Metabolic Fate of Pitavastatin, a New Inhibitor of HMG-CoA Reductase—Effect of cMOAT Deficiency on Hepatobiliary Excretion in Rats and of mdr 1a/b Gene Disruption on Tissue Distribution in Mice

Hideki Fujino; Iwao Yamada; Syunsuke Shimada; Junji Kojima

doi:10.2133/dmpk.17.449

Metabolic Fate of Pitavastatin, a New Inhibitor of HMG-CoA Reductase—Effect of cMOAT Deficiency on Hepatobiliary Excretion in Rats and of mdr 1a/b Gene Disruption on Tissue Distribution in Mice

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.17.449 ◽

2002 ◽

Vol 17 (5) ◽

pp. 449-456 ◽

Cited By ~ 21

Author(s):

Hideki Fujino ◽

Iwao Yamada ◽

Syunsuke Shimada ◽

Junji Kojima

Keyword(s):

Tissue Distribution ◽

Gene Disruption ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Metabolic fate of simvastatin, an inhibitor of HMG-CoA reductase. (1): Absorption, distribution, metabolism and excretion of (14C) simvastatin after single administration in male rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.5.133 ◽

1990 ◽

Vol 5 (2) ◽

pp. 133-149 ◽

Cited By ~ 1

Author(s):

Naotaka UCHIYAMA ◽

Yuko SAITO ◽

Yayoi KAGAMI ◽

Ken-ichi HARA ◽

Kaoru SAITO ◽

...

Keyword(s):

Male Rats ◽

Single Administration ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (4). Interspecies Variation in Laboratory Animals and Humans.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.14.79 ◽

1999 ◽

Vol 14 (2) ◽

pp. 79-91 ◽

Cited By ~ 3

Author(s):

Hideki FUJINO ◽

Junji KOJIMA ◽

Youichi YAMADA ◽

Hiroyasu KANDA ◽

Hideki KIMATA

Keyword(s):

Laboratory Animals ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Interspecies Variation ◽

Coa Reductase

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Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (3). Foeto-placental Transfer and Mammary Excretion after Oral Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.508 ◽

1998 ◽

Vol 13 (5) ◽

pp. 508-515 ◽

Cited By ~ 1

Author(s):

Hideki FUJINO ◽

Shigeru MORIKAWA ◽

Hiroyasu KANDA ◽

Hideki KIMATA

Keyword(s):

Oral Administration ◽

Placental Transfer ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (2). Absorption, Distribution, Metabolism, Excretion and Accumulation Following Repeated Oral Administration of 14C-NK-104 in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.499 ◽

1998 ◽

Vol 13 (5) ◽

pp. 499-507 ◽

Cited By ~ 4

Author(s):

Hideki FUJINO ◽

Yoshihiko TSUNENARI ◽

Takashi KOIDE ◽

Masahiro YONEMITSU ◽

Yoshinobu YANAGAWA ◽

...

Keyword(s):

Oral Administration ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ◽

10.1016/0005-2760(92)90103-3 ◽

1992 ◽

Vol 1123 (2) ◽

pp. 133-144 ◽

Cited By ~ 67

Author(s):

Thomas M.A. Bocan ◽

Erika Ferguson ◽

William McNally ◽

Paul D. Uhlendorf ◽

Sandra Bak Mueller ◽

...

Keyword(s):

Tissue Distribution ◽

Reductase Inhibitor ◽

Sterol Synthesis ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitor ◽

Coa Reductase

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Metabolic fate of simvastatin, an inhibitor of HMG-CoA reductase. (2): Absorption, distribution and excretion after consecutive oral administration, and foeto-placental transfer and excretion into milk of (14C) simvastatin in rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.5.151 ◽

1990 ◽

Vol 5 (2) ◽

pp. 151-163 ◽

Cited By ~ 1

Author(s):

Masakatsu OHTAWA ◽

Naotaka UCHIYAMA ◽

Kaoru SAITO ◽

Yoshio ESUMI ◽

Yoshitaka JIN

Keyword(s):

Oral Administration ◽

Placental Transfer ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Studies on the metabolic fate of itavastatin, a new inhibitor of HMG-CoA reductase-in vitro metabolism

Atherosclerosis ◽

10.1016/s0021-9150(00)80226-9 ◽

2000 ◽

Vol 151 (1) ◽

pp. 50 ◽

Cited By ~ 2

Author(s):

H Fujino ◽

I Yamada ◽

S Shimada ◽

H Matsumoto ◽

M Yoneda

Keyword(s):

In Vitro Metabolism ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization

Xenobiotica ◽

10.1080/0049825021000017957 ◽

2003 ◽

Vol 33 (1) ◽

pp. 27-41 ◽

Cited By ~ 68

Author(s):

H. Fujino ◽

I. Yamada ◽

S. Shimada ◽

M. Yoneda ◽

J. Kojima

Keyword(s):

Metabolic Fate ◽

Hmg Coa Reductase ◽

Udp Glucuronosyltransferase ◽

Coa Reductase

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Metabolic Fate of Fluvastatin, an Inhibitor of HMG-CoA Reductase. (2): Transfer to the Fetus and Milk, and Absorption, Distribution and Excretion after Consecutive Oral Administration of (14C)Fluvastatin in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.529 ◽

1995 ◽

Vol 10 (4) ◽

pp. 529-546 ◽

Cited By ~ 1

Author(s):

Naoki MASUDA ◽

Izumi AKASAKA ◽

Masakatsu OHTAWA

Keyword(s):

Oral Administration ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Metabolic Fate of Fluvastatin, an Inhibitor of HMG-CoA Reductase. (1): Absorption, Distribution and Excretion of (14C)Fluvastatin after Single Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.513 ◽

1995 ◽

Vol 10 (4) ◽

pp. 513-528 ◽

Cited By ~ 4

Author(s):

Naoki MASUDA ◽

Izumi AKASAKA ◽

Masakatsu OHTAWA

Keyword(s):

Single Administration ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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