scholarly journals The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats

2019 ◽  
Vol 44 (7) ◽  
pp. 459-469 ◽  
Author(s):  
Takafumi Yamaguchi ◽  
Minoru Maeda ◽  
Keiko Ogata ◽  
Jun Abe ◽  
Toru Utsumi ◽  
...  
Keyword(s):  
Endocrine System ◽  
Male Rats ◽  
Juvenile Male ◽  
Ethylhexyl Phthalate ◽  
Induction By Phenobarbital

scholarly journals Juvenile male rats display lower cortical metabolic capacity than females

2008 ◽  
Vol 440 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Jaclyn M. Spivey ◽  
Rene A. Colorado ◽  
Nelida Conejo-Jimenez ◽  
Hector Gonzalez-Pardo ◽  
F. Gonzalez-Lima
Keyword(s):  
Male Rats ◽  
Juvenile Male ◽  
Metabolic Capacity

Sexual behaviour of juvenile male rats injected with lisuride

1984 ◽  
Vol 9 (2-3) ◽  
pp. 281-291
Author(s):  
Z. Hliñák ◽  
I. Dvorská
Keyword(s):  
Sexual Behaviour ◽  
Male Rats ◽  
Juvenile Male

scholarly journals Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162027 ◽  
Author(s):  
Niels Hadrup ◽  
Terje Svingen ◽  
Karen Mandrup ◽  
Kasper Skov ◽  
Mikael Pedersen ◽  
...  
Keyword(s):  
Health Effects ◽  
Low Dose ◽  
Environmental Chemicals ◽  
Male Rats ◽  
Juvenile Male ◽  
Adverse Health Effects ◽  
Adverse Health

scholarly journals The Effects of Mono-(2-Ethylhexyl) Phthalate (MEHP) on Human Estrogen Receptor (hER) and Androgen Receptor (hAR) by YES/YAS In Vitro Assay

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1558 ◽  
Author(s):  
Kim ◽  
Park ◽  
Kim ◽  
Kim
Keyword(s):  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Endocrine System ◽  
Yeast Cells ◽  
Signal Recovery ◽  
Vitro Assay ◽  
Recovery Test ◽  
Human Estrogen Receptor ◽  
Ethylhexyl Phthalate

Endocrine active compounds with structural similarities to natural hormones such as 17β-estradiol (E2) and androgen are suspected to affect the human endocrine system by inducing hormone-dependent effects. This study aimed to detect the (anti-)estrogenic and (anti-)androgenic activities of mono-(2-ethylhexyl) phthalate (MEHP) by yeast estrogen/androgen bioassay (YES/YAS). In addition, the mechanism and uptake of MEHP to receptors during agonistic and antagonistic activities were investigated through the activation signal recovery test and chromatographic analysis using liquid chromatography and tandem mass spectrometry (LC-MS/MS). Estrogenic and androgenic activities of MEHP were not observed. However, MEHP exhibited anti-estrogenic (IC50 = 125 μM) and anti-androgenic effects (IC50 = 736 μM). It was confirmed that these inhibitory effects of MEHP were caused by receptor-mediated activity of the estrogen receptor and non-receptor-mediated activity of the androgen receptor in an activation signal recovery test. When IC50 concentrations of anti-estrogenic and androgenic activity of MEHP were exposed to yeast cells, the uptake concentration observed was 0.0562 ± 0.0252 μM and 0.143 ± 0.0486 μM by LC-MS/MS analysis.

Influence of a Testosterone Antagonist (Cyproterone) on Pituitary and Serum FSH-Content in Juvenile Male Rats

1967 ◽  
Vol 2 (2) ◽  
pp. 107-112 ◽  
Author(s):  
R. von Berswordt-Wallrabe ◽  
F. Neumann
Keyword(s):  
Male Rats ◽  
Juvenile Male

197 DIFFERENTIAL EFFECTS OF FLUTAMIDE AND DI-(2-ETHYLHEXYL) PHTHALATE ON MALE REPRODUCTIVE ORGANS IN A RAT MODEL

2009 ◽  
Vol 21 (1) ◽  
pp. 197
Author(s):  
T. T. B. Vo ◽  
E.-M. Jung ◽  
M.-G. Back ◽  
V. H. Dang ◽  
K.-C. Choi ◽  
...  
Keyword(s):  
Sex Determination ◽  
Microarray Analysis ◽  
Expression Patterns ◽  
Reproductive Organs ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
High Dose ◽  
Total N ◽  
Male Reproductive Organs ◽  
Ethylhexyl Phthalate

Endocrine disruptors (EDs) with androgenic and anti-androgenic effects may alter reproductive function by binding to androgenic receptors (AR) and inducing or modulating AR-dependent responses in the male reproductive system. However, the molecular mechanism(s) underlying these events remains unclear. Thus, in the present study, we elucidated the prenatal effects of maternal testosterone propionate (TP), flutamide (Flu), and di-(2-ethylhexyl) phthalate (DEHP) on male reproductive organs of newborn rats. Pregnant Sprague-Dawley (n = 32 in total, n = 8/each group) rats were treated with these compounds at gestation days 11 to 21, and newborn males (n = 154 in total) were euthanized at post-neonatal day (PND) 63. Interestingly, maternal exposure to Flu or DEHP caused fluctuations in the neonatal levels of serum testosterone (T) and luteinizing hormone (LH). Serum T and LH were up-regulated by Flu, but these hormones were down-regulated by DEHP. The anogenital distances (AGD) of male newborns were detected at PND 1, 21, and 63. Male rats treated prenatally with DEHP (100 mg kg–1 mother’s body weight) or Flu showed an AGD shorter than that of control rats. At PND 63, the sperm concentration, viability, and mobility were reduced in the maternal DEHP and Flu-treated groups. The numbers of seminiferous tubules were reduced in the Flu- and DEHP-treated offspring when compared with vehicle- and TP-treated groups, and the tubules of the testes at PND 63 were disrupted by a high dose of Flu. In addition, we examined differential gene expression patterns in the testes by microarray analysis following ED exposure, particularly in sex determination-related genes. Significantly distinct expressions of sex determination-related genes were observed in the testes by microarray analysis following treatments with different types of EDs in this study. Although Flu and DEHP are considered to be identical with regard to their anti-androgenic effects, their effects on developing male reproductive organs were distinct, suggesting that Flu competes with endogenous T, while DEHP influences a different step in androgenesis.

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