scholarly journals Melatonin antagonizes oxidative stress-induced mitochondrial dysfunction in retinal pigmented epithelium cells via melatonin receptor 1 (MT1)

2018 ◽  
Vol 43 (11) ◽  
pp. 659-669 ◽  
Author(s):  
Guigang Yan ◽  
Lianzhi Yu ◽  
Songmei Jiang ◽  
Jianfeng Zhu
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Retinal Pigmented Epithelium ◽  
Melatonin Receptor ◽  
Pigmented Epithelium ◽  
Epithelium Cells

AGEs Promote Oxidative Stress and Induce Apoptosis in Retinal Pigmented Epithelium Cells RAGE-dependently

2015 ◽  
Vol 56 (2) ◽  
pp. 449-460 ◽  
Author(s):  
Xin-Ling Wang ◽  
Tao Yu ◽  
Qi-Chang Yan ◽  
Wei Wang ◽  
Nan Meng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinal Pigmented Epithelium ◽  
Pigmented Epithelium ◽  
Epithelium Cells

scholarly journals Eye Opener in Stroke

Stroke ◽  
2019 ◽  
Vol 50 (8) ◽  
pp. 2197-2206 ◽  
Author(s):  
Hung Nguyen ◽  
Jea Young Lee ◽  
Paul R. Sanberg ◽  
Eleonora Napoli ◽  
Cesar V. Borlongan
Keyword(s):  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Glucose Deprivation ◽  
Retinal Ischemia ◽  
Artery Occlusion ◽  
Oxygen Glucose Deprivation ◽  
Retinal Pigmented Epithelium ◽  
Pigmented Epithelium ◽  
Cerebral Artery Occlusion ◽  
Epithelium Cells

Background and Purpose— Retinal ischemia is a major cause of visual impairment in stroke patients, but our incomplete understanding of its pathology may contribute to a lack of effective treatment. Here, we investigated the role of mitochondrial dysfunction in retinal ischemia and probed the potential of mesenchymal stem cells (MSCs) in mitochondrial repair under such pathological condition. Methods— In vivo, rats were subjected to middle cerebral artery occlusion then randomly treated with intravenous MSCs or vehicle. Laser Doppler was used to evaluate the blood flow in the brain and the eye, while immunohistochemical staining assessed cellular degeneration at days 3 and 14 poststroke. In vitro, retinal pigmented epithelium cells were exposed to either oxygen-glucose deprivation or oxygen-glucose deprivation and coculture with MSCs, and subsequently, cell death and mitochondrial function were examined immunocytochemically and with Seahorse analyzer, respectively. Results— Middle cerebral artery occlusion significantly reduced blood flow in the brain and the eye accompanied by mitochondrial dysfunction and ganglion cell death at days 3 and 14 poststroke. Intravenous MSCs elicited mitochondrial repair and improved ganglion cell survival at day 14 poststroke. Oxygen-glucose deprivation similarly induced mitochondrial dysfunction and cell death in retinal pigmented epithelium cells; coculture with MSCs restored mitochondrial respiration, mitochondrial network morphology, and mitochondrial dynamics, which likely attenuated oxygen-glucose deprivation-mediated retinal pigmented epithelium cell death. Conclusions— Retinal ischemia is closely associated with mitochondrial dysfunction, which can be remedied by stem cell-mediated mitochondrial repair.

scholarly journals SirT1 and STAT3 protect retinal pigmented epithelium cells against oxidative stress

2015 ◽  
Vol 12 (2) ◽  
pp. 2231-2238 ◽  
Author(s):  
LANGEN LI ◽  
WEI WEI ◽  
YUFENG ZHANG ◽  
GERILE TU ◽  
YANMEI ZHANG ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinal Pigmented Epithelium ◽  
Pigmented Epithelium ◽  
Epithelium Cells

Effects of Hypoxia on Retinal Pigmented Epithelium Cells: Protection by Antioxidants

2002 ◽  
Vol 34 (6) ◽  
pp. 338-342 ◽  
Author(s):  
M. Castillo ◽  
J.L. Bellot ◽  
C. García-Cabanes ◽  
J. Miquel ◽  
A. Orts ◽  
...  
Keyword(s):  
Retinal Pigmented Epithelium ◽  
Pigmented Epithelium ◽  
Epithelium Cells

Postprandial dietary fatty acids exert divergent inflammatory responses in retinal-pigmented epithelium cells

2016 ◽  
Vol 7 (3) ◽  
pp. 1345-1353 ◽  
Author(s):  
Sergio Montserrat-de la Paz ◽  
M. Carmen Naranjo ◽  
Beatriz Bermudez ◽  
Sergio Lopez ◽  
Wenceslao Moreda ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Inflammatory Responses ◽  
Dietary Fatty Acids ◽  
Retinal Pigmented Epithelium ◽  
Complex Series ◽  
Postprandial Triglyceride ◽  
Pigmented Epithelium ◽  
Epithelium Cells

Postprandial triglyceride-rich lipoproteins (TRLs) lead to a complex series of events that are potentially oxidative and inflammatory.

scholarly journals Characterization of Retinal Pigmented Epithelium Cells Density on a MicroElectrode Array Using Impedance Spectroscopy

Proceedings ◽  
2017 ◽  
Vol 1 (4) ◽  
pp. 530
Author(s):  
Jocelyn Boutzen ◽  
Manon Valet ◽  
Valérie Fradot ◽  
Lionel Rousseau ◽  
Olivier Français ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Microelectrode Array ◽  
Retinal Pigmented Epithelium ◽  
Pigmented Epithelium ◽  
Epithelium Cells
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