Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid

Yusuke Kamiya; Mayu Yanagi; Shiori Hina; Kazuki Shigeta; Tomonori Miura; Hiroshi Yamazaki

doi:10.2131/jts.45.763

Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid

The Journal of Toxicological Sciences ◽

10.2131/jts.45.763 ◽

2020 ◽

Vol 45 (12) ◽

pp. 763-767

Author(s):

Yusuke Kamiya ◽

Mayu Yanagi ◽

Shiori Hina ◽

Kazuki Shigeta ◽

Tomonori Miura ◽

...

Keyword(s):

Sulfonic Acid ◽

Pharmacokinetic Models ◽

Industrial Chemicals ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Liver And Kidney ◽

Oral Doses

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Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.0c00009 ◽

2020 ◽

Vol 33 (7) ◽

pp. 1736-1751 ◽

Cited By ~ 5

Author(s):

Yusuke Kamiya ◽

Shohei Otsuka ◽

Tomonori Miura ◽

Manae Yoshizawa ◽

Ayane Nakano ◽

...

Keyword(s):

Pharmacokinetic Models ◽

Industrial Chemicals ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Oral Doses

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In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.0c00336 ◽

2021 ◽

Vol 34 (2) ◽

pp. 507-513 ◽

Cited By ~ 1

Author(s):

Yusuke Kamiya ◽

Kentaro Handa ◽

Tomonori Miura ◽

Mayu Yanagi ◽

Kazuki Shigeta ◽

...

Keyword(s):

In Silico ◽

Pharmacokinetic Models ◽

In Silico Prediction ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Input Parameters ◽

Liver And Kidney ◽

Oral Doses

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Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Cited By ~ 7

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

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An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.1c00249 ◽

2021 ◽

Author(s):

Yusuke Kamiya ◽

Kentaro Handa ◽

Tomonori Miura ◽

Junya Ohori ◽

Makiko Shimizu ◽

...

Keyword(s):

In Silico ◽

Prediction Method ◽

Systemic Circulation ◽

Pharmacokinetic Models ◽

In Silico Prediction ◽

Tissue Concentrations ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Oral Doses

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Development and Qualification of Physiologically Based Pharmacokinetic Models for Drugs With Atypical Distribution Behavior: A Desipramine Case Study

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12180 ◽

2017 ◽

Vol 6 (5) ◽

pp. 315-321 ◽

Cited By ~ 11

Author(s):

TS Samant ◽

V Lukacova ◽

S Schmidt

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Distribution Behavior

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2013.03.005 ◽

2013 ◽

Vol 66 (1) ◽

pp. 116-129 ◽

Cited By ~ 18

Author(s):

M.E. (Bette) Meek ◽

Hugh A. Barton ◽

Jos G. Bessems ◽

John C. Lipscomb ◽

Kannan Krishnan

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Reducing Whole Body Physiologically Based Pharmacokinetic Models Using Global Sensitivity Analysis: Diazepam Case Study

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-005-0004-8 ◽

2005 ◽

Vol 33 (1) ◽

pp. 1-27 ◽

Cited By ~ 33

Author(s):

Ivelina Gueorguieva ◽

Ivan A. Nestorov ◽

Malcolm Rowland

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Whole Body ◽

Pharmacokinetic Models ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Cited By ~ 5

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-16 ◽

2006 ◽

pp. 301-348 ◽

Cited By ~ 2

Author(s):

Robert De Woskin ◽

Chadwick Thompson ◽

Weihsueh Chiu ◽

Paul Schlosser ◽

Carolyn Smallwood ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Integrated Risk ◽

Physiologically Based

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