◽  
Review Article ◽  
Computational Techniques ◽  
Computer Based ◽  
Gain Access ◽  
Applications Of Ai

The huge advancement of Internet web facilities as well as the progress in computing and algorithm development, along with current innovations regarding high-throughput techniques enables the scientific community to gain access to biological datasets, clinical data, and several databases containing billions of information concerning scientific knowledge. Consequently, during the last decade the system for managing, analyzing, processing and extrapolating information from scientific data has been considerably modified in several fields including the medical one. As a consequence of the mentioned scenario, scientific vocabulary was enriched by novel lexicons such as Machine Learning (ML)/Deep Learning (DL) and overall Artificial Intelligence (AI). Beyond the terminology, these computational techniques are revolutionizing the scientific research in drug discovery pitch, from the preclinical studies to clinical investigation. Interestingly, between preclinical and clinical research, the translational research is benefitting from computer-based approaches, transforming the design and execution of the translational research, resulting in breakthroughs for advancing human health. Accordingly, in this review article, we analyze the most advanced applications of AI in translational medicine, providing an up-to-date outlook regarding this emerging field.

scholarly journals Translational science in chronic tendinopathies

2021 ◽  
Vol 7 (3) ◽  
pp. 699
Author(s):  
Vijay J. Patel ◽  
Manish Khanna ◽  
Ketan K. Parmar
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Tendon Healing ◽  
Operative Management ◽  
Occupational Activity ◽  
Clinical Aspects ◽  
Complex Process ◽  
Medical Advance ◽  
Non Operative Management ◽  
Targeted Approach

<p>Chronic tendinopathies involve majority of patients in clinical practice of orthopaedic surgeons and sports physicians. Translational medicine confers an emerging medical advance efficiently towards the clinician directly from scientists which may be used as a targeted therapy. The main objective of translational research from “bench to bedside” is to test novel inventions in humans. Our purpose in this article to understand the translational medicine approach for chronic tendinopathies in clinical aspects. Translational research in chronic tendinopathies is required certainly due to plenty of reasons. Newer advances and targeted approach to these tendon disorders may curtail the further degenerative process. It aids in earlier diagnosis and prevention of morbidity, early occupancy of occupational activity, lack of economical as well as recreational failure. Pre-disease level activity is ultimate goal of any therapy. Tendon pathophysiology is constantly evolving researched topic in both biochemical as well as molecular aspect. The basic fundamental understanding of complex process of tendon healing and regeneration is necessary for formulating a newer guideline. The cornerstone of treatment of tendinopathies is still non-operative management. Physical therapy, better pain control, NSAIDS are still primary choice for these conditions. Various biological therapy whenever used one should combined them with other appropriate options to obtain an optimum outcome.</p>

scholarly journals Translational Science Research: Towards Better Health

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Emir Festic ◽  
Ognjen Gajic
Keyword(s):  
Clinical Research ◽  
Translational Research ◽  
Bosnia And Herzegovina ◽  
21St Century ◽  
Basic Science ◽  
Translational Medicine ◽  
Science Research ◽  
Research Centers ◽  
Research Knowledge ◽  
Basic Science Research

Even though it is considered a 21st century term, translational research has been present for much longer. Idea of translating experimental discovery to its’ clinical application and use is old as research itself. However, it is the understanding of missing links between the basic science research and clinical research that emerged in the past decade and mobilized scientific and clinical communities and organizations worldwide. Hence term, translational research, which represents an “enterprise of harnessing knowledge from basic sciences to produce new drugs, devices, and treatment options for patients” (1). It has been also characterized as “effective translation of the new knowledge, mechanisms, and techniques generated by advances in basic science research into new approaches for prevention, diagnosis, and treatment of disease, which is essential for improving health” (2).This translation is a complex process and involves more than one step for transfer of research knowledge. At least 3 such roadblocks have been identified (Figure 1) ; T1 translation: “The transfer of new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their first testing in humans”, T2 translation: “The translation of results from clinical studies into everyday clinical practice and health decision making”, and T3 translation: “Practice-based research, which is often necessary before distilled knowledge (e.g., systematic reviews, guidelines) can be implemented in practice” (3-5).The international research community rapidly recognized importance for promotion of translational research and made it their priority(5). In the USA, National Institutes of Health, (NIH) expects to fund 60 translational research centers with a budget of $500 million per year by 2012 (6). Besides academic centers, foundations, industry, disease-related organizations, and individual hospitals and health systems have also established translational research programs and at least 2 journals (Translational Medicine and the Journal of Translational Medicine) are devoted to the topic. In Europe, translational research has become a centerpiece of the European Commission’s €6 billion budget for health related research, and the United Kingdom has invested £450 million over 5 years to establish translational research centers (7).In this issue of Bosnian Journal of Basic Medical Sciences, members of medical section of Bosnian and Herzegovinian-American Academy of Arts and Sciences (BHAAAS), contributed their own work and expertise to bridge the gap between basic and clinical research, between inventing the treatments and getting them used in practice, and laid down foundations for future collaborative development of translational research in Bosnia and Herzegovina, as well as in the region (8).At the first glance of this issue’s table of content, a reader will easily notice the variety and breadth of topics and themes, from medical informatics and genetics, to hematology and oncology, pulmonary and critical care medicine, orthopedics, trauma surgery and neurosurgery. However, all of the articles share common ideas of translation of knowledge, from bench to bedside and back, and individualized approach to medicine, which are the true hallmarks of the 21st century medicine.Deeper under the surface and titles, there lies our common privilege and honor to be part of a broader mission of BHAAAS: to connect with our fellow physicians and scientists, and to build bridges of cooperation with our homeland, to promote the spirit of intellectual diversity and free exchange of ideas with the strong belief that this knowledge sharing will promote betterment of health in Bosnia and Herzegovina

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