A simple, reproducible and efficient High Performance Thin Layer Chromatography method was developed for Lisinopril dihydrate in bulk drug and dosage form. A constant application rate of 0.1 ml/s with nitrogen aspirator was used, and the space between two bands was 6 mm. The slit dimension was 5 × 0.45 mm, and the scanning speed was 10 mm/s. The mobile phase consisted of n-butanol: methanol: ammonia in the ratio of 3.0: 1.0: 1.0 (v/v/v). The retention time (min) and linearity range (μl) for Lisinopril was (0.20) and (1-5) respectively. The method so developed was validated for its accuracy and precision. The LOD and LOQ were found to be 0.050237 and 0.152233 for Lisinopril respectively. The accuracy was found to be 98.88%. The developed method was found to be accurate, precise and selective for determination of Lisinopril in bulk and dosage form.
Calibration of soil fumigant equipment and determination of soil fumigant application rate are two of the most important factors contributing to the success or failure of pest control efficacy and crop production response, yet generate some of the greatest confusion among many researchers and growers alike. This 5-page fact sheet was written by J.W. Noling and published by the UF Department of Entomology and Nematology, December 2012.
http://edis.ifas.ufl.edu/in404
Abstract
A method was developed using a selective nitrogen-phosphorus detector to determine the combined total residues, as the oxygen analogs, of fensulfothion (O,O-diethyl O-[p-(methylsulfinyl)-phenyl] phosphorothioate) and its 3 metabolites. The procedure was used to determine harvest residues in Chinese cabbage, Japanese radish, and turnips treated with 2 application rates of fensulfothion. Residues found after application of 2 oz active ingredient (AI)/100 lineal ft of row ranged from 0.026 ppm for Japanese radish to 1.543 ppm for turnip greens. When the application rate was doubled, the amount of residue found was approximately doubled.
In a 2-yr study, asparagus spears from established plantings at two sites in British Columbia and one site in Ontario were analyzed for terbacil residues following preemergence and early postemergence applications of terbacil at 0.6, 1.1 and 2.2 kg ha−1. Gas chromatographic determination of terbacil residues using N-specific alkali flame ionization detection indicated that at one site, maximum terbacil residues in the preemergence samples were 14 ± 3 μg kg−1 for the 2.2 kg ha−1 application rate, whereas maximum residues in the early postemergence samples for the 2.2 kg ha−1 application rate were 493 ± 250 μg kg−1 at a second site. Recoveries of terbacil from fortified asparagus tissue were 96 ± 19%, 87.2 ± 11.9% and 83.3 ± 7.8% at 10, 50 and 100 μg kg−1, respectively. Key words: Asparagus officinalis L., terbacil, residues, gas chromatography, asparagus
It is now possible to determine proper motions of high-velocity objects in such a way as to obtain with some accuracy the velocity vector relevant to the Sun. If a potential field of the Galaxy is assumed, one can compute an actual orbit. A determination of the velocity of the globular clusterωCentauri has recently been completed at Greenwich, and it is found that the orbit is strongly retrograde in the Galaxy. Similar calculations may be made, though with less certainty, in the case of RR Lyrae variable stars.
Using the new reductions of the IUE light curves by Sonneborn et al. (1997) and an extensive set of HST images of SN 1987A we have repeated and improved Panagia et al. (1991) analysis to obtain a better determination of the distance to the supernova. In this way we have derived an absolute size of the ringRabs= (6.23 ± 0.08) x 1017cm and an angular sizeR″ = 808 ± 17 mas, which give a distance to the supernovad(SN1987A) = 51.4 ± 1.2 kpc and a distance modulusm–M(SN1987A) = 18.55 ± 0.05. Allowing for a displacement of SN 1987A position relative to the LMC center, the distance to the barycenter of the Large Magellanic Cloud is also estimated to bed(LMC) = 52.0±1.3 kpc, which corresponds to a distance modulus ofm–M(LMC) = 18.58±0.05.
A symposium on the future of the International Latitude Service (I. L. S.) is to be held in Helsinki in July 1960. My report for the symposium consists of two parts. Part I, denoded (Mk I) was published [1] earlier in 1960 under the title “Latitude and Longitude, and the Secular Motion of the Pole”. Part II is the present paper, denoded (Mk II).
In South Africa the modern outlook towards time may be said to have started in 1948. Both the two major observatories, The Royal Observatory in Cape Town and the Union Observatory (now known as the Republic Observatory) in Johannesburg had, of course, been involved in the astronomical determination of time almost from their inception, and the Johannesburg Observatory has been responsible for the official time of South Africa since 1908. However the pendulum clocks then in use could not be relied on to provide an accuracy better than about 1/10 second, which was of the same order as that of the astronomical observations. It is doubtful if much use was made of even this limited accuracy outside the two observatories, and although there may – occasionally have been a demand for more accurate time, it was certainly not voiced.
AbstractPrecise measurements of heliographic position of solar filaments were used for determination of the proper motion of solar filaments on the time-scale of days. The filaments have a tendency to make a shaking or waving of the external structure and to make a general movement of whole filament body, coinciding with the transport of the magnetic flux in the photosphere. The velocity scatter of individual measured points is about one order higher than the accuracy of measurements.
Development of analytical method and validation for determination of Lisinopril dihydrate in bulk drug and dosage form using HPTLC method