scholarly journals Metabolic Fate of a Benzoylphenylurea Derivative, HO-221. (II). Repeated Dosing Study and Metabolism in Rats.

1994 ◽  
Vol 9 (4) ◽  
pp. 437-457
Author(s):  
Kiyoshi OHYAMA ◽  
Hiroshi OKADA ◽  
Nobuo KONDO ◽  
Yoshio ESUMI ◽  
Matsuo TAKAICHI ◽  
...  
Keyword(s):  
Metabolic Fate ◽  
Repeated Dosing

scholarly journals Studies on Metabolic Fate of 14C-RU44570: Placental Transfer, Transfer into Milk, Absorption Site and Repeated Dosing in Rats, and Metabolism in Rats and Dogs.

1994 ◽  
Vol 9 (6) ◽  
pp. 762-792
Author(s):  
Masashi HIRAYAMA ◽  
Tatsuo MANABE ◽  
Yoshinari HASEGAWA ◽  
Yoshiharu KATAMI ◽  
Katsumi UOHAMA ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Metabolic Fate ◽  
Repeated Dosing

Metabolic fate of the new .BETA.-adrenoceptor antagonist, bisoprolol, in animals (3): Foeto-placental transfer and excretion into milk of 14C-bisoprolol in rats.

1989 ◽  
Vol 4 (2) ◽  
pp. 173-185
Author(s):  
Yasuhiro YAMADA ◽  
Mika NAKAHARA ◽  
Kazuaki NAITO ◽  
Michihiro KOHNO ◽  
Minezo OTSUKA ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Metabolic Fate ◽  
Beta Adrenoceptor ◽  
Adrenoceptor Antagonist

Studies on the Metabolic Fate of Felodipine. (I): Absorption, Distribution, Metabolism and Excretion after a Single Administration to Rats.

1991 ◽  
Vol 6 (5) ◽  
pp. 717-747
Author(s):  
Kazuo UNO ◽  
Satoru YAMAGAMI ◽  
Syoryo HAYASHI ◽  
Shigeru TABATA ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Single Administration ◽  
Metabolic Fate

Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved

2021 ◽  
pp. 147677
Author(s):  
Guangqiang Wang ◽  
Hongna Zhang ◽  
Jianan Zhang ◽  
Katherine Z. Sanidad ◽  
Vladimir Yeliseyev ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Metabolic Fate ◽  
Environmental Chemical

scholarly journals Pyrrolidinyl Synthetic Cathinones α-PHP and 4F-α-PVP Metabolite Profiling Using Human Hepatocyte Incubations

2020 ◽  
Vol 22 (1) ◽  
pp. 230
Author(s):  
Jeremy Carlier ◽  
Xingxing Diao ◽  
Raffaele Giorgetti ◽  
Francesco P. Busardò ◽  
Marilyn A. Huestis
Keyword(s):  
Metabolite Profiling ◽  
Human Liver ◽  
Liver Microsomes ◽  
Drug Market ◽  
Metabolite Profile ◽  
Illegal Drug ◽  
Human Hepatocyte ◽  
Synthetic Cathinones ◽  
Metabolic Fate ◽  
Analytical Standards

For more than ten years, new synthetic cathinones (SCs) mimicking the effects of controlled cocaine-like stimulants have flooded the illegal drug market, causing numerous intoxications and fatalities. There are often no data on the pharmacokinetics of these substances when they first emerge onto the market. However, the detection of SC metabolites is often critical in order to prove consumption in clinical and forensic settings. In this research, the metabolite profile of two pyrrolidinyl SCs, α-pyrrolidinohexaphenone (α-PHP) and 4′′-fluoro-α-pyrrolidinovalerophenone (4F-α-PVP), were characterized to identify optimal intake markers. Experiments were conducted using pooled human hepatocyte incubations followed by liquid chromatography–high-resolution tandem mass spectrometry and data-mining software. We suggest α-PHP dihydroxy-pyrrolidinyl, α-PHP hexanol, α-PHP 2′-keto-pyrrolidinyl-hexanol, and α-PHP 2′-keto-pyrrolidinyl as markers of α-PHP use, and 4F-α-PVP dihydroxy-pyrrolidinyl, 4F-α-PVP hexanol, 4F-α-PVP 2′-keto-pyrrolidinyl-hexanol, and 4F-α-PVP 2′-keto-pyrrolidinyl as markers of 4F-α-PVP use. These results represent the first data available on 4F-α-PVP metabolism. The metabolic fate of α-PHP was previously studied using human liver microsomes and urine samples from α-PHP users. We identified an additional major metabolite (α-PHP dihydroxy-pyrrolidinyl) that might be crucial for documenting exposure to α-PHP. Further experiments with suitable analytical standards, which are yet to be synthesized, and authentic specimens should be conducted to confirm these results.

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