scholarly journals Chronic toxicity study of AC-1370 sodium, an antibiotics, intravenously administered in rats.

1984 ◽  
Vol 9 (4) ◽  
pp. 363-388 ◽  
Author(s):  
Masaya TAKEUCHI ◽  
Mieko IWATA ◽  
Masao KIGUCHI ◽  
Masayo KAGA ◽  
Kotaro SHIMPO ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Toxicity Study

scholarly journals SUB-CHRONIC TOXICITY STUDY OF THE RAMBUTAN RIND EXTRACT IN MALE WISTAR RATS

2012 ◽  
Vol 10 (2) ◽  
pp. 101-1
Author(s):  
Aree Thinkratok ◽  
Parin Suwannaprapha ◽  
Rungrudee Srisawat
Keyword(s):  
Wistar Rats ◽  
Chronic Toxicity ◽  
Toxicity Study ◽  
Male Wistar Rats

Mesovarial Leiomyomas in Rats in a Chronic Toxicity Study of Soterenol Hydrochloride

1971 ◽  
Vol 8 (5-6) ◽  
pp. 452-457 ◽  
Author(s):  
L. W. Nelson ◽  
W. A. Kelly
Keyword(s):  
Smooth Muscle ◽  
Adrenergic Receptors ◽  
Dose Group ◽  
Chronic Toxicity ◽  
Low Dose ◽  
Toxicity Study ◽  
Ovarian Cysts ◽  
High Dose ◽  
Oral Toxicity ◽  
Β Adrenergic Receptors

In an 18-month oral toxicity study of soterenol hydrochloride, a stimulant of the β-adrenergic receptors, mesovarial leiomyomas were observed in three of 30 low-dose, six of 30 middle-dose and 10 of 30 high-dose rats. There was also an increase in the prevalence of ovarian cysts and of focal hyperplasia of smooth muscle in the mesovaria in the treated rats, especially in the high-dose group.

scholarly journals Protective effects of resveratrol on biomarkers of oxidative stress, biochemical and histopathological changes induced by sub-chronic oral glyphosate-based herbicide in rats

2019 ◽  
Vol 8 (2) ◽  
pp. 238-245 ◽  
Author(s):  
Ruhi Turkmen ◽  
Yavuz Osman Birdane ◽  
Hasan Huseyin Demirel ◽  
Mustafa Kabu ◽  
Sinan Ince
Keyword(s):  
Oxidative Stress ◽  
Chronic Toxicity ◽  
Toxicity Study ◽  
Protective Effects ◽  
Histopathological Changes ◽  
Blood Brain ◽  
Biomarkers Of Oxidative Stress

The aim of this sub-chronic toxicity study is to determine the protective effects of Resveratrol (Res) on oxidative stress, biochemical and histopathological changes induced by glyphosate-based herbicide (GBH) in the blood, brain, heart, liver and renal tissues.

Toxicological assessment of combined lead and cadmium: Acute and sub-chronic toxicity study in rats

2014 ◽  
Vol 65 ◽  
pp. 260-268 ◽  
Author(s):  
Guiping Yuan ◽  
Shujun Dai ◽  
Zhongqiong Yin ◽  
Hongke Lu ◽  
Renyong Jia ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Toxicity Study ◽  
Toxicological Assessment ◽  
Lead And Cadmium

scholarly journals CHRONIC TOXICITY STUDY OF RANITIDINE HYDROCHLORIDE ORALLY ADMINISTERED IN RATS

1983 ◽  
Vol 8 (SupplementI) ◽  
pp. 25-49 ◽  
Author(s):  
Masaya TAKEUCHI ◽  
Masayo KAGA ◽  
Masao KIGUCHI ◽  
Mieko IWATA ◽  
Mizue YAMAGUCHI ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Toxicity Study ◽  
Ranitidine Hydrochloride

Aliphatic hydrocarbons in sediments: a chronic toxicity study with winter flounder (Pleuronectes americanus) exposed to oil well drill cuttings

1995 ◽  
Vol 52 (12) ◽  
pp. 2724-2735 ◽  
Author(s):  
J. F. Payne ◽  
L. L Fancey ◽  
J. Hellou ◽  
M. J. King ◽  
G. L. Fletcher
Keyword(s):  
Marine Environment ◽  
Dose Response ◽  
Chronic Toxicity ◽  
Winter Flounder ◽  
Toxicity Study ◽  
Detoxification Enzymes ◽  
Drilling Fluids ◽  
Exposure Level ◽  
Pleuronectes Americanus ◽  
Drill Cuttings

Most studies on the chronic toxicity of hydrocarbons have focused on the polycyclic aromatic component; however, information is also required on the chronic toxicity of other classes of hydrocarbons. This need has been brought to the forefront by the controversy about the use of aliphatic hydrocarbon-based drilling fluids at petroleum development sites in the marine environment. Dose–response relationships were studied for a variety of indices in a chronic toxicity study with winter flounder (Pleuronectes americanus) exposed to sediments contaminated with drill cuttings enriched in hydrocarbons. The indices investigated were biologically meaningful and included organ and body condition indices, muscle and liver energy reserves, mixed-function oxygenase detoxification enzymes, blood parameters, and liver and gill histopathology. There was no evidence of dose–response relationships and most indices remained unaffected even at the highest exposure level. The study supports the hypothesis that the aliphatic component of complex hydrocarbon mixtures is relatively nontoxic, and it will be of particular interest for evaluating the scope of environmental risks associated with the use of oil-base drilling fluids in the marine environment.

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