scholarly journals Metabolic Disposition of DQ-2556, a New Parenteral Cephalosporin, in Rats following Multiple Doses.

1993 ◽  
Vol 8 (4) ◽  
pp. 403-412
Author(s):  
Kyuichi MATSUBAYASHI ◽  
Shozo SHINTANI ◽  
Haruo TACHIZAWA
Keyword(s):  
Multiple Doses ◽  
Metabolic Disposition

Dose-Response Aggregometry in Maternal/Neonatal Platelets

1988 ◽  
Vol 60 (02) ◽  
pp. 314-318 ◽  
Author(s):  
A M A Gader ◽  
H Bahakim ◽  
F A Jabbar ◽  
A L Lambourne ◽  
T H Gaafar ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Dose Response ◽  
Lag Phase ◽  
Phase Slope ◽  
Multiple Doses ◽  
Nonpregnant Adult ◽  
Aggregation Of Platelets

SummaryThe aggregation of platelets collected from maternal/neonatal pairs (n = 240) at the time of childbirth, was studied in response to multiple doses of ADP, collagen, arachidonic acid and ristocetin. Similar responses were obtained from healthy nonpregnant adult controls for comparison. The lag phase, slope of the aggregation curves as well as maximum aggregation (MA%) were recorded and analysed. Neonatal and adult platelets exhibited more enhanced responses to decreasing doses of ADP, arachidonic acid and ristocetin, than maternal platelets. These enhanced responses were exhibited more consistantly in the slopes of the aggregation curves than in MA%. Although neonatal platelets have shown longer lag phase in their responses to collagen, the rate of the aggregation reaction was significantly faster than maternal platelets, with no differences in MA%. These results contradict many previous reports suggesting impaired aggregation responses of neonatal platelets to these agonist. The possible reasons for these contradictions were discussed.

The acute effects of multiple doses of methamphetamine on locomotor activity and anxiety-like behavior in adolescent and adult mice

2021 ◽  
Vol 405 ◽  
pp. 113186
Author(s):  
Hayley A. Ortman ◽  
Mikayla L. Newby ◽  
Jonathan Acevedo ◽  
Jessica A. Siegel
Keyword(s):  
Locomotor Activity ◽  
Acute Effects ◽  
Adult Mice ◽  
Multiple Doses

Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans

2021 ◽  
Author(s):  
Jian Meng ◽  
Hua Zhang ◽  
Jing-jing Bao ◽  
Zhen-dong Chen ◽  
Xiao-yun Liu ◽  
...  
Keyword(s):  
Covalent Inhibitor ◽  
Metabolic Disposition

Effect of multiple doses of cadmium on glucose metabolism and insulin secretion in the rat

1975 ◽  
Vol 31 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Dionyssis S. Ithakissios ◽  
Taghi Ghafghazi ◽  
John H. Mennear ◽  
Wayne V. Kessler
Keyword(s):  
Insulin Secretion ◽  
Glucose Metabolism ◽  
Multiple Doses
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