Nudging for Corporate Long-Termism and Sustainability? Regulatory Instruments from a Comparative and Functional Perspective

2017 ◽  
Author(s):  
Florian MMslein ◽  
Karsten Engsig SSrensen
Keyword(s):  
Functional Perspective ◽  
Regulatory Instruments

Engaged Study of the Qur'an: Gauging its Effect on the Life of the Individual and of Society

2003 ◽  
Vol 5 (2) ◽  
pp. 202-207
Author(s):  
Ruqayya Ṭā Hā Jābir al-cUlwānī
Keyword(s):  
Social Conflict ◽  
Well Being ◽  
Arabic Language ◽  
Modern World ◽  
Educational Systems ◽  
Functional Perspective ◽  
Number Of Factors ◽  
Social Advancement ◽  
Freedom Of Thought ◽  
The Individual

An engaged and perceptive contemplation of the Qur'an forms one of the most important bases for the cultural and social advancement of Muslims in all walks of life, and the absence of such study is one of the reasons behind the general cultural attenuation in the modern world. Reflection is one of the means of the construction and formation of a civilised society. The applied faculty of intellect creates an environment which allows reflective and considered thought to be developed from a functional perspective for the general well-being of society. Meanwhile the effective neglect of such study leads to the proliferation of superstition, dissent and social conflict. Indeed it can even be argued that it diminishes the significance of the laws and conventions which serve as the backbone of society. This paper reveals a number of factors which can impede the achievement of such an engaged study of the text: thus, for instance, thoughtless obedience to societal conventions; shortcomings in educational systems and syllabi; and a failure to encompass the significance of the Arabic language. Furthermore this paper presents several effective suggestions for nurturing students' potential, encouraging an environment which allows freedom of thought, and its refinement.

Closing the gap: an atomistic structural and functional perspective of S. mansoni universal stress G4LZI3 protein in complex with phenolic compounds

2020 ◽  
Vol 17 ◽  
Author(s):  
Priscilla Masamba ◽  
Geraldene Munsamy ◽  
Abidemi Paul Kappo
Keyword(s):  
Phenolic Compounds ◽  
Conformational Changes ◽  
Stress Protein ◽  
Md Simulations ◽  
Binding Energies ◽  
Developmental Cycle ◽  
Structure Based Drug Design ◽  
Bioinformatic Tools ◽  
Drug Of Choice ◽  
Functional Perspective

Background: For decades, Praziquantel has been the undisputed drug of choice for all schistosome infections, but rising concerns due to the unelucidated mechanism of action of the drug and unavoidable reports of emerging drug resistant strains has necessitated the need for alternative treatment drug. Moreover, current apprehension has been reinforced by total dependence on the drug for treatment hence, the search for novel and effective anti-schistosomal drugs. Uses: This study made use of bioinformatic tools to determine the structural binding of the Universal G4LZI3 stress protein (USP) in complex with ten polyphenol compounds, thereby highlighting the effectiveness of these recently identified ‘lead’ molecules in the design of novel therapeutics targeted against schistosomiasis. Upregulation of the G4LZI3 USP throughout the schistosome multifaceted developmental cycle sparks interest in its potential role as a druggable target. The integration of in silico tools provides an atomistic perspective into the binding of potential inhibitors to target proteins. Conclusion: This study therefore, implemented the use of molecular dynamic (MD) simulations to provide functional and structural insight into key conformational changes upon binding of G4ZLI3 to these key phenolic compounds. Post-MD analyses revealed unique structural and conformational changes in the G4LZI3 protein in complex with curcumin and catechin respectively. These systems exhibited the highest binding energies, while the major interacting residues conserved in all the complexes provides a route map for structure-based drug design of novel compounds with enhanced inhibitory potency against the G4LZI3 protein. This study suggests an alternative approach for the development of anti-schistosomal drugs using natural compounds.

The Russian Sharped Geminate Palatals in Functional Perspective

1982 ◽  
Vol 6 (2) ◽  
pp. 277-291
Author(s):  
Michael S. Flier
Keyword(s):  
Functional Perspective

scholarly journals Understanding Water Use Conflicts to Advance Collaborative Planning: Lessons Learned from Lake Diefenbaker, Canada

Water ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 1756
Author(s):  
Jania Chilima ◽  
Jill Blakley ◽  
Harry Diaz ◽  
Lalita Bharadwaj
Keyword(s):  
Water Use ◽  
Flood Control ◽  
Collaborative Planning ◽  
Lessons Learned ◽  
Canadian Prairie ◽  
Water Users ◽  
Management Procedures ◽  
Lake Diefenbaker ◽  
Regulatory Instruments ◽  
Water Uses

Conflicts around the multi-purpose water uses of Lake Diefenbaker (LD) in Saskatchewan, Canada need to be addressed to meet rapidly expanding water demands in the arid Canadian prairie region. This study explores these conflicts to advance collaborative planning as a means for improving the current water governance and management of this lake. Qualitative methodology that employed a wide participatory approach was used to collect focus group data from 92 individuals, who formed a community of water users. Results indicate that the community of water users is unified in wanting to maintain water quality and quantity, preserving the lake’s aesthetics, and reducing water source vulnerability. Results also show these users are faced with water resource conflicts resulting from lack of coherence of regulatory instruments in the current governance regime, and acceptable management procedures of both consumptive and contemporary water uses that are interlinked in seven areas of: irrigation, industrial, and recreational water uses; reservoir water level for flood control and hydroelectricity production; wastewater and lagoon management; fish farm operations; and regional water development projects. As a means of advancing collaborative planning, improvements in water allocation and regulatory instruments could be made to dissipate consumptive use conflicts and fill the under-regulation void that exists for contemporary water uses. Additionally, a comprehensive LD water use master plan, as a shared vision to improve participation in governance, could be developed to direct the water uses that have emerged over time. This study suggests that these three areas are practical starting conditions that would enable successful collaborative planning for the seven areas of water uses. Focusing on these three areas would ensure the current and future needs of the community of water users are met, while avoiding reactive ways of solving water problems in the LD region, especially as the water crisis in the Canadian Prairie region where LD is located is expected to intensify.

Recognition and zoning optimization of geographical spatial conflict in Wuhan metropolitan area based on multi-functional perspective

2020 ◽  
pp. 002072092098354
Author(s):  
Junfeng Zhang ◽  
Jinyuan Tao ◽  
Lei Xu ◽  
Xiong Zhang ◽  
Yuteng Sun
Keyword(s):  
Metropolitan Area ◽  
Agricultural Production ◽  
Dabie Mountains ◽  
Jianghan Plain ◽  
Functional Perspective ◽  
Urban Construction ◽  
Ecological Protection ◽  
Conflict Zone ◽  
Wuhan Metropolitan Area ◽  
Geographical Space

Identifying geographical spatial conflicts and optimizing development patterns are important prerequisites for eliminating the conflicts of geographical spatial conflict. The paper takes the Wuhan Metropolitan Area as an example. Using grid-scale data, we construct a multi-functional suitability evaluation index system for geographical space, starting from three dimensions: ecological protection, agricultural production and urban construction. The multi-index comprehensive evaluation method is used to measure the geographical spatial suitability level and identify the characteristics of geographical spatial conflict patterns. Three-dimensional Rubik's cube model is used to divide the space conflict types and optimize the partition. We found that the areas with suitable ecological protection functions and more suitable areas are mainly distributed near the waters and the Dabie Mountains and Mufu Mountains with relatively high altitude in Wuhan Metropolitan Area. Suitable areas for agricultural production functions are concentrated in the Jianghan Plain. Suitable areas for urban construction functions are concentrated around urban areas, established towns, and major transportation routes. Regions with high intensity of land and space conflicts are mainly located in the central and northwestern parts of the Wuhan Metropolitan Area. Regions with low levels of conflict are concentrated in the west, northeast, and southeast regions of the Wuhan Metropolitan Area. The degree of geographical spatial conflict in Wuhan Metropolitan Area can be divided into three primary zones and 12 secondary zones, which are intense conflict zone, general conflict zone, and weak conflict zone. Based on multi-functional perspective, identifying and analyzing the types of geographical spatial conflict will help locate the development direction of different conflict areas and provide theoretical and technical support for the optimization of geographical space.

scholarly journals Identification of Novel Mutations in Colorectal Cancer Patients Using AmpliSeq Comprehensive Cancer Panel

2021 ◽  
Vol 11 (6) ◽  
pp. 535
Author(s):  
Bader Almuzzaini ◽  
Jahad Alghamdi ◽  
Alhanouf Alomani ◽  
Saleh AlGhamdi ◽  
Abdullah A. Alsharm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Cancer Patients ◽  
Biomarker Discovery ◽  
Local Population ◽  
Network Analyses ◽  
Functional Perspective ◽  
Novel Variants ◽  
Colorectal Cancer Patients ◽  
Cancer Panel

Biomarker discovery would be an important tool in advancing and utilizing the concept of precision and personalized medicine in the clinic. Discovery of novel variants in local population provides confident targets for developing biomarkers for personalized medicine. We identified the need to generate high-quality sequencing data from local colorectal cancer patients and understand the pattern of occurrence of variants. In this report, we used archived samples from Saudi Arabia and used the AmpliSeq comprehensive cancer panel to identify novel somatic variants. We report a comprehensive analysis of next-generation sequencing results with a coverage of >300X. We identified 466 novel variants which were previously unreported in COSMIC and ICGC databases. We analyzed the genes associated with these variants in terms of their frequency of occurrence, probable pathogenicity, and clinicopathological features. Among pathogenic somatic variants, 174 were identified for the first time in the large intestine. APC, RET, and EGFR genes were most frequently mutated. A higher number of variants were identified in the left colon. Occurrence of variants in ERBB2 was significantly correlated with those of EGFR and ATR genes. Network analyses of the identified genes provide functional perspective of the identified genes and suggest affected pathways and probable biomarker candidates. This report lays the ground work for biomarker discovery and identification of driver gene mutations in local population.

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