Twenty­six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR1I3(CAR) Gene in a Japanese Population

2003 ◽  
Vol 18 (6) ◽  
pp. 413-418 ◽  
Author(s):  
Shinobu Ikeda ◽  
Kouichi Kurose ◽  
Shogo Ozawa ◽  
Kimie Sai ◽  
Ryuichi Hasegawa ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Japanese Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population

2016 ◽  
Vol 29 (5) ◽  
pp. 299-308 ◽  
Author(s):  
Midori Ninomiya-Baba ◽  
Junko Matsuo ◽  
Daimei Sasayama ◽  
Hiroaki Hori ◽  
Toshiya Teraishi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Single Nucleotide Polymorphisms ◽  
Japanese Population ◽  
Memory Performance ◽  
Psychiatric Disease ◽  
Psychiatric Diseases ◽  
Healthy Controls ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Poor Memory

ObjectiveObesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population.MethodsThe subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls. Memory performance was assessed using the Wechsler Memory Scale – Revised (WMS-R). Genomic DNA was prepared from venous blood and used to genotype 23 BMI-related SNPs using the TaqMan 5′-exonuclease allelic discrimination assay. We then analysed the relationships between the SNPs and psychiatric disease and various subscales of the WMS-R.ResultsThree SNPs (rs11142387, rs12597579, and rs6548238) showed significant differences in the genotype or allele frequency between patients with any psychiatric diseases and controls. Furthermore, six SNPs (rs11142387, rs12597579, rs2815752, rs2074356, rs4776970, and rs2287019) showed significant differences in at least one subscale of the WMS-R depending on the genotypes of the healthy controls. Interestingly, rs11142387 near the Kruppel-like factor 9 (KLF9) was significantly associated with psychiatric disease and poor memory function.ConclusionsWe identified three and six BMI-related SNPs associated with psychiatric disease and memory performance, respectively. In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.

Genotyping of five single nucleotide polymorphisms in theOCA2andHERC2genes associated with blue-brown eye color in the Japanese population

2009 ◽  
Vol 27 (5) ◽  
pp. 323-327 ◽  
Author(s):  
Reiko Iida ◽  
Misuzu Ueki ◽  
Haruo Takeshita ◽  
Junko Fujihara ◽  
Tamiko Nakajima ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Japanese Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Eye Color

scholarly journals Two novel single-nucleotide polymorphisms of the Caspase-9 (CASP9) gene in the Japanese population

2001 ◽  
Vol 2 (2) ◽  
pp. 117-118 ◽  
Author(s):  
A Hirano ◽  
H Nagai ◽  
H Harada ◽  
S Haga ◽  
T Kajiwara ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Japanese Population ◽  
Nucleotide Polymorphisms ◽  
Caspase 9 ◽  
Single Nucleotide

A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population

The Prostate ◽  
2010 ◽  
Vol 71 (10) ◽  
pp. 1023-1032 ◽  
Author(s):  
Miao Liu ◽  
Motofumi Suzuki ◽  
Tomio Arai ◽  
Motoji Sawabe ◽  
Yutaka Enomoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Japanese Population ◽  
Replication Study ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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