Network Formation and Financial Fragility

SSRN Electronic Journal ◽

10.2139/ssrn.2480767 ◽

2014 ◽

Author(s):

Danilo Lopomo Beteto Wegner

Keyword(s):

Network Formation ◽

Financial Fragility

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Platelet Microtubules in Clot Structure Formation and Contractile Force Generation: Investigation of a Controversy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661596 ◽

1986 ◽

Vol 56 (01) ◽

pp. 023-027 ◽

Cited By ~ 9

Author(s):

C J Jen ◽

L V McIntire

Keyword(s):

Network Formation ◽

Contractile Force ◽

Second Phase ◽

Clot Retraction ◽

Forming Process ◽

Microtubule Organization ◽

Physiological Processes ◽

Fibrin Network ◽

Two Parameters

SummaryWhether platelet microtubules are involved in clot retraction/ contraction has been controversial. To address this question we have simultaneously measured two clotting parameters, clot structural rigidity and isometric contractile force, using a rheological technique. For recalcified PRP clots these two parameters began rising together at about 15 min after CaCl2 addition. In the concentration range affecting microtubule organization in platelets, colchicine, vinca alkaloids and taxol demonstrated insignificant effects on both clotting parameters of a recalcified PRP clot. For PRP clots induced by adding small amounts of exogenous thrombin, the kinetic curves of clot rigidity were biphasic and without a lag time. The first phase corresponded to a platelet-independent network forming process, while the second phase corresponded to a platelet-dependent process. These PRP clots began generating contractile force at the onset of the second phase. For both rigidity and force parameters, only the second phase of clotting kinetics was retarded by microtubule affecting reagents. When PRP samples were clotted by adding a mixture of CaCl2 and thrombin, the second phase clotting was accelerated and became superimposed on the first phase. The inhibitory effects of micro tubule affecting reagents became less pronounced. Thrombin clotting of a two-component system (washed platelets/ purified fibrinogen) was also biphasic, with the second phase being microtubule-dependent. In conclusion, platelet microtubules are important in PRP clotted with low concentrations of thrombin, during which fibrin network formation precedes platelet-fibrin interactions. On the other hand they are unimportant if a PRP clot is induced by recalcification, during which the fibrin network is constructed in the presence of platelet-fibrin interactions. The latter is likely to be more analogous to physiological processes in vivo.

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Post-Keynesian Macroeconomics: Basic Perspectives

Voprosy Ekonomiki ◽

10.32609/0042-8736-2006-5-19-31 ◽

2006 ◽

pp. 19-31 ◽

Cited By ~ 6

Author(s):

I. Rozmainsky

Keyword(s):

Economic Policy ◽

Endogenous Growth ◽

Financial Fragility ◽

Russian Economy ◽

Endogenous Money

The paper considers basic perspectives of post-Keynesian macroeconomics. The author describes post-Keynesian views on theories of durables choice, endogenous money, financial fragility, hysteresis, conflict inflation and endogenous growth. The paper shows distinctions of post-Keynesian approach from both neoclassical tradition and other branches of Keynesianism. The author examines links between post-Keynesian macroeconomics and macroeconomics of Keynes. The paper also considers post-Keynesian views on economic policy and analyzes the relevance of post-Keynesian approach for the post-Soviet Russian economy.

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