scholarly journals Disposition of Amorolfine Hydrochloride in Rats. Percutaneous Absorption, Distribution and Excretion after Single Dermal Application.

1994 ◽  
Vol 9 (4) ◽  
pp. 499-509
Author(s):  
Masakatsu KOMURO ◽  
Takao OKAMURA ◽  
Akira IDESAWA ◽  
Tsuyoshi OOIE ◽  
Ryuzo YUASA ◽  
...  
Keyword(s):  
Percutaneous Absorption ◽  
Dermal Application

scholarly journals Absorption, Pharmacokinetics, and Safety of Triclosan after Dermal Administration

2009 ◽  
Vol 54 (1) ◽  
pp. 570-572 ◽  
Author(s):  
Christian Queckenberg ◽  
Jürgen Meins ◽  
Bertil Wachall ◽  
Oxana Doroshyenko ◽  
Dorota Tomalik-Scharte ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Standard Deviation ◽  
Percutaneous Absorption ◽  
Systemic Exposure ◽  
Adult Dose ◽  
Adverse Effect Level ◽  
Effect Level ◽  
Dermal Administration ◽  
Daily Application ◽  
Dermal Application

ABSTRACT We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% ± 2.1% of the dose (mean ± standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams.

Percutaneous absorption, disposition, metabolism, and excretion of 14C-labelled Cyoctol in humans after a single dermal application

1990 ◽  
Vol 65 (1-2) ◽  
pp. 77-84 ◽  
Author(s):  
Johann W. Wiechers ◽  
Renella E. Herder ◽  
Ben F.H. Drenth ◽  
Rokus A. de Zeeuw
Keyword(s):  
Percutaneous Absorption ◽  
Dermal Application

Studies on Adrenocortical Suppression Following Percutaneous Absorption of Topical Corticosteroids

1973 ◽  
Vol 35 (4) ◽  
pp. 472-476 ◽  
Author(s):  
Shuhei SHIMAO ◽  
Yasuyuki SHIMIZU ◽  
Motoyuki MIHARA ◽  
Toshiaki USUI ◽  
Hiroko KAWAMOTO
Keyword(s):  
Percutaneous Absorption ◽  
Topical Corticosteroids
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