The Sleep-Wake Cycle and Circadian Rhythm Disruption: Shift Work and Cardiovascular Disease Risk

2012 ◽  
Author(s):  
Peter Ciechanowski
Keyword(s):  
Cardiovascular Disease ◽  
Circadian Rhythm ◽  
Shift Work ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

Association of shift work with cardiovascular disease risk among Chinese workers

2021 ◽  
pp. 1-9
Author(s):  
Xiaobing Feng ◽  
Weihong Qiu ◽  
Man Cheng ◽  
Ruyi Liang ◽  
Tao Xu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Shift Work ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Chinese Workers

scholarly journals Circadian misalignment increases cardiovascular disease risk factors in humans

2016 ◽  
Vol 113 (10) ◽  
pp. E1402-E1411 ◽  
Author(s):  
Christopher J. Morris ◽  
Taylor E. Purvis ◽  
Kun Hu ◽  
Frank A. J. L. Scheer
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Shift Work ◽  
Disease Risk ◽  
Excretion Rate ◽  
Cardiovascular Disease Risk ◽  
Circadian Misalignment ◽  
Increased Risk ◽  
The Impact

Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in humans. Here we show—by using two 8-d laboratory protocols—that short-term circadian misalignment (12-h inverted behavioral and environmental cycles for three days) adversely affects cardiovascular risk factors in healthy adults. Circadian misalignment increased 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 3.0 mmHg and 1.5 mmHg, respectively. These results were primarily explained by an increase in blood pressure during sleep opportunities (SBP, +5.6 mmHg; DBP, +1.9 mmHg) and, to a lesser extent, by raised blood pressure during wake periods (SBP, +1.6 mmHg; DBP, +1.4 mmHg). Circadian misalignment decreased wake cardiac vagal modulation by 8–15%, as determined by heart rate variability analysis, and decreased 24-h urinary epinephrine excretion rate by 7%, without a significant effect on 24-h urinary norepinephrine excretion rate. Circadian misalignment increased 24-h serum interleukin-6, C-reactive protein, resistin, and tumor necrosis factor-α levels by 3–29%. We demonstrate that circadian misalignment per se increases blood pressure and inflammatory markers. Our findings may help explain why shift work increases hypertension, inflammation, and cardiovascular disease risk.

scholarly journals Prevalent cardiovascular disease, risk factors and selection out of shift work

2006 ◽  
Vol 32 (3) ◽  
pp. 204-208 ◽  
Author(s):  
Mika Kivimäki ◽  
Marianna Virtanen ◽  
Marko Elovainio ◽  
Ari Väänänen ◽  
Liisa Keltikangas-Järvinen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Shift Work ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors

Shift work and risk of cardiovascular disease morbidity and mortality: A dose–response meta-analysis of cohort studies

2018 ◽  
Vol 25 (12) ◽  
pp. 1293-1302 ◽  
Author(s):  
Dongming Wang ◽  
Wenyu Ruan ◽  
Zhenlong Chen ◽  
Ying Peng ◽  
Wenzhen Li
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Shift Work ◽  
Dose Response ◽  
Disease Risk ◽  
Meta Analysis ◽  
Cardiovascular Disease Risk ◽  
Morbidity And Mortality ◽  
Prospective Cohort Studies ◽  
Disease Mortality

Background Previous studies have suggested that shift work is associated with a higher risk of cardiovascular disease. However, the quantitative dose–response relationship between duration of shift work and cardiovascular disease risk is still unknown. We aimed to evaluate the dose–response association between duration of shift work and risk of cardiovascular disease morbidity and mortality. Design A systematic review and meta-analysis. Methods PubMed and Embase were searched from inception to 1 December 2017. Prospective cohort studies that reported the associations between duration of shift work and cardiovascular disease risk with at least three categories were included. Data were pooled by using fixed or random effect models. The continuous dose–response associations were assessed by using fixed effect restricted cubic splines with four knots. Results Five prospective cohort studies with 10 reports were included. No evidence of a curvilinear association was observed between duration of shift work and risk of cardiovascular disease, similar findings were observed in cardiovascular disease morbidity and mortality. The summary relative risk (RR) of an increase of 5 years of shift work was 1.05 (1.04–1.07) with moderate heterogeneity ( P = 0.142, I2 = 33.2%) for cardiovascular disease, 1.06 (1.04–1.08) with low heterogeneity ( P = 0.279, I2 = 21.7%) for cardiovascular disease morbidity, and 1.04 (1.02–1.06) with moderate heterogeneity ( P = 0.135, I2 = 38.5%) for cardiovascular disease mortality, respectively. Conclusions Shift work could probably increase the risk of cardiovascular disease and cardiovascular disease mortality in a dose–response way. These findings could have implications for guideline recommendations regarding the risk related to shift schedules.

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