Functional Characteristics and Pharmacokinetic Significance of Kidney-specific Organic Anion Transporters, OAT-K1 and OAT-K2, in the Urinary Excretion of Anionic Drugs

2003 ◽  
Vol 18 (2) ◽  
pp. 91-103 ◽  
Author(s):  
Satohiro Masuda
Keyword(s):  
Urinary Excretion ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Functional Characteristics ◽  
Anion Transporters ◽  
Anionic Drugs

scholarly journals ROLE OF RENAL ORGANIC ANION TRANSPORTERS, OAT-K1 AND OAT-K2, IN THE URINARY EXCRETION OF ANIONIC DRUGS

2000 ◽  
Vol 15 (supplement) ◽  
pp. 96-97
Author(s):  
Ayako Takeuchi ◽  
Satohiro Masuda ◽  
Hideyuki Saito ◽  
Ken-ichi Inui
Keyword(s):  
Urinary Excretion ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Anionic Drugs

scholarly journals Role of Renal Organic Anion Transporters, OAT-K1 aud OAT-K2, in the Urinary Excretion of Anionic Drugs.

2001 ◽  
Vol 16 (2) ◽  
pp. 134-139
Author(s):  
Ayako TAKEUCHI ◽  
Satohiro MASUDA ◽  
Hideyuki SAITO ◽  
Ken-ichi INUI
Keyword(s):  
Urinary Excretion ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Anionic Drugs

Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein

2012 ◽  
Vol 302 (12) ◽  
pp. F1640-F1649 ◽  
Author(s):  
Maki Nomura ◽  
Hideyuki Motohashi ◽  
Hiroko Sekine ◽  
Toshiya Katsura ◽  
Ken-ichi Inui
Keyword(s):  
Protein Expression ◽  
Organic Anion ◽  
Immunohistochemical Analysis ◽  
Tubular Secretion ◽  
Organic Anion Transporters ◽  
Adult Rats ◽  
Anion Transporters ◽  
Anionic Drugs ◽  
Clearance Study

Organic anion transporters (OAT1 and OAT3) and multidrug resistance-associated proteins (MRP2 and MRP4) play important roles in anionic drug secretion in renal proximal tubules. Changes in the expression of such transporters are considered to affect the tubular secretion of anionic drugs. The purpose of this study was to elucidate the developmental changes in the expression of OAT1, OAT3, MRP2, and MRP4 and their effects on the tubular secretion of drugs. The mRNA level of each transporter was measured by real-time PCR, and the protein expression was evaluated by Western blotting and immunohistochemical analysis. In addition, the tubular secretion of phenolsulfonphthalein (PSP) in infant (postnatal day 14) and adult rats was estimated based on in vivo clearance study. The protein expression of organic anion transporters were very low at postnatal day 0 and gradually increased with age. In postnatal day 14 rats, the expression of OAT1 and OAT3 seemed to be at almost mature levels, while MRP2 and MRP4 seemed to be at immature levels. Immunohistochemical analysis in the kidney of postnatal day 0 rats revealed OATs on the basolateral membrane and MRPs on the brush-border membrane. At postnatal day 0, the distribution of these transporters was restricted to the inner cortical region, while after postnatal day 14, it was identical to that in adult kidney. An in vivo clearance study revealed that the tubular secretion of PSP was significantly lower in postnatal day 14 rats than adult rats. These results indicate that age-dependent changes in organic anion transporter expression affect the tubular secretion of anionic drugs in pediatric patients.

scholarly journals Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate

2001 ◽  
Vol 60 (3) ◽  
pp. 1058-1068 ◽  
Author(s):  
Ayako Takeuchi ◽  
Satohiro Masuda ◽  
Hideyuki Saito ◽  
Toshio Doi ◽  
Ken-Ichi Inui
Keyword(s):  
Urinary Excretion ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters

Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)

2016 ◽  
Vol 468 (11-12) ◽  
pp. 1909-1918 ◽  
Author(s):  
Birgitta C. Burckhardt ◽  
Maja Henjakovic ◽  
Yohannes Hagos ◽  
Gerhard Burckhardt
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporters ◽  
Counter Flow ◽  
Anion Transporters

scholarly journals Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors

2015 ◽  
Vol 43 (12) ◽  
pp. 1855-1863 ◽  
Author(s):  
Wei Wu ◽  
Kevin T. Bush ◽  
Henry C. Liu ◽  
Christopher Zhu ◽  
Ruben Abagyan ◽  
...  
Keyword(s):  
Organic Anion ◽  
Odorant Receptors ◽  
Organic Anion Transporters ◽  
Anion Transporters

scholarly journals (−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters

ACS Omega ◽  
2021 ◽  
Vol 6 (6) ◽  
pp. 4347-4354
Author(s):  
Tatsuya Kawasaki ◽  
Masaki Kondo ◽  
Rioka Hiramatsu ◽  
Tomohiro Nabekura
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters
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