Three Novel Single Nucleotide Polymorphisms of UGT1A9 in a Thai Population

2009 ◽  
Vol 24 (5) ◽  
pp. 482-485 ◽  
Author(s):  
Porntipa Korprasertthaworn ◽  
Wandee Udomuksorn ◽  
Krongtong Yoovathaworn
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Thai Population ◽  
Single Nucleotide

scholarly journals Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Niwat Saksit ◽  
Nontaya Nakkam ◽  
Parinya Konyoung ◽  
Usanee Khunarkornsiri ◽  
Wongwiwat Tassaneeyakul ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Strong Association ◽  
Chromosome 6 ◽  
Surrogate Markers ◽  
Nucleotide Polymorphisms ◽  
Thai Population ◽  
Single Nucleotide ◽  
Life Threatening ◽  
Sensitivity Specificity ◽  
Degree Of Association

Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between the HLA-B∗58 : 01 allele and allopurinol-induced SCARs is well recognized. Screening for HLA-B∗58 : 01 allele before prescribing allopurinol in some populations has been recommended. Several single-nucleotide polymorphisms (SNPs) in chromosome 6 have been found to be tightly linked with the HLA allele, and these SNPs have been proposed as surrogate markers of the HLA-B∗58 : 01 allele. This study aimed to evaluate the association between three SNPs in chromosome 6 and allopurinol-induced SCARs in a Thai population. The linkage disequilibrium between the HLA-B∗58 : 01 allele and these SNPs was also evaluated. Results showed that three SNPs including rs9263726, rs2734583, and rs3099844 were significantly associated with allopurinol-induced SCARs but with a lower degree of association when compared with the HLA-B∗58 : 01 allele. The sensitivity, specificity, PPV, and NPV of these SNPs were comparable to those of the HLA-B∗58 : 01 allele. Although detection of the SNP is simpler and less expensive compared with that of the HLA-B∗58 : 01 allele, these SNPs were not perfectly linked with the HLA-B∗58 : 01 allele. Screening using these SNPs as surrogate markers of the HLA-B∗58 : 01 allele to avoid SCARs prior to allopurinol administration needs caution because of their imperfect linkage with the HLA-B∗58 : 01 allele.

scholarly journals Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population

2020 ◽  
Vol 11 ◽  
Author(s):  
Chalitpon Na nakorn ◽  
Jariya Waisayarat ◽  
Charungthai Dejthevaporn ◽  
Pornpen Srisawasdi ◽  
Sansanee Wongwaisayawan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Genetic Variations ◽  
Nucleotide Polymorphisms ◽  
Thai Population ◽  
Single Nucleotide

Single nucleotide polymorphisms and haplotypes of protein C and protein S genes in the Thai population

2006 ◽  
Vol 17 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Worawan Chumpia ◽  
Chayanon Peerapittayamongkol ◽  
Pantep Angchaisuksiri ◽  
Nantarat Komanasin ◽  
Koichiro Muta ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Protein C ◽  
Protein S ◽  
Nucleotide Polymorphisms ◽  
Thai Population ◽  
Single Nucleotide ◽  
S Genes

scholarly journals Association between Vitamin D Receptor Single-Nucleotide Polymorphisms and Colorectal Cancer in the Thai Population: A Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Sirinporn Suksawatamnuay ◽  
Supachaya Sriphoosanaphan ◽  
Prapimphan Aumpansub ◽  
Satimai Aniwan ◽  
Kessarin Thanapirom ◽  
...  
Keyword(s):  
Vitamin D ◽  
Single Nucleotide Polymorphisms ◽  
Vitamin D Receptor ◽  
Colorectal Carcinogenesis ◽  
Nucleotide Polymorphisms ◽  
Control Groups ◽  
Thai Population ◽  
Single Nucleotide ◽  
And Control ◽  
Control Study

Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. A large number of studies demonstrated the association of low vitamin D levels and variations in five common single nucleotide polymorphisms (SNPs), FokI, BsmI, Tru9I, ApaI, and TaqI, with the risk of several cancers, including colorectal cancers. However, these associations vary among different populations. This case-control study was aimed at analysing whether common single-nucleotide polymorphisms (SNPs) and haplotypes of the vitamin D receptor (VDR) gene contribute to colorectal carcinogenesis in the Thai population. We enrolled 364 Thai participants from King Chulalongkorn Memorial Hospital between 2014 and 2015. Half of the participants underwent colonoscopy and showed a normal colon without polyps (control group) and another half were newly diagnosed patients with colorectal cancer (CRC) by colonoscopy during the index period, were under treatment, or were followed up at the outpatient clinic (case group). Differences in allele and genotype frequencies of five common VDR SNPs, between the case and control groups, were the primary outcome measures. Differences in haplotype frequencies of the five SNPs between the case and control groups were the secondary outcome measures. Among the 364 participants, baseline characteristics were not significantly different between the case and control groups, except for the higher proportion of males in the CRC group. The mean vitamin D level was also not significantly different between the case and control groups (24.6±9.1 vs. 25.3±10.6 ng/mL, p=0.52). None of the five VDR SNPs was associated with CRC development (p>0.05). However, haplotype analysis of these polymorphisms demonstrated that the AGGT haplotype was associated with a decreased risk of CRC (odds ratio 0.24, 95% confidence interval 0.07-0.81, p=0.01). The AGGT haplotype was associated with a lower risk of CRC in the Thai population. This genetic linkage might support the role of vitamin D in colorectal carcinogenesis. However, this finding requires further study within a larger population and a multivariate analysis of other established risk factors.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide
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