Sex-Hormone Genes and Gender Difference in Ultimatum Game: Experimental Evidence from China and Israel

2011 ◽  
Author(s):  
Soo Hong Chew ◽  
Richard P. Ebstein ◽  
Songfa Zhong
Keyword(s):  
Gender Difference ◽  
Experimental Evidence ◽  
Ultimatum Game ◽  
Sex Hormone ◽  
And Gender

scholarly journals Characterization of Two Ferroptosis Subtypes With Distinct Immune Infiltration and Gender Difference in Gastric Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Junfu Ma ◽  
Xin Hu ◽  
Yanxin Yao ◽  
Liuxing Wu ◽  
Chao Sheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gender Difference ◽  
Hormone Receptors ◽  
Immune Cell ◽  
Sex Hormone ◽  
Tumor Patients ◽  
Chemotherapy Drugs ◽  
Subtype B ◽  
And Gender ◽  
Subtype A

Background: Iron is an essential nutrient involved in the redox cycle and the formation of free radicals. The reprogramming of iron metabolism is the main link to tumor cell survival. Ferroptosis is an iron-dependent form of regulated cell death associated with cancer; the characteristics of ferroptosis in cancers are still uncertain. This study aimed to explore the application value and gender difference of ferroptosis in prognosis and immune prediction to provide clues for targeted therapy of gastric cancer.Methods: We comprehensively evaluated the ferroptosis levels of 1,404 gastric cancer samples from six independent GC cohorts based on ferroptosis-related specific genes and systematically correlated ferroptosis with immune cell infiltrating and gender characteristics. The ferroptosis score was constructed to quantify the ferroptosis levels of individual tumors using principal component analysis (PCA) algorithms.Results: We identified two distinct ferroptosis subtypes in gastric cancer, namely Subtype-A and Subtype-B. We found that male patients in Subtype-B had the worst prognosis in contrast with the other groups. Three sex hormone receptors (AR, ER, and PR) in Subtype-B tumor patients were higher than in Subtype-A tumor patients in GC, while the HER2 displayed an opposite trend. We developed a risk model termed ferroptosis score to evaluate ferroptosis levels within individual tumors. The low-ferroptosis score group was characterized by activation of immune cells and increased mutation burden, which is also linked to increased neoantigen load and enhanced response to anti-PD-1/L1 immunotherapy. The patients with a low-ferroptosis score showed a high microsatellite instability status (MSI-H) and had a higher response to immunotherapy. Furthermore, the patients with low-ferroptosis scores have a lower estimated IC50 in the several chemotherapy drugs, including paclitaxel, gemcitabine, and methotrexate.Conclusions: We revealed that sex hormone receptors and immune cell infiltration were markedly different between ferroptosis subtypes in GC patients. The results suggested that gender difference may be critical when the ferroptosis-related strategy is applied in GC treatment. Further, ferroptosis levels were identified with an extreme variety of prognosis and tumor immune characteristics, which might benefit GC individualized treatment.

Sex Hormone and Gender Difference?Role of Testosterone on Male Predominance in Brugada Syndrome

2007 ◽  
Vol 18 (4) ◽  
pp. 415-421 ◽  
Author(s):  
WATARU SHIMIZU ◽  
KIYOTAKA MATSUO ◽  
YOSHIHIRO KOKUBO ◽  
KAZUHIRO SATOMI ◽  
TAKASHI KURITA ◽  
...  
Keyword(s):  
Gender Difference ◽  
Brugada Syndrome ◽  
Sex Hormone ◽  
Male Predominance ◽  
And Gender

scholarly journals The Prevalence and Patterns of Palmaris Longus Muscle Absence in an Iranian Population

2019 ◽  
Vol 9 (4) ◽  
pp. 279-282
Author(s):  
Mehdi Forouzesh ◽  
Abdolrazagh Barzegar ◽  
Fardin Fallah
Keyword(s):  
Gender Difference ◽  
Clinical Importance ◽  
Tendon Graft ◽  
Iranian Population ◽  
Geographical Variability ◽  
Palmaris Longus ◽  
Longus Muscle ◽  
Palmaris Longus Muscle ◽  
And Gender ◽  
Gender Specific

Palmaris Longus (PL) is a muscle of the forearm, i.e., not functionally necessary and does not exist in all people. It is a choice for tendon graft and investigating its prevalence is of clinical importance. During April-October 2009, 102 cadavers (78 males, 24 females) were bilaterally necropsied for PL exploration in Zanjan City, Iran. PL Absence (PLA) was observed in 37 (36.3%) cases (28 males, 9 females). PLA prevalence was similar in men (36%) and women (37.5%). Of PLA cases, 19 (51%) were unilateral (14 males, 5 females), and 18 (49%) were bilateral (14 males, 4 females). In conclusion, PLA prevalence of 36.3% in our population was similar to other studies conducted in Iran. We found no gender difference in PLA prevalence and its patterns. Due to geographical variability in PLA rate, future regional and national studies with more magnificent sample sizes are recommended to determine the prevalence and gender-specific patterns of PLA.

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