Metabolism of N,N-Dipropyl-2-[4-Methoxy-3-(2-Phenyl-Ethoxy)-Phenyl]-Ethyl-Amine-Monohydrochloride (NE-100), A Novel Sigma Ligand: Contribution of Cytochrome P450 Forms Involved in the Formation of Individual Metabolites in Human Liver and Small Intestine

Takahito Yamamoto; Naoko Hagima; Misako Fukasawa; Jun-ichi Yamaguchi; Masato Nakamura; Yoshiro Kohno; Kiyoshi Nagata; Yasushi Yamazoe

doi:10.2133/dmpk.18.173

Metabolism of N,N-Dipropyl-2-[4-Methoxy-3-(2-Phenyl-Ethoxy)-Phenyl]-Ethyl-Amine-Monohydrochloride (NE-100), A Novel Sigma Ligand: Contribution of Cytochrome P450 Forms Involved in the Formation of Individual Metabolites in Human Liver and Small Intestine

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.18.173 ◽

2003 ◽

Vol 18 (3) ◽

pp. 173-185 ◽

Cited By ~ 2

Author(s):

Takahito Yamamoto ◽

Naoko Hagima ◽

Misako Fukasawa ◽

Jun-ichi Yamaguchi ◽

Masato Nakamura ◽

...

Keyword(s):

Cytochrome P450 ◽

Small Intestine ◽

Human Liver ◽

Sigma Ligand ◽

Ethyl Amine

Download Full-text

Differences in Cytochrome P450 Forms Involved in the Metabolism ofN,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a Novel Sigma Ligand, in Human Liver and Intestine

Drug Metabolism and Disposition ◽

10.1124/dmd.31.1.60 ◽

2003 ◽

Vol 31 (1) ◽

pp. 60-66 ◽

Cited By ~ 4

Author(s):

Takahito Yamamoto ◽

Naoko Hagima ◽

Masato Nakamura ◽

Yoshiro Kohno ◽

Kiyoshi Nagata ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Sigma Ligand

Download Full-text

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽

10.1080/00498250903171395 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090901052053001-8

Author(s):

K. Murai ◽

H. Yamazaki ◽

K. Nakagawa ◽

R. Kawai ◽

T. Kamataki

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Cancer Drug ◽

Anti Cancer ◽

Cytochrome P450 2A6

Download Full-text

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

Pharmacology & Toxicology ◽

10.1034/j.1600-0773.2000.d01-38.x ◽

2000 ◽

Vol 86 (5) ◽

pp. 215-221 ◽

Cited By ~ 36

Author(s):

Paivi Taavitsainen ◽

Markku Anttila ◽

Leena Nyman ◽

Hari Karnani ◽

Jarmo S. Salonen ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Vitro Study

Download Full-text

Faculty Opinions recommendation of Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725255659.793503845 ◽

2015 ◽

Author(s):

Joyce Goldstein

Keyword(s):

Cytochrome P450 ◽

Molecular Recognition ◽

Ubiquitin Ligase ◽

Human Liver ◽

E3 Ubiquitin Ligase ◽

Cytochrome P450 3A4 ◽

Autocrine Motility Factor ◽

Motility Factor ◽

Liver Cytochrome

Download Full-text

Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes

Xenobiotica ◽

10.1080/00498254.2021.1950866 ◽

2021 ◽

pp. 1-47

Author(s):

Haruna Nagayoshi ◽

Norie Murayama ◽

Shigeo Takenaka ◽

Vitchan Kim ◽

Donghak Kim ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Cytochrome P450 2A6

Download Full-text

Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P450 2B6- and 2C8-Dependent Activity in Human Liver Microsomes

Drug Metabolism and Disposition ◽

10.1124/dmd.107.016816 ◽

2007 ◽

Vol 35 (11) ◽

pp. 1990-1995 ◽

Cited By ~ 21

Author(s):

Ragini Vuppugalla ◽

Shu-Ying Chang ◽

Hongjian Zhang ◽

Punit H. Marathe ◽

David A. Rodrigues

Keyword(s):

Cytochrome P450 ◽

Organic Solvents ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Cytochrome P450 2B6 ◽

Dependent Activity ◽

Kinetics Of

Download Full-text

Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes

Xenobiotica ◽

10.1080/00498250110065595 ◽

2001 ◽

Vol 31 (10) ◽

pp. 713-723 ◽

Cited By ~ 31

Author(s):

M. Miyazawa ◽

M. Shindo ◽

T. Shimada

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Cyclic Ether ◽

Human Liver Microsomes ◽

Cytochrome P450 3A

Download Full-text

Phosphonate O-Deethylation of [4-(4-Bromo-2-Cyano-Phenylcarbamoyl) Benzyl]-Phosphonic Acid Diethyl Ester, a Lipoprotein Lipase-Promoting Agent, Catalyzed by Cytochrome P450 2C8 and 3A4 in Human Liver Microsomes

Drug Metabolism and Disposition ◽

10.1124/dmd.30.3.301 ◽

2002 ◽

Vol 30 (3) ◽

pp. 301-306 ◽

Cited By ~ 7

Author(s):

Yujiro Morioka ◽

Makiko Otsu ◽

Shinsaku Naito ◽

Teruko Imai

Keyword(s):

Cytochrome P450 ◽

Lipoprotein Lipase ◽

Phosphonic Acid ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Diethyl Ester ◽

Cytochrome P450 2C8

Download Full-text

Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes

Drug Metabolism and Disposition ◽

10.1124/dmd.111.043679 ◽

2011 ◽

Vol 40 (3) ◽

pp. 596-601 ◽

Cited By ~ 23

Author(s):

Leah A. Gates ◽

Ding Lu ◽

Lisa A. Peterson

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Cytochrome P450 Enzymes

Download Full-text

Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker

Xenobiotica ◽

10.1080/004982597240064 ◽

1997 ◽

Vol 27 (9) ◽

pp. 885-900 ◽

Cited By ~ 9

Author(s):

T. TERAMURA* ◽

Y. FUKUNAGA ◽

E. J. VAN HOOGDALEM ◽

T. WATANABE ◽

S. HIGUCHI

Keyword(s):

Cytochrome P450 ◽

Calcium Channel ◽

Calcium Channel Blocker ◽

Metabolic Pathways ◽

Human Liver ◽

Channel Blocker ◽

Liver Cytochrome ◽

P450 Isozymes ◽

Cytochrome P450 Isozymes

Download Full-text