Coefficients of Structural Association

2012 ◽  
Author(s):  
Stan Lipovetsky ◽  
Igor Mandel
Keyword(s):  
Structural Association

Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview

2019 ◽  
Vol 23 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Qiang Zhang ◽  
Xude Wang ◽  
Liyan Lv ◽  
Guangyue Su ◽  
Yuqing Zhao
Keyword(s):  
Structural Modification ◽  
Gastrointestinal Disease ◽  
Structure Activity Relationship ◽  
Cerebrovascular Diseases ◽  
Activity Relationship ◽  
Cycle Arrest ◽  
Structure Activity ◽  
Wide Range ◽  
Structural Association ◽  
Relationship Of

Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease and other conditions. In order to develop new antineoplastic drugs, it is necessary to improve the bioactivity, solubility and bioavailability, and illuminate the mechanism of action of these compounds. A large number of ginsenosides and their derivatives have been separated from certain herbs or synthesized, and tested in various experiments, such as anti-proliferation, induction of apoptosis, cell cycle arrest and cancer-involved signaling pathways. In this review, we have summarized the progress in structural modification, shed light on the structure-activity relationship (SAR), and offered insights into biosynthesis-structural association. This review is expected to provide a preliminary guide for the modification and synthesis of ginsenosides.

Metabolic Compartmentation in Living Cells: Structural Association of Aldolase

1997 ◽  
Vol 237 (2) ◽  
pp. 445-451 ◽  
Author(s):  
Jian Wang ◽  
Dean R. Tolan ◽  
Len Pagliaro
Keyword(s):  
Living Cells ◽  
Metabolic Compartmentation ◽  
Structural Association

scholarly journals Structural Symmetry of DNA Nucleotides and Steroid Hormones

2020 ◽  
Author(s):  
Charles Schaper
Keyword(s):  
Structural Analysis ◽  
Steroid Hormones ◽  
Functional Group ◽  
Structural Characteristics ◽  
Base Pairs ◽  
Detailed Structural Analysis ◽  
Structural Association ◽  
Direct Binding ◽  
Structural Correspondence ◽  
Oxygen Group

DNA is comprised of important structural characteristics, which include the complementary base pairs of adenine-thymine (A-T) and cytosine-guanine (C-G) that serve to initiate and code for transcription and translation into amino acids. Recently, structural analysis of DNA performed in this lab indicated that each DNA nucleotide complementary base pair is in perfect correspondence with the structure of the steroid molecule and steroid hormones. Here, detailed structural analysis and illustrations are presented to clearly support and extend this fundamental finding. The structural illustrations indicate that the DNA Nucleotide base pairs can achieve perfect alignment with steroid hormones, such that each of its functional groups can be assigned a purpose for binding, stabilization, and transcription regulation. The relation of the missing third hydrogen bond for A-T and T-A, relative to the three hydrogen bonds of C-G and G-C, is clearly shown to be found through its coupling with the class of corticosteroids like cortisol that have an oxygen group perfectly positioned for interaction with the available functional group of thymine. Thus the intermolecular coupling by hydrogen bonding of Cortisol-Thymine produces a strong complex. Moreover, the structural analysis of the end group couplings to an ionic linkage element, Ca2+ or Mg2+, demonstrate interaction with both the DNA phosphates as well as the oxygen element within the sugar. The relationships confirm a structural association of cortisol-like steroid hormones with A-T and T-A and a structural association of testosterone-like steroid hormones for G-C and C-G. Synthetic steroids are assessed, including prednisolone and dexamethasone, to indicate consistency of the functional group interactions with the DNA base pairs, phosphate, and sugar groups to support and confirm direct binding and structural correspondence of steroid hormones to DNA Nucleotides.

scholarly journals Structural Symmetry of DNA Nucleotides and Steroid Hormones

2020 ◽  
Author(s):  
Charles Schaper
Keyword(s):  
Structural Analysis ◽  
Steroid Hormones ◽  
Functional Group ◽  
Structural Characteristics ◽  
Base Pairs ◽  
Detailed Structural Analysis ◽  
Structural Association ◽  
Direct Binding ◽  
Structural Correspondence ◽  
Oxygen Group

DNA is comprised of important structural characteristics, which include the complementary base pairs of adenine-thymine (A-T) and cytosine-guanine (C-G) that serve to initiate and code for transcription and translation into amino acids. Recently, structural analysis of DNA performed in this lab indicated that each DNA nucleotide complementary base pair is in perfect correspondence with the structure of the steroid molecule and steroid hormones. Here, detailed structural analysis and illustrations are presented to clearly support and extend this fundamental finding. The structural illustrations indicate that the DNA Nucleotide base pairs can achieve perfect alignment with steroid hormones, such that each of its functional groups can be assigned a purpose for binding, stabilization, and transcription regulation. The relation of the missing third hydrogen bond for A-T and T-A, relative to the three hydrogen bonds of C-G and G-C, is clearly shown to be found through its coupling with the class of corticosteroids like cortisol that have an oxygen group perfectly positioned for interaction with the available functional group of thymine. Thus the intermolecular coupling by hydrogen bonding of Cortisol-Thymine produces a strong complex. Moreover, the structural analysis of the end group couplings to an ionic linkage element, Ca2+ or Mg2+, demonstrate interaction with both the DNA phosphates as well as the oxygen element within the sugar. The relationships confirm a structural association of cortisol-like steroid hormones with A-T and T-A and a structural association of testosterone-like steroid hormones for G-C and C-G. Synthetic steroids are assessed, including prednisolone and dexamethasone, to indicate consistency of the functional group interactions with the DNA base pairs, phosphate, and sugar groups to support and confirm direct binding and structural correspondence of steroid hormones to DNA Nucleotides.

Forming Coalitions: A Network-Theoretic Approach to the Contemporary South Korean Environmental Movement

2008 ◽  
Vol 13 (1) ◽  
pp. 99-114 ◽  
Author(s):  
Hyung Park
Keyword(s):  
Collective Action ◽  
Coalition Formation ◽  
Environmental Movement ◽  
Theoretic Approach ◽  
Religiously Affiliated ◽  
South Korean ◽  
Structural Association ◽  
Movement Organizations ◽  
Environmental Network

This article investigates how multiple movement structures interplayed with each other in collective action/social movements in South Korea over the period, 2003-2004. By employing advanced methods in social network analysis, meta-network representation, analysis of structural association, and analysis of structural sequence, this article aims to complement existing paradigms of social movement research. Specifically, it investigates the forces that led environmental movement organizations (EMOs) to form coalitions based on the structured relations between governing personnel, movement ideologies and coalitions. The findings suggest that sharing similar ideologies facilitated coalition formation among EMOs and the role of coordination between governing personnel across the EMOs was marginal. Furthermore, a few leading EMOs were central actors across different movement structures, though religiously affiliated Green Christ and Catholic Environmental Network were also active in coalition formation. The framework and the findings further scholarship on collective action among organizations of varying forms (e.g., firms, unions) in the environ-mental movement sector and in other societal settings as well.

Geological Characterization of the Idalia Hill Fault Zone and Its Structural Association with the Commerce Geophysical Lineament, Idalia, Missouri

2006 ◽  
Vol 96 (6) ◽  
pp. 2281-2303 ◽  
Author(s):  
J. N. Baldwin ◽  
R. C. Witter ◽  
J. D. Vaughn ◽  
J. B. Harris ◽  
J. L. Sexton ◽  
...  
Keyword(s):  
Fault Zone ◽  
Structural Association

Type VI collagen forms a structural association with hyaluronan in vivo

1991 ◽  
Vol 19 (4) ◽  
pp. 384S-384S ◽  
Author(s):  
CAY M. KIELTY ◽  
STEPHEN P. WHITTAKER ◽  
MICHAEL E. GRANT ◽  
C. ADRIAN SHUTTLEWORTH
Keyword(s):  
Type Vi Collagen ◽  
Structural Association

scholarly journals Study on the residual lignin in Eucalyptus globulus sulphite pulp

Holzforschung ◽  
2015 ◽  
Vol 69 (5) ◽  
pp. 513-522 ◽  
Author(s):  
Sandra Magina ◽  
Ana P. Marques ◽  
Dmitry V. Evtuguin
Keyword(s):  
Eucalyptus Globulus ◽  
Structural Features ◽  
Kraft Pulps ◽  
Residual Lignin ◽  
Benzylic Carbon ◽  
Structural Peculiarities ◽  
Structural Association ◽  
Nmr Techniques ◽  
Degree Of Condensation ◽  
Spent Liquor

Abstract The residual lignin (LR sample) was isolated from unbleached acid sulphite pulp from Eucalyptus globulus with kappa number 18.2 by acidolysis and structurally characterized by wet chemistry and NMR techniques. The main structural features of LR were compared with lignin isolated from sulphite spent liquor (LSSL sample) and dioxane lignin (DL sample) from eucalypt wood. LR contains less sulphonic groups (4.4%) compared to LSSL (11.3%), and its molecular weight (2200 Da) is very close to that of DL (2600 Da). A part of sulphonic groups is located at the benzylic carbon in β-O-4′ and β-5′ structures. LR revealed ca. 20% lower abundance of β-O-4′ structures than DL, but ca. 40% higher abundance of these structures than LSSL. The degree of condensation of LR was higher than that of DL but lower than that of LSSL. The condensed structures in LR mainly originate from C6-linked syringyl units. The structural peculiarities of LR consisted of the relatively high proportion of syringyl units compared to DL and the strong structural association with hemicelluloses via benzyl ether linkages. The differences in the structure of residual lignins from eucalypt sulphite and kraft pulps have been discussed.

scholarly journals Type VI collagen microfibrils: evidence for a structural association with hyaluronan.

1992 ◽  
Vol 118 (4) ◽  
pp. 979-990 ◽  
Author(s):  
C M Kielty ◽  
S P Whittaker ◽  
M E Grant ◽  
C A Shuttleworth
Keyword(s):  
Gel Filtration ◽  
Microscopic Analysis ◽  
Connective Tissues ◽  
Binding Studies ◽  
Collagen Vi ◽  
Electron Microscopic ◽  
Type Vi Collagen ◽  
Structural Association ◽  
Fetal Bovine

Type VI collagen, a widespread structural component of connective tissues, has been isolated in abundance from fetal bovine skin by a procedure involving bacterial collagenase digestion under nonreducing, nondenaturing conditions and gel filtration chromatography. Rotary shadowing electron microscopic analysis revealed that the collagen VI was predominantly in the form of extensive intact microfibrillar arrays. These microfibrils were seen in association with hyaluronan, which was identified by its ability to bind the G1 fragment of cartilage proteoglycan. Treatment with highly purified hyaluronidase largely disrupted the collagen VI microfibrils into component tetramers, double tetramers, and short microfibrillar sections. Subsequent incubation of disrupted collagen VI in the presence of hyaluronan facilitated a partial repolymerization of the microfibrils. In vitro binding studies have also demonstrated that type VI collagen binds hyaluronan with a relatively high affinity. These studies demonstrate that a specific structural relationship exists between type VI collagen and hyaluronan. This association is likely to be of primary importance in the growth and remodeling processes of connective tissues.

Sign in / Sign up

Export Citation Format

Share Document