scholarly journals Long-term Levothyroxine Treatment Decreases the Oral Bioavailability of Cyclosporin A by Inducing P-glycoprotein in Small Intestine

2005 ◽  
Vol 20 (5) ◽  
pp. 324-330 ◽  
Author(s):  
Mingji Jin ◽  
Tsutomu Shimada ◽  
Miki Shintani ◽  
Koichi Yokogawa ◽  
Masaaki Nomura ◽  
...  
Keyword(s):  
Small Intestine ◽  
Cyclosporin A ◽  
Oral Bioavailability ◽  
P Glycoprotein ◽  
Levothyroxine Treatment

Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone

2006 ◽  
Vol 309 (1-2) ◽  
pp. 81-86 ◽  
Author(s):  
Mingji Jin ◽  
Tsutomu Shimada ◽  
Koichi Yokogawa ◽  
Masaaki Nomura ◽  
Yukio Kato ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Oral Bioavailability ◽  
P Glycoprotein

Verapamil and cyclosporin a sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration

1990 ◽  
Vol 10 (2) ◽  
pp. 231-237 ◽  
Author(s):  
P. Nygren ◽  
R. Larsson
Keyword(s):  
Cyclosporin A ◽  
Drug Sensitivity ◽  
Human Kidney ◽  
Chemotherapeutic Drug ◽  
Long Term Effects ◽  
Adenocarcinoma Cell Line ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Sensitizing Effect

Vincristine (Vcr) dose dependently inhibited growth of the kidney adenocarcinoma cell line ACHN during 4 days of culture. Verapamil (Ver) at 10 μM and cyclosporin A (CsA) at 1 μg/ml had no effect on cell growth but significantly potentiated the action of Vcr, despite the absence of the multidrug resistance associated membrane P-glycoprotein (P-gp). Neither Ver nor CsA had any acute or long term effects on cytoplasmic free Ca2+ concentration (Ca2+i), except for a small Ver induced increase after 36 h of incubation. The results indicate that Ver and CsA may have a sensitizing effect on chemotherapeutic drug sensitivity also in absence of P-gp. However, these effects are probably not mediated by changes in Ca2+i.

scholarly journals Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice

2006 ◽  
Vol 72 (8) ◽  
pp. 1042-1050 ◽  
Author(s):  
Mingji Jin ◽  
Tsutomu Shimada ◽  
Koichi Yokogawa ◽  
Masaaki Nomura ◽  
Junko Ishizaki ◽  
...  
Keyword(s):  
Small Intestine ◽  
Cyclosporin A ◽  
P Glycoprotein

scholarly journals A long-term survivor of clear cell sarcoma-like tumor of the gastrointestinal tract with liver metastasis: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Takuhisa Okada ◽  
Yasumitsu Hirano ◽  
Shintaro Ishikawa ◽  
Hiroka Kondo ◽  
Toshimasa Ishii ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Node ◽  
Gastrointestinal Tract ◽  
Liver Metastasis ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

Abstract Background Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLTGT) is extremely rare. It is a mesenchymal neoplasm that usually forms in the small intestine of adolescents and young adults, is prone to local recurrence and metastasis, and has a high mortality rate. We report a patient with CCSLTGT with lymph node- and liver metastases, who continues to survive 6 years after initial surgical resection. Case presentation A 38-year-old woman presented with lightheadedness. Laboratory analysis revealed anemia (hemoglobin, 6.7 g/dL), and enhanced computed tomography (CT) demonstrated a mass in the small intestine, about 6 cm in diameter, with swelling of 2 regional lymph nodes. Double-balloon small intestine endoscopic examination revealed a tumor accompanied by an ulcer; the biopsy findings suggested a primary cancer of the small intestine. She was admitted, and we then performed a laparotomy for partial resection of the small intestine with lymph node dissection. Pathologic examination revealed CCSLTGT with regional lymph node metastases. About 3 years later, follow-up CT revealed a single liver metastasis. Consequently, she underwent a laparoscopic partial liver resection. Histopathologic examination confirmed that the liver metastasis was consistent with CCSLTGT. It has now been 3 years without a recurrence. Conclusion Repeated radical surgical resection with close follow-up may be the only way to achieve long-term survival in patients with CCLSTGT.

Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system

2000 ◽  
Vol 11 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Akira Nakayama ◽  
Hiroshi Saitoh ◽  
Masako Oda ◽  
Masahiko Takada ◽  
Bruce J Aungst
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Efflux System ◽  
P Glycoprotein

Decrease in oral bioavailability of cyclosporin A by coadministration of probucol in rats

Life Sciences ◽  
1996 ◽  
Vol 60 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Koh-ichi Sugimoto ◽  
Koh-ichi Sakamoto ◽  
Akio Fujimura
Keyword(s):  
Cyclosporin A ◽  
Oral Bioavailability

THE EFFECT OF LONG-TERM CYCLOSPORIN A ON RENAL FUNCTION

The Lancet ◽  
1981 ◽  
Vol 317 (8231) ◽  
pp. 1218-1219 ◽  
Author(s):  
D.V. Hamilton ◽  
R.Y. Calne ◽  
D.B. Evans ◽  
R.G. Henderson ◽  
S. Thiru ◽  
...  
Keyword(s):  
Renal Function ◽  
Cyclosporin A

scholarly journals Long-Term Cardiovascular Effects of Levothyroxine Therapy in Young Adults with Congenital Hypothyroidism

2008 ◽  
Vol 93 (7) ◽  
pp. 2486-2491 ◽  
Author(s):  
Mariacarolina Salerno ◽  
Ugo Oliviero ◽  
Teresa Lettiero ◽  
Vincenzo Guardasole ◽  
Dario Maria Mattiacci ◽  
...  
Keyword(s):  
Young Adults ◽  
Replacement Therapy ◽  
Exercise Capacity ◽  
Congenital Hypothyroidism ◽  
Intima Media Thickness ◽  
Normal Range ◽  
Levothyroxine Replacement ◽  
Levothyroxine Treatment ◽  
Tsh Levels

Abstract Context: Congenital hypothyroidism (CH) is the most prevalent endocrine disorder in the newborn and is routinely treated with life-long levothyroxine replacement therapy. Although several studies have demonstrated that such therapy may impact on the cardiovascular system, little is known with regard to the effects of long-term levothyroxine administration in patients with CH. Objective: The aim of the current study was to evaluate whether long-term levothyroxine replacement therapy in young adults with CH is associated with cardiovascular abnormalities. Patients and Methods: Thirty young adults with CH aged 18.1 ± 0.2 yr and 30 age- and sex-matched controls underwent cardiac and carotid Doppler ultrasound and symptom-limited cardiopulmonary exercise testing. Hypothyroidism was diagnosed by neonatal screening, and levothyroxine treatment was initiated within the first month of life and carefully adjusted to maintain TSH levels in the normal range and free T4 in the high-normal range. Results: Compared with controls, hypothyroid patients exhibited left ventricular diastolic dysfunction, impaired exercise capacity, and increased intima-media thickness. At multiple regression analysis, the number of episodes of plasma TSH levels less than 0.5 mU/liter and greater than 4.0 mU/liter from the age of 1 yr onward, and mean TSH plasma levels during puberty were independent predictors of diastolic filling and cardiopulmonary performance indexes (multiple r values: 0.61–0.75). Conclusions: Long-term levothyroxine treatment in young adults with congenital hypothyroidism is associated with impaired diastolic function and exercise capacity and increased intima-media thickness.

Effect of a P-glycoprotein inhibitor, cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(––)-RWAY

Synapse ◽  
2006 ◽  
Vol 61 (2) ◽  
pp. 96-105 ◽  
Author(s):  
Jeih-San Liow ◽  
Shuiyu Lu ◽  
Julie A. McCarron ◽  
Jinsoo Hong ◽  
John L. Musachio ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Rodent Brain ◽  
P Glycoprotein
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