Noble Gases Deliver Cool Dates from Hot Rocks

Elements ◽  
2020 ◽  
Vol 16 (5) ◽  
pp. 303-309 ◽  
Author(s):  
Cécile Gautheron ◽  
Peter K. Zeitler

Heat transfer in the solid Earth drives processes that modify temperatures, leaving behind a clear signature that we can measure using noble gas thermochronology. This allows us to record the thermal histories of rocks and obtain the timing, rate, and magnitude of phenomena such as erosion, deformation, and fluid flow. This is done by measuring the net balance between the accumulation of noble gas atoms from radioactive decay and their loss by temperature-activated diffusion in mineral grains. Together with knowledge about noble gas diffusion in common minerals, we can then use inverse models of this accumulation–diffusion balance to recover thermal histories. This approach is now a mainstream method by which to study geodynamics and Earth evolution.

2019 ◽  
Vol 127 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Déborah Le Nogue ◽  
Jérémie Lavaur ◽  
Aude Milet ◽  
Juan Fernando Ramirez-Gil ◽  
Ira Katz ◽  
...  

AbstractUsing midbrain cultures, we previously demonstrated that the noble gas xenon is robustly protective for dopamine (DA) neurons exposed to l-trans-pyrrolidine-2,4-dicarboxylate (PDC), an inhibitor of glutamate uptake used to generate sustained, low-level excitotoxic insults. DA cell rescue was observed in conditions where the control atmosphere for cell culture was substituted with a gas mix, comprising the same amount of oxygen (20%) and carbon dioxide (5%) but 75% of xenon instead of nitrogen. In the present study, we first aimed to determine whether DA cell rescue against PDC remains detectable when concentrations of xenon are progressively reduced in the cell culture atmosphere. Besides, we also sought to compare the effect of xenon to that of other noble gases, including helium, neon and krypton. Our results show that the protective effect of xenon for DA neurons was concentration-dependent with an IC50 estimated at about 44%. We also established that none of the other noble gases tested in this study protected DA neurons from PDC-mediated insults. Xenon’s effectiveness was most probably due to its unique capacity to block NMDA glutamate receptors. Besides, mathematical modeling of gas diffusion in the culture medium revealed that the concentration reached by xenon at the cell layer level is the highest of all noble gases when neurodegeneration is underway. Altogether, our data suggest that xenon may be of potential therapeutic value in Parkinson disease, a chronic neurodegenerative condition where DA neurons appear vulnerable to slow excitotoxicity.


2017 ◽  
Vol 20 (4) ◽  
pp. 58-63
Author(s):  
K. Maksymenko-Sheiko ◽  
◽  
Yu. Litvinova ◽  
T. Sheyko ◽  
M. Khazhmuradov ◽  
...  

2015 ◽  
Vol 9 (3) ◽  
pp. 242 ◽  
Author(s):  
Efstathios Kaloudis ◽  
Dimitris Siachos ◽  
Konstantinos Stefanos Nikas

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