scholarly journals Metabolic Fate of Dopamine Prodrug TA-870. (3): Foeto-placental Transfer and Excretion into Milk after Oral Administration of 14C-TA-870 to Rats.

1991 ◽  
Vol 6 (2) ◽  
pp. 267-275
Author(s):  
Hiroshi ENDO ◽  
Masayoshi YOSHIKAWA ◽  
Kumiko HOSHINO ◽  
Osasi TAKAITI
Keyword(s):  
Oral Administration ◽  
Placental Transfer ◽  
Metabolic Fate

Metabolic fate of the new .BETA.-adrenoceptor antagonist, bisoprolol, in animals (3): Foeto-placental transfer and excretion into milk of 14C-bisoprolol in rats.

1989 ◽  
Vol 4 (2) ◽  
pp. 173-185
Author(s):  
Yasuhiro YAMADA ◽  
Mika NAKAHARA ◽  
Kazuaki NAITO ◽  
Michihiro KOHNO ◽  
Minezo OTSUKA ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Metabolic Fate ◽  
Beta Adrenoceptor ◽  
Adrenoceptor Antagonist

Metabolic fate of clopidol after repeated oral administration to rabbits

1975 ◽  
Vol 23 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Brian D. Cameron ◽  
L. F. Chasseaud ◽  
David R. Hawkins
Keyword(s):  
Oral Administration ◽  
Metabolic Fate

scholarly journals Studies on Metabolic Fate of 14C-RU44570: Placental Transfer, Transfer into Milk, Absorption Site and Repeated Dosing in Rats, and Metabolism in Rats and Dogs.

1994 ◽  
Vol 9 (6) ◽  
pp. 762-792
Author(s):  
Masashi HIRAYAMA ◽  
Tatsuo MANABE ◽  
Yoshinari HASEGAWA ◽  
Yoshiharu KATAMI ◽  
Katsumi UOHAMA ◽  
...  
Keyword(s):  
Placental Transfer ◽  
Metabolic Fate ◽  
Repeated Dosing

scholarly journals Studies on the Metabolic Fate of SS320A. (3): Absorption, Metabolism and Excretion of 14C-SS320A after Single Oral Administration in Dogs.

1997 ◽  
Vol 12 (5) ◽  
pp. 525-530
Author(s):  
Toshihiro KOGURE ◽  
Rie IKEDA ◽  
Motohiro SUZUKI ◽  
Takayuki OIKAWA ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Metabolic Fate ◽  
Single Oral Administration

scholarly journals Vitamin K Deficiency Bleeding in Infancy

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 780
Author(s):  
Shunsuke Araki ◽  
Akira Shirahata
Keyword(s):  
Oral Administration ◽  
Vitamin K ◽  
Placental Transfer ◽  
Late Onset ◽  
Newborn Infants ◽  
Coagulation Factors ◽  
Epidemiological Studies ◽  
Vitamin K Deficiency ◽  
Vitamin K Deficiency Bleeding ◽  
K Deficiency

Vitamin K is essential for the synthesis of few coagulation factors. Infants can easily develop vitamin K deficiency owing to poor placental transfer, low vitamin K content in breast milk, and poor intestinal absorption due to immature gut flora and malabsorption. Vitamin K deficiency bleeding (VKDB) in infancy is classified according to the time of presentation: early (within 24 h), classic (within 1 week after birth), and late (between 2 week and 6 months of age). VKDB in infancy, particularly late-onset VKDB, can be life-threatening. Therefore, all infants, including newborn infants, should receive vitamin K prophylaxis. Exclusive breastfeeding and cholestasis are closely associated with this deficiency and result in late-onset VKDB. Intramuscular prophylactic injections reduce the incidence of early-onset, classic, and late-onset VKDB. However, the prophylaxis strategy has recently been inclined toward oral administration because it is easier, safer, and cheaper to administer than intramuscular injection. Several epidemiological studies have shown that vitamin K oral administration is effective in the prevention of VKDB in infancy; however, the success of oral prophylaxis depends on the protocol regimen and parent compliance. Further national surveillance and studies are warranted to reveal the optimal prophylaxis regimen in term and preterm infants.

scholarly journals Studies on the Metabolic Fate of Pramipexole (SND 919 CL2Y). (I). Absorption, Distribution and Excretion after a Single Oral Administration to Rats.

1999 ◽  
Vol 14 (4) ◽  
pp. 300-308
Author(s):  
Kazutoshi YOKOYAMA ◽  
Yoko OIWA ◽  
Rumi IMANISHI ◽  
Makoto SHIMASAKI ◽  
Wataru KISHIMOTO ◽  
...  
Keyword(s):  
Oral Administration ◽  
Metabolic Fate ◽  
Single Oral Administration ◽  
Snd 919
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