scholarly journals Studies on the Metabolic Fate of Azuletil Sodium. (VI). Distribution of Radioactivity in Gastric tissues after Oral Administration to Rats with Acetic Acid-Induced Gastric Ulcer.

1990 ◽  
Vol 5 (6) ◽  
pp. 845-851
Author(s):  
Masao SATO ◽  
Hiroaki SUZAKA ◽  
Akira TOMIYAMA ◽  
Hiroshi MIYAZAKI
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Oral Administration ◽  
Metabolic Fate

Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A153-A153
Author(s):  
S MIYAMOTO ◽  
K KATO ◽  
Y ISHII ◽  
S ASAI ◽  
T NAGAISHI ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Amino Acid ◽  
Amino Acid Transporter ◽  
Chronic Gastric Ulcer ◽  
Acid Transporter

Metabolic fate of clopidol after repeated oral administration to rabbits

1975 ◽  
Vol 23 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Brian D. Cameron ◽  
L. F. Chasseaud ◽  
David R. Hawkins
Keyword(s):  
Oral Administration ◽  
Metabolic Fate

Comparison Between Omental Implantation and Omental Patch for Perforated Acetic Acid-Induced Gastric Ulcer in Rats

2005 ◽  
Vol 13 (1) ◽  
pp. A14-A14
Author(s):  
Yasunori Matoba ◽  
Akira Tokunaga ◽  
Yukichi Moriyama ◽  
Shinya Iida ◽  
Norio Matsukura ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Omental Patch

scholarly journals Rabbit gastric ulcer models: comparison and evaluation of acetic acid-induced ulcer and mucosectomy-induced ulcer

2013 ◽  
Vol 29 (2) ◽  
pp. 96 ◽  
Author(s):  
Jin Hee Maeng ◽  
Eunhye Lee ◽  
Don Haeng Lee ◽  
Su-Geun Yang
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Models Comparison

scholarly journals Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

2008 ◽  
Vol 51 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Cristina Setim Freitas ◽  
Cristiane Hatsuko Baggio ◽  
Samanta Luiza Araújo ◽  
Maria Consuelo Andrade Marques
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Healing Process ◽  
Intraperitoneal Administration ◽  
Oral Route ◽  
Chronic Gastric Ulcer ◽  
Pfaffia Glomerata ◽  
Tissue Healing

The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.

scholarly journals Effect of aqueous extract of aloe vera leaves on gut-brain axis response following acetic acid -induced gastric ulcer in male rats

2014 ◽  
Vol 6 (2) ◽  
pp. 347-357
Author(s):  
M Sabaghian ◽  
Z Keshavarzi ◽  
B Bibak ◽  
M Vatanchian ◽  
T Mohammad Rezapour
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Aloe Vera ◽  
Male Rats

scholarly journals Studies on the Metabolic Fate of SS320A. (3): Absorption, Metabolism and Excretion of 14C-SS320A after Single Oral Administration in Dogs.

1997 ◽  
Vol 12 (5) ◽  
pp. 525-530
Author(s):  
Toshihiro KOGURE ◽  
Rie IKEDA ◽  
Motohiro SUZUKI ◽  
Takayuki OIKAWA ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Metabolic Fate ◽  
Single Oral Administration

scholarly journals Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

2020 ◽  
Vol 21 (7) ◽  
pp. 2577 ◽  
Author(s):  
Cuizhu Wang ◽  
Yuze Yuan ◽  
He Pan ◽  
Alan Chen-Yu Hsu ◽  
Jinluan Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Growth Factor ◽  
Gastric Mucosa ◽  
Epidermal Growth Factor ◽  
Serum Levels ◽  
Gastroprotective Effect ◽  
Epidermal Growth ◽  
Oxide Synthase

Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.

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