Teaching the Biological Clock: Age-Related Fertility Decline and Sex Education

2014 ◽  
Author(s):  
Kerry L. Macintosh
Keyword(s):  
Sex Education ◽  
Fertility Decline ◽  
Biological Clock ◽  
Age Related

The Biological Clock and Sleep in the Elderly

2006 ◽  
Vol 19 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Myriam Juda ◽  
Mirjam Münch ◽  
Anna Wirz-Justice ◽  
Martha Merrow ◽  
Till Roenneberg
Keyword(s):  
Circadian Rhythms ◽  
Biological Clock ◽  
The Elderly ◽  
Early Morning ◽  
Behavioral Changes ◽  
Older Age ◽  
Age Related ◽  
Theoretical Considerations ◽  
Sleep Difficulties ◽  
Circadian Biology

Abstract: Among many other changes, older age is characterized by advanced sleep-wake cycles, changes in the amplitude of various circadian rhythms, as well as reduced entrainment to zeitgebers. These features reveal themselves through early morning awakenings, sleep difficulties at night, and a re-emergence of daytime napping. This review summarizes the observations concerning the biological clock and sleep in the elderly and discusses the documented and theoretical considerations behind these age-related behavioral changes, especially with respect to circadian biology.

scholarly journals TERRA: A Novel Biomarker of Embryo Quality and Art Outcome

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 475
Author(s):  
Maria Santa Rocca ◽  
Ludovica Dusi ◽  
Andrea Di Nisio ◽  
Erminia Alviggi ◽  
Benedetta Iussig ◽  
...  
Keyword(s):  
Telomere Length ◽  
Dna Sequences ◽  
Male Fertility ◽  
Embryo Quality ◽  
Assisted Reproductive Technologies ◽  
Biological Clock ◽  
Reproductive Technologies ◽  
Age Related ◽  
Non Coding Rna ◽  
First Time

Telomeres are considered to be an internal biological clock, and their progressive shortening has been associated with the risk of age-related diseases and reproductive alterations. Over recent years, an increasing number of studies have focused on the association between telomere length and fertility, identifying sperm telomere length (STL) as a novel biomarker of male fertility. Although typically considered to be repeated DNA sequences, telomeres have recently been shown to also include a long non-coding RNA (lncRNA) known as TERRA (telomeric repeat-containing RNAs). Interestingly, males with idiopathic infertility show reduced testicular TERRA expression, suggesting a link between TERRA and male fertility. The aim of this study was to investigate the role of seminal TERRA expression in embryo quality. To this end, STL and TERRA expression were quantified by Real Time qPCR in the semen of 35 men who underwent assisted reproductive technologies (ART) and 30 fertile men. We found that TERRA expression in semen and STL was reduced in patients that underwent ART (both p < 0.001). Interestingly, TERRA and STL expressions were positively correlated (p = 0.010), and TERRA expression was positively associated with embryo quality (p < 0.001). These preliminary findings suggest a role for TERRA in the maintenance of sperm telomere integrity during gametogenesis, and for the first time, TERRA expression was found as a predictive factor for embryo quality in the setting of assisted reproduction.

scholarly journals Knowing and Not Knowing about Fertility: Childless Women and Age-Related Fertility Decline

2021 ◽  
Vol 42 (1) ◽  
pp. 30-48
Author(s):  
Lauren Jade Martin
Keyword(s):  
Fertility Decline ◽  
Formal Education ◽  
Structured Interviews ◽  
Multiple Sources ◽  
Childless Women ◽  
Age Related ◽  
Reproductive Decision Making ◽  
Biomedical Diagnostics ◽  
Individual Self ◽  
Knowledge Claims

Knowledge claims may play an essential role in reproductive decision-making, as individuals seek out, assess, reject, and use information about health and fertility gathered from numerous sources. This paper focuses specifically on childless women’s self-perceptions of knowledge about infertility and age-related fertility decline. How knowledgeable do childless women perceive themselves to be about fertility and infertility in general, and from where they do they obtain this knowledge? Furthermore, how knowledgeable do childless women perceive themselves to be about their own fertility and ability to conceive, and to what do they attribute this knowledge? Data for this project was gathered through semi-structured interviews with 72 childless American women; the interviews were inductively and thematically coded using qualitative-analysis software. Childless women assessed their general knowledge of fertility as confident, self-doubting, or novices, and they claimed multiple sources as the basis of this knowledge, including formal education and training, media and popular culture, and family members and peers. When assessing knowledge about their own fecundity, the women tended to rely on two additional sources: biomedical diagnostics and embodied knowledge. Childless women’s awareness of average statistics of age-related fertility decline did not necessarily translate to individual self-knowledge about their own bodies and fecundity. Because knowledge claims were based on multiple information sources given unequal weight, this raises questions about authoritative knowledge—that is, the knowledge that “counts” for women as they make decisions regarding their future childbearing.

scholarly journals Women's intentions to use fertility preservation to prevent age-related fertility decline

2016 ◽  
Vol 32 (1) ◽  
pp. 121-131 ◽  
Author(s):  
Anne ter Keurst ◽  
Jacky Boivin ◽  
Sofia Gameiro
Keyword(s):  
Fertility Preservation ◽  
Fertility Decline ◽  
Age Related

Is vitrification of oocytes useful for fertility preservation for age-related fertility decline and in cancer patients?

2013 ◽  
Vol 99 (6) ◽  
pp. 1485-1495 ◽  
Author(s):  
Ana Cobo ◽  
Juan A. Garcia-Velasco ◽  
Javier Domingo ◽  
José Remohí ◽  
Antonio Pellicer
Keyword(s):  
Cancer Patients ◽  
Fertility Preservation ◽  
Fertility Decline ◽  
Age Related

Abstract MP88: Fetuin-A, a Vascular Biomarker of Cognitive Decline in Older Adults

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Gail A Laughlin ◽  
Linda K McEvoy ◽  
Elizabeth Barrett-Connor ◽  
Lori B Daniels ◽  
Joachim H Ix
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Vascular Disease ◽  
Sex Education ◽  
Cognitive Aging ◽  
Community Dwelling ◽  
Fetuin A ◽  
High Functioning ◽  
Age Related

Objectives: The contribution of vascular disease to neurocognitive decline is now widely recognized. Fetuin-A is an abundant plasma protein known to predict vascular disease. Prior studies have shown that fetuin-A levels are lower in patients with Alzheimer’s disease in direct proportion to the severity of cognitive impairment; however, their association with normal cognitive aging is unknown. We evaluated the association of serum fetuin-A levels with cognitive function in relatively high-functioning, community-dwelling older adults from the Rancho Bernardo Study. Methods: This is a population-based study of 1382 older adults (median age 75) who had plasma fetuin-A levels and cognitive function evaluated in 1992-96; 855 had repeat cognitive function assessment a median of 4 years later. Results: Adjusting for age, sex, education, and depression, higher levels of fetuin-A were associated with better baseline performance on the Mini-Mental Status Exam (MMSE) (P=0.012) and a tendency for better Trails Making B scores (P=0.066). In longitudinal analyses, the likelihood of a major decline (highest decile of change) in Trails B was 29% lower (P=0.010) for each SD higher baseline fetuin-A level; odds of major decline in MMSE was 42% lower (P=0.005) per SD higher fetuin-A for individuals with no known CVD, but were not related to fetuin-A in those with CVD (P=0.33). Fetuin-A was not related to Category Fluency performance. Results did not vary by sex and were not explained by numerous vascular risk factors and comorbidities. Conclusions: Higher plasma fetuin-A concentrations are associated with better performance on tests of global cognitive function and executive function and with reduced likelihood of major decline in these cognitive abilities over a 4-year period. These observations are consistent with the hypothesis that higher fetuin-A protects against cognitive decline in relatively high functioning older adults, although this may be less apparent in those with established vascular disease. Fetuin-A may serve as a biological link between vascular disease and normal age-related cognitive decline.

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